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o-Anisidine
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 90-04-0
NIOSH REL: 0.5 mg/m3 TWA [skin]; NIOSH considers o-anisidine to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
Current OSHA PEL: 0.5 mg/m3 TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 0.1 ppm (0.5 mg/m3) TWA [skin]
Description of substance: Red or yellow, oily liquid with an amine-like odor.
LEL: Unknown
Original (SCP) IDLH: 50 mg/m3
Basis for original (SCP) IDLH: Because no data on acute inhalation toxicity are available for anisidine (o-, p-isomers), the chosen IDLH is based on chronic data. ACGIH [1971] reported that mice survived exposures to 10 to 30 mg/m3 for 2 hours/day, 6 days/week for 1 month; a decrease in the excitability of nerves was noted [Zaeva and Fedorova 1962]. Because mice survived 30 mg/m3, 2 hours/day, 6 days/week for 1 month, a worker should be able to escape from 50 mg/m3 without injury or irreversible health effects.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived Value |
|---|---|---|---|---|---|---|
| Rat | IARC 1982 | oral | 2,000 | —– | 14,000 mg/m3 | 1,400 mg/m3 |
| Mouse | IARC 1982 | oral | 1,400 | —– | 9,800 mg/m3 | 980 mg/m3 |
| Rabbit | IARC 1982 | oral | 870 | —– | 6,090 mg/m3 | 609 mg/m3 |
Other animal data: Mice have survived exposures to concentrations of 10 to 30 mg/m3 for 2 hours/day, 6 days/week for 1 month with only a decrease in the excitability of nerves noted [Zaeva and Fedorova 1962].
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 50 mg/m3 [Unchanged]Basis for revised IDLH: Based on subchronic inhalation toxicity data in animals [Zaeva and Fedorova 1962], the original IDLH for o-anisidine (50 mg/m3) is not being revised at this time. [Note: NIOSH recommends as part of its carcinogen policy that the “most protective” respirators be worn for o-anisidine at concentrations above 0.5 mg/m3.] |
REFERENCES:
- ACGIH [1971]. Anisidine (o-, p-isomers). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 14.
- IARC [1982]. IARC monographs on the evaluation of carcinogenic risk of chemicals to humans. Vol. 27. Lyon, France: World Health Organization, International Agency for Research on Cancer, p. 63.
- Zaeva GN, Fedorova VI [1962]. Toxsikol Nov Prom Khim Vesh 4:91 (in Russian).