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Table 7 – STI Treatment Guidelines
Guidelines for postexposure prophylaxis* of persons with nonoccupational exposure† to blood or body fluids that contain blood, by exposure type and hepatitis B vaccination status
| Source of exposure | Unvaccinated person§ | Previously vaccinated person¶ |
|---|---|---|
| HBsAg-positive source Percutaneous (e.g., bite or needlestick) or mucosal exposure to HBsAg-positive blood or body fluids or Sex or needle-sharing contact with an HBsAg-positive person or Victim of sexual assault or abuse by an assailant who is HBsAg positive |
Administer hepatitis B vaccine series and HBIG | Complete hepatitis B vaccine series and HBIG, if vaccine series not completed or Administer hepatitis B vaccine booster dose, if previous vaccination without testing** |
| Source with unknown HBsAg status Percutaneous (e.g., bite or needlestick) or mucosal exposure to potentially infectious blood or body fluids from a source with unknown HBsAg status or Sex or needle-sharing contact with person with unknown HBsAg status or Victim of sexual assault or abuse by a perpetrator with unknown HBsAg status |
Administer hepatitis B vaccine series | Complete hepatitis B vaccine series |
Sources: CDC. CDC guidance for evaluating health-care personnel for hepatitis B virus protection and for administering postexposure management. MMWR Recomm Rep 2013;62(No. RR-10); CDC. Postexposure prophylaxis to prevent hepatitis B virus infection. MMWR Recomm Rep 2006;55(No. RR-16).
Abbreviations: HBIG = hepatitis B immune globulin; HBsAg = hepatitis B surface antigen.
* When indicated, immunoprophylaxis should be initiated as soon as possible, preferably within 24 hours. Studies are limited regarding the maximum interval after exposure during which postexposure prophylaxis is effective, but the interval is unlikely to exceed 7 days for percutaneous exposures or 14 days for sexual exposures. The hepatitis B vaccine series should be completed. These guidelines apply to nonoccupational exposures.
† These guidelines apply to nonoccupational exposures.
§ A person who is in the process of being vaccinated but who has not completed the vaccine series should complete the series and receive treatment for hepatitis B as indicated.
¶ A person who has written documentation of a complete hepatitis B vaccine series and who did not receive postvaccination testing.
** No booster dose is needed for persons who have written documentation of hepatitis B vaccine series with serologic response.