What to know
The tables below list the ICD-O-3 site codes, histology codes, and additional restrictions used to define and code the predefined SEER*Stat variables in the public use database.
Overview
Although cancer represents many heterogeneous diseases, some cancer types share common risk factors.1 For example, conclusive evidence links several cancers with alcohol use, human papillomavirus (HPV) infection, obesity, physical inactivity, and tobacco use.2 3 4 5 6
Cancer registries do not routinely collect risk factor information. So estimates for risk factor-associated cancers are based only on cancer type.
Using standard definitions for risk factor-associated cancers facilitates comparisons of cancer burden across states and communities. Although cancer may occur among people who were not exposed to a risk factor, population-based risk factor-associated cancer rates can help identify communities with high cancer rates. Clinical preventive services and community-based approaches can help reduce risk factors. Cancer surveillance data can track the effectiveness of these approaches.
The following tables list the International Classification of Disease for Oncology (ICD-O)-3 site codes, histology codes, and additional restrictions used to define and code the predefined SEER*Stat variables. Further restrictions may be made depending on the analysis. Refer to the SEER*Stat tutorial on merged variables for information on editing a merged variable.
| Cancer | ICD-O-3 site codes | ICD-O-3 histology codes | Additional restrictions |
|---|---|---|---|
| Lip, oral cavity, pharynx | C00.0–14.8 | 8000–9049, 9056–9139, 9141–9589 | |
| Esophagus | C15.0–15.9 | 8000–9049, 9056–9139, 9141–9589 | |
| Colon and rectum | C18.0–20.9, C26.0 | 8000–9049, 9056–9139, 9141–9589 | |
| Liver | C22.0 | 8000–9049, 9056–9139, 9141–9589 | |
| Larynx | C32.0–32.9 | 8000–9049, 9056–9139, 9141–9589 | |
| Female breast | C50.0–50.9 | 8000–9049, 9056–9139, 9141–9589 | Restrict to females |
| Cancer | ICD-O-3 site codes | ICD-O-3 histology codes | Additional restrictions |
|---|---|---|---|
| Oropharyngeal squamous cell carcinoma | C01.9, 02.4, 02.8, 05.1–05.2, 09.0–09.1, 09.8–09.9, 10.0–10.4, 10.8–10.9, 14.0, 14.2, 14.8 | 8050–8086, 8120–8131 | Restrict to microscopically confirmed |
| Anal and rectal squamous cell carcinoma | C21.0–21.8, 20.9 | 8050–8084, 8120–8131 | Restrict to microscopically confirmed |
| Vulvar squamous cell carcinoma | C51.0–51.9 | 8050–8084, 8120–8131 | Restrict to females and restrict to microscopically confirmed |
| Vaginal squamous cell carcinoma | C52.9 | 8050–8084, 8120–8131 | Restrict to females and restrict to microscopically confirmed |
| Cervical carcinoma | C53.0–53.9 | 8010–8671, 8940–8941 | Restrict to females and restrict to microscopically confirmed |
| Penile squamous cell carcinoma | C60.0–60.9 | 8050–8084, 8120–8131 | Restrict to males and restrict to microscopically confirmed |
| Cancer | ICD-O-3 site codes | ICD-O-3 histology codes | Additional restrictions |
|---|---|---|---|
| Esophageal adenocarcinoma | C15.0–15.9 | 8140–8575 | Restrict to microscopically confirmed |
| Gastric cardia | C16.0 | 8000-9049, 9056–9139, 9141–9589 | |
| Colon and rectum | C18.0–20.9, C26.0 | 8000–9049, 9056–9139, 9141–9589 | |
| Liver | C22.0 | 8000–9049, 9056–9139, 9141–9589 | |
| Gallbladder | C23.9 | 8000–9049, 9056–9139, 9141–9589 | |
| Pancreas | C25.0–25.9 | 8000–9049, 9056–9139, 9141–9589 | |
| Multiple myeloma | C42.1 | 9732 | |
| Postmenopausal female breast | C50.0–50.9 | 8000–9049, 9056–9139, 9141–9589 | Restrict to females and restrict to age ≥50 years |
| Corpus and uterus, NOS (not otherwise specified) | C54.0–54.9, C55.9 | 8000–9049, 9056–9139, 9141–9589 | Restrict to females |
| Ovary | C56.9 | 8000–9049, 9056–9139, 9141–9589 | Restrict to females |
| Kidney | C64.9 | 8000–9049, 9056–9139, 9141–9589 | |
| Meningioma | C70.0-70.1, 70.9 | 9530-9539 | |
| Thyroid | C73.9 | 8000–9049, 9056–9139, 9141–9589 |
| Cancer | ICD-O-3 site codes | ICD-O-3 histology codes | Additional restrictions |
|---|---|---|---|
| Colon | C18.0–18.9, C26.0 | 8000–9049, 9056–9139, 9141–9589 | |
| Postmenopausal female breast | C50.0–50.9 | 8000–9049, 9056–9139, 9141–9589 | Restrict to females and restrict to age ≥50 years |
| Corpus and uterus, NOS (not otherwise specified) | C54.0–54.9, C55.9 | 8000–9049, 9056–9139, 9141–9589 | Restrict to females |
| Cancer | ICD-O-3 site codes | ICD-O-3 histology codes | Additional restrictions |
|---|---|---|---|
| Lip, oral cavity, pharynx | C00.0–14.8 | 8000–9049, 9056–9139, 9141–9589 | |
| Esophagus | C15.0–15.9 | 8000–9049, 9056–9139, 9141–9589 | |
| Stomach | C16.0–16.9 | 8000–9049, 9056–9139, 9141–9589 | |
| Colon and rectum | C18.0–20.9, C26.0 | 8000–9049, 9056–9139, 9141–9589 | |
| Liver | C22.0 | 8000–9049, 9056–9139, 9141–9589 | |
| Pancreas | C25.0–25.9 | 8000–9049, 9056–9139, 9141–9589 | |
| Larynx | C32.0–32.9 | 8000–9049, 9056–9139, 9141–9589 | |
| Trachea, lung, bronchus | C33.9–34.9 | 8000–9049, 9056–9139, 9141–9589 | |
| Cervix uteri | C53.0–53.9 | 8000–9049, 9056–9139, 9141–9589 | Restrict to females |
| Kidney and renal pelvis | C64.9–65.9 | 8000–9049, 9056–9139, 9141–9589 | |
| Urinary bladder | C67.0–67.9 | 8000–9049, 9056–9139, 9141–9589 | |
| Acute myeloid leukemia | 9840; 9861; 9865–9869; 9871–9874; 9895–9898; 9910–9911; 9920 |
References
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2International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans: Volume 100E: Personal Habits and Indoor Combustions: Consumption of Alcoholic Beverages. Lyon, France: International Agency for Research on Cancer 2012;100E:373–499.
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5World Cancer Research Fund / American Institute for Cancer Research. Diet, Nutrition, Physical Activity and Cancer: A Global Perspective. Continuous Update Project Expert Report 2018.
6US Department of Health and Human Services. The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2014.
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11Centers for Disease Control and Prevention. Cancers linked with HPV each year. Atlanta, GA: U.S. Department of Health and Human Services. Accessed May 16, 2024.
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