At a glance
Sickle cell disease (SCD) is a group of inherited blood disorders associated with severe pain and complications that can affect the entire body. This page provides information on SCD and dactylitis (Hand-Foot Syndrome).
Overview
Painful swelling in the hands and feet is usually the first symptom of SCD in infants and toddlers. This swelling, often along with a fever, is caused by the sickled cells getting stuck in the blood vessels and blocking blood flow in the small bones of the hands and feet.