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Association of Depression With 10-Year and Lifetime Cardiovascular Disease Risk Among US Adults, National Health and Nutrition Examination Survey, 2005–2018

ORIGINAL RESEARCH — Volume 19 — May 26, 2022

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Figure. High (≥39%) lifetime cardiovascular disease risk prevalence, by sex and depression status, men and women aged 20 to 39 years, National Health and Nutrition Examination Survey, 2005–2018. Depression was measured by using the Patient Health Questionnaire-9 (PHQ-9). Depression was categorized as not depressed (score, 0–4), mild depression (score 5–9), and major depression (score ≥10). High lifetime risk was categorized with no exclusions for prior CVD (14). Percentages were weighted to represent the subpopulations but are otherwise unadjusted. The solid line is the percentage of high lifetime risk among men aged 20 to 39 years without depression (53.4% [95% CI, 51.1%–55.7%]); the dashed line is the percentage of high lifetime risk among women aged 20 to 39 years without depression (42.0% [95% CI, 39.9%–44.2%]). Error bars represent 95% CIs.

High (≥39%) lifetime cardiovascular disease risk prevalence, by sex and depression status, men and women aged 20 to 39 years, National Health and Nutrition Examination Survey, 2005–2018. Depression was measured by using the Patient Health Questionnaire-9 (PHQ-9). Depression was categorized as not depressed (score, 0–4), mild depression (score 5–9), and major depression (score ≥10). High lifetime risk was categorized with no exclusions for prior CVD (14). Percentages were weighted to represent the subpopulations but are otherwise unadjusted. The solid line is the percentage of high lifetime risk among men aged 20 to 39 years without depression (53.4% [95% CI, 51.1%–55.7%]); the dashed line is the percentage of high lifetime risk among women aged 20 to 39 years without depression (42.0% [95% CI, 39.9%–44.2%]). Error bars represent 95% CIs.
Depression status Men Women
% (95% CI)
No depression 53.4 (51.1–55.7) 42.0 (39.9–44.2)
Mild depression 63.9 (59.5–68.1) 52.4 (48.7–56.1)
Major depression 75.2 (69.0–80.6) 66.8 (61.3–71.8)

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