An official website of the United States government
Perchloryl fluoride
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 7616–94–6
NIOSH REL: 3 ppm (14 mg/m3) TWA, 6 ppm (28 mg/m3) STEL
Current OSHA PEL: 3 ppm (13.5 mg/m3) TWA
1989 OSHA PEL: 3 ppm (14 mg/m3) TWA, 6 ppm (28 mg/m3) STEL
1993-1994 ACGIH TLV: 3 ppm (13 mg/m3) TWA, 6 ppm (25 mg/m3) STEL
Description of substance: Colorless gas with a characteristic, sweet odor.
LEL: . . Nonflammable Gas
Original (SCP) IDLH: 385 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the rat 4-hour LC50 of 385 ppm [Greene et al. 1960 cited by ACGIH 1971].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
| Species | Reference | LC50 (ppm) | LCLo (ppm) | Time | Adjusted 0.5-hr LC (CF) | Derived value |
|---|---|---|---|---|---|---|
| RatRat
Mouse Dog |
Dost et al. 1974Greene et al. 1960
Greene et al. 1960 Jacobson 1958 |
—–385
630 —– |
2,000—–
—– 451 |
40 min4 hr
4 hr 4 hr |
2,200 ppm (1.1)770 ppm (2.0)
1,260 ppm (2.0) 902 ppm (2.0) |
220 ppm77 ppm
126 ppm 90 ppm |
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 100 ppmBasis for revised IDLH: The revised IDLH for perchloryl fluoride is 100 ppm based on acute inhalation toxicity data in animals [Greene et al. 1960; Jacobson 1958]. |
REFERENCES:
1. ACGIH [1971]. Perchloryl fluoride. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 202-203.
2. Dost FN, Reed DJ, Smith VN, Wang CH [1974]. Toxic properties of chlorine trifluoride. Toxicol Appl Pharmacol 27:527-536.
3. Greene EA, Colbourn JL, Donati E, Weeks MH [1960]. The inhalation toxicity of perchloryl fluoride. Army Chemical Center, Maryland: U.S. Army Chemical Research and Development Laboratories, Technical Report No. CRDLR 3010, p. 9.
4. Jacobson KH [1958]. Transactions of the Symposium on Health Hazards of Military Chemicals. Army Chemical Center, MD: Directorate of Medical Research, U.S. Army Chemical Warfare Laboratories, CWL Special Publication 2-10.