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Number of reported cases* of acute Hepatitis B virus infection and estimated infections† — United States, 2014–2021
* Reported confirmed cases. For the case definition, see Acute Hepatitis B.
† The number of estimated viral hepatitis infections was determined by multiplying the number of reported cases that met the classification criteria for a confirmed case by a factor that adjusted for underascertainment and underreporting. The 95% bootstrap confidence intervals for the estimated number of infections are displayed in the Appendix.
The number of acute hepatitis B cases reported each year in the United States has remained relatively stable during 2014–2019 but decreased abruptly in 2020. During 2021, the number of reported cases of acute hepatitis B was 2,045, which corresponds to 13,300 estimated infections after adjusting for case underascertainment and underreporting.1 The number of reported cases in 2021 represents a 5% decrease from the number reported in 2020 (2,157 reported cases of acute hepatitis B).
The decreased cases observed in 2020 and 2021 could be due to prevention efforts but are also likely attributed to COVID-19 pandemic-related disruptions in healthcare access and reduction in the number of persons tested for hepatitis B virus infection. Furthermore, the ability of viral hepatitis surveillance staff to investigate and accurately determine acute case status was limited due to participation in the public health response to the COVID-19 pandemic.
- Figure 2.1. Number of reported cases of acute hepatitis B virus infection and estimated infections — United States, 2014–2021
- Figure 2.2. Rates of reported acute hepatitis B virus infection, by state or jurisdiction — United States, 2020–2021
- Figure 2.3. Rates of reported cases of acute hepatitis B virus infection, by state or jurisdiction — United States, 2021
- Figure 2.4. Rates of reported cases of acute hepatitis B virus infection, by age group — United States, 2006–2021
- Figure 2.5. Rates of reported cases of acute hepatitis B virus infection, by sex — United States, 2006–2021
- Figure 2.6. Rates of reported cases of acute hepatitis B virus infection, by race/ethnicity — United States, 2006–2021
- Figure 2.7. Availability of information on risk behaviors or exposures associated with reported cases of acute hepatitis B virus infection — United States, 2021
- Figure 2.8. Rates of deaths with hepatitis B virus infection listed as a cause of death among residents, by state or jurisdiction — United States, 2021
- Table 2.1. Numbers and rates of reported cases of acute hepatitis B virus infection, by state or jurisdiction — United States, 2017–2021
- Table 2.2. Numbers and rates of reported cases of acute hepatitis B virus infection, by demographic characteristics — United States, 2017–2021
- Table 2.3. Reported risk behaviors or exposures among reported cases of acute hepatitis B virus infection — United States, 2021
- Table 2.4. Number of newly reported cases of perinatal hepatitis B virus infection, by state or jurisdiction — United States, 2021
- Table 2.5. Number and rate of newly reported cases of chronic hepatitis B virus infection, by state or jurisdiction — United States, 2021
- Table 2.6. Number and rate of newly reported cases of chronic hepatitis B virus infection, by demographic characteristics — United States, 2021
- Table 2.7. Numbers and rates of deaths with hepatitis B virus infection listed as a cause of death among residents, by state or jurisdiction — United States, 2017–2021
- Table 2.8. Numbers and rates of deaths with hepatitis B virus infections listed as a cause of death among residents, by demographic characteristics — United States, 2017–2021
Source:
- Klevens RM, Liu S, Roberts H, et al. Estimating acute viral hepatitis infections from nationally reported cases. Am J Public Health 2014;104:482. PMC3953761.