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Anatrichosomiasis

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[Anatrichosoma spp.] [Anatrichosoma buccalis] [Anatrichosoma cutaneum]

Causal Agents

Anatrichosoma is a genus of poorly understood tissue-dwelling nematodes that very rarely infect humans. They are generally associated with wild primate, rodent, and marsupial hosts, and share some morphologic similarities with other trichuroids such as Trichuris and Capillaria. Zoonotic infections have so far never been unequivocally identified to species level.

Life Cycle

Life Cycle
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The complete life cycle of Anatrichosoma spp. is unknown. The long, slender adults are found in tunnels in mucosal and squamous epithelial tissues of definitive hosts such as primates and marsupials image ; the particular anatomic site (e.g. skin, nasal/sinus cavity, mouth) is dependent on parasite species and males may be found in deeper layers of tissue than females. After copulation, the gravid females release embryonated eggs into the surrounding tissue, which are shed in mucosal secretions or eventually swallowed and shed in feces image . From that point, it is not known whether Anatrichosoma spp. follow an indirect cycle with intermediate host(s) image or a direct cycle without additional hosts image . Larval stages beyond what is present in eggs have not been identified, and experimental infections of potential intermediate hosts (e.g. beetles, cockroaches) have never succeeded.

The transmission route to humans is not known image . In one instance, two patients had skin exposure to snails but it is not known if snails play a role in the Anatrichosoma life cycle.

Hosts

Several Anatrichosoma spp. (A. cutaneum, A. cynomolgi, A. nacepobi, A. rhina) have been described from subcutaneous tissues of various Old World primates. Non-primate associated species include A. ocularis of common tree shrews (Tupaia glis), A. gerbilis of North African gerbils (Gerbillus campestris), A. haycocki of dasyurid marsupials, and A. buccalis of opossums (Didelphis virginiana). Aberrant infections may infrequently occur in humans, and occasionally occur in domestic dogs and cats.

Geographic Distribution

Anatrichosoma spp. have been found in a variety of locations in wildlife hosts but their broader occurrence is poorly understood. Zoonotic cases have been reported from Japan, Vietnam, Malaysia, Italy, and in a few patients from the United States with recent travel to Mexico.

Clinical Manifestations

In the few known human cases, clinical manifestations have involved the development of cutaneous or mucosal lesions caused by the presence of adult worms. Inflammatory tracks resembling cutaneous larva migrans/creeping eruption on the limbs, nodule formation, and ulceration of the oral mucosa have been described.

Anatrichosoma sp. adult

 

Anatrichosoma spp. are long and slender (both sexes up to ~30 mm long; females ~0.7 mm and males ~0.25 mm maximum width). Among nematodes, this group is unusual in that the male may be as long as the female, but is always more slender. Males also lack spicules and an ejaculatory duct. Eggs are barrel-shaped with two polar plugs and a coarsely striated shell, and are embryonated when passed.

Figure A
Figure A: Anatrichosoma sp. adult female from a naturally infected brown four-eyed opossum (Metachirus nudicaudatus), Ecuador. Note the very fine, attenuated posterior and gently tapering body.
Figure B
Figure B: Anterior region of the specimen shown in figure A. Numerous stichocytes (darts) are present, similar to related genera such as Trichuris and Capillaria.
Figure C
Figure C: View of the vaginal and uterine region of the specimen in figure A above. The vulva (arrow) is generally in the anterior portion of the body; mature eggs are seen in the anterior uterus (dart). Immature eggs are also visible in the more posterior region of the uterus (asterisk).
Anatrichosoma sp. in tissue

 

Most human cases of anatrichosomiasis have been identified via histological sections. In addition to the typical trichuroid stichosome, characteristic features include the minute size, paired bacillary bands, a single uterine tube, and embryonated eggs in utero and in surrounding tissue.

Figure A
Figure A: Cross sections of Anatrichosoma sp. (presumed A. buccalis) females in buccal tissue from an opossum, H&E stained. Sections through many anatomical levels are visible, including the gravid uterus with eggs.
Figure B
Figure B: Closer view of the female shown in Figure A. Note the single uterine tube (bottom, arrow) with developing eggs, and the minute intestinal tube (top, dart).
Figure C
Figure C: Cross-sections of a coiled Anatrichosoma sp. in the subcutaneous tissues of a Patas monkey (Erythrocebus patas).
Figure D
Figure D: Closer view of cross sections of male Anatrichosoma sp., showing the characteristic paired, dark-staining bacillary bands (arrows) which are visible in many sections (diameter ~70 µm).
Figure E
Figure E: Anatrichosoma sp. egg in tissue, showing the presence of polar plugs (arrows), a striated shell (dart), and coiled larva.
Figure E
Figure F: Anatrichosoma sp. egg in tissue. The higher focal plane shows the striated surface texture (arrow) of the shell (overall egg size ~70 µm long).

Laboratory Diagnosis

Diagnosis depends on the identification of adult Anatrichosoma spp. and eggs in tissue. Though this group possesses some distinct features visible in histological sections, it must be carefully distinguished from other nematodes that are morphologically similar (e.g. Trichuris, Capillaria) or that may appear in similar subcutaneous sites (e.g. Gongylonema, Dirofilaria). Molecular identification may be attempted on tissue specimens although this has not yet been successful in clinical cases.

Laboratory Safety

Standard precautions apply for the processing of tissue specimens.

Suggested Reading

Eberhard, M.L., Hellstein, J.W. and Lanzel, E.A., 2014. Zoonotic anatrichosomiasis in a mother and daughter. Journal of Clinical Microbiology, 52(8), pp.3127-3129.

Eberhard, M.L., Mathison, B., Bishop, H., Handoo, N.Q. and Hellstein, J.W., 2010. Zoonotic anatrichosomiasis in an Illinois resident. The American Journal of Tropical Medicine and Hygiene, 83(2), pp.342-344.

DPDx is an educational resource designed for health professionals and laboratory scientists. For an overview including prevention, control, and treatment visit www.cdc.gov/parasites/.