Storage and Handling for Hib Vaccines

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Proper vaccine storage and handling practices play an important role in protecting individuals and communities from vaccine-preventable diseases. For general recommendations and guidance, see Vaccine Storage and Handling. Provided below is guidance specific to Haemophilus influenzae type b (Hib) vaccines.

Temperature

  • Store all Hib-containing vaccine refrigerated between 2°C and 8°C (36°F and 46°F).
  • Do not freeze vaccine or diluents, or expose to freezing temperatures. If the vaccine has been exposed to inappropriate conditions/temperatures or handled improperly:
    • Store the vaccine at the appropriate temperature
    • Isolate from other vaccines
    • Mark “Do NOT Use”
    • Consult the vaccine manufacturer and/or your state or local immunization program for guidance

Storage

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  • Store Hib vaccine in the original packaging.
    • For Hib vaccines that require reconstitution (Pentacel®, ActHIB®, Hiberix®), the manufacturer packages the diluent and vaccine together. They should be stored together in the refrigerator.

Reconstitution

  • For Hib vaccines that require reconstitution (Pentacel®, ActHIB®, Hiberix®), do NOT use if you cannot resuspend the reconstituted vaccine after thorough agitation.
    • Only reconstitute the ActHIB® in Pentacel® with the DTaP-IPV liquid provided by the manufacturer.
    • Only reconstitute the single-antigen ActHIB® with the 0.4% sodium chloride provided by the vaccine manufacturer.
    • Only reconstitute Hiberix® with the 0.9% sodium chloride provided by the vaccine manufacturer.
    • Never use stock vials of normal saline to reconstitute these vaccines.

Disposal

  • Discard vaccine vials and syringes using proper medical waste disposal procedures.

 

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