Validation of the Prevention Impacts Simulation Model (PRISM)
ORIGINAL RESEARCH — Volume 18 — February 4, 2021
PEER REVIEWED
This figure provides an overview of the model structure including the relationship between intervention strategies, risk factors, and outcomes.
Figure 1.
Diagram of the PRISM model. Abbreviations: CPAP, continuous positive airway pressure; CVD, cardiovascular disease; PRISM, Prevention Impacts Simulation Model.
Figure 2.
Results of 1-way sensitivity analysis of PRISM parameters that affected the impact of PRISM strategies on preventing cardiovascular deaths by more than ±0.5% compared with the estimated deaths averted from the base run (n = 15,672,020). Abbreviation: CVD, cardiovascular disease. (Minimum and maximum values used in 1-way sensitivity analysis are available upon request.)
Analysis | Cumulative CVD Deaths Averted (2018–2040) | |
---|---|---|
Lower Bound | Upper Bound | |
Multiplier for fruit/vegetable–poor diet from access | 15,592,960 | 15,975,310 |
Onset-reducing effect of clinically controlling prediabetes | 15,633,170 | 15,763,020 |
Multiplier on smoking quits from maximum marketing restriction | 15,540,520 | 15,725,640 |
Multiplier on smoking quits from maximum countermarketing | 15,540,520 | 15,725,640 |
Relative cardiovascular event fatality if distressed | 15,556,430 | 15,797,190 |
Onset-reducing effect of controlling borderline blood pressure | 15,648,570 | 15,941,810 |
Mitigating effect of quality CVD care for cardiovascular event risk | 15,489,010 | 15,859,030 |
Cardiovascular relative risk if fruit/vegetable–poor diet | 15,592,960 | 15,975,310 |
Relative cardiovascular events directly due to 2005 trans fat fraction | 15,426,820 | 15,969,070 |
Effect of quality acute and rehabilitation care on cardiovascular event fatality | 14,959,130 | 16,136,860 |
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