Resistance or Elevated Minimum Inhibitory Concentration (MIC) Patterns of Neisseria gonorrhoeae Isolates to Antimicrobials, Gonococcal Isolate Surveillance Project (GISP), 2022

* Susceptible category includes isolates with penicillin (or Beta-lactamase negative), tetracycline, and ciprofloxacin MIC values that are not considered resistant (i.e., susceptible and intermediate resistant) based on Clinical & Laboratory Standards Institute criteria and isolates with ceftriaxone, cefixime, and azithromycin MIC values that are not considered elevated based on GISP “alert” values.

NOTE: Elevated MIC = Ceftriaxone: MIC ≥ 0.125 μg/mL; Cefixime: MIC ≥ 0.25 μg/mL; Azithromycin: MIC ≥ 2.0 μg/mL. Resistance = Tetracycline: MIC ≥ 2.0 μg/mL; Ciprofloxacin: MIC ≥ 1.0 μg/mL; Penicillin: MIC ≥ 2.0 μg/mL or Beta-lactamase positive. In the figure, a filled circle reflects resistance or elevated MIC to a specific antimicrobial; only antimicrobial combinations with non-zero percentages are shown.