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Dieldrin
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 60–57–1
NIOSH REL: 0.25 mg/m3 TWA [skin]; NIOSH considers dieldrin to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
Current OSHA PEL: 0.25 mg/m3 TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 0.25 mg/m3 TWA [skin]
Description of Substance: Colorless to light-tan crystals with a mild, chemical odor.
LEL:. . Noncombustible Solid
Original (SCP) IDLH: 450 mg/m3
Basis for original (SCP) IDLH: No data on acute inhalation toxicity are available on which to base the IDLH for dieldrin. The chosen IDLH, therefore, has been estimated from the statement by Deichmann and Gerarde [1969] that an oral dose of 65 mg/kg is believed to be a reasonable estimate of the lethal dose in man. Thienes and Haley [1972] and Gleason et al. [1969] reported similar estimates of the lethal dose for man [Hodge et al. 1967; Kalushner 1960].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50 | LCLo | Time | Adjusted 0.5-hrLC (CF) | Derivedvalue |
|---|---|---|---|---|---|---|
| CatRat | Gig Tr Prof Zabol 1964Izmerov et al. 1982 | 80 mg/m313 mg/m3 | ———- | 4 hr4 hr | 160 mg/m3 (2.0)26 mg/m3 (2.0) | 16 mg/m32.6 mg/m3 |
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| RabbitG. pig
Mouse Dog Rat |
AAPCO 1966AAPCO 1966
Kenaga and Morgan 1978 Spencer 1973 Treon and Cleveland 1955 |
oraloral
oral oral oral |
4549
38 65 38 |
———-
—– —– —– |
315 mg/m3343 mg/m3
266 mg/m3 455 mg/m3 266 mg/m3 |
32 mg/m334 mg/m3
27 mg/m3 46 mg/m3 27 mg/m3 |
Human data: The lethal oral dose has been estimated to be about 5 grams [Deichmann and Gerarde 1969; Hodge et al. 1967]. [Note: An oral dose of 5 grams is equivalent to a worker being exposed to 3,300 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
| Revised IDLH: 50 mg/m3Basis for revised IDLH: The revised IDLH for dieldrin is 50 mg/m3 based on acute oral toxicity data in humans [Deichmann and Gerarde 1969; Hodge et al. 1967]. [Note: NIOSH recommends as part of its carcinogen policy that the “most protective” respirators be worn for dieldrin at concentrations above 0.25 mg/m3.] |
REFERENCES:
1. AAPCO [1966]. Pesticide chemicals official compendium. Topeka, KS: Association of American Pesticide Control Officials, Inc., p. 377.
2. Deichmann WB, Gerarde HW [1969]. Dieldrin. In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., pp. 215-216.
3. Gig Tr Prof Zabol [1964]; 8(4):30-34 (in Russian).
4. Gleason MN, Gosselin RE, Hodge HC, Smith RP [1969]. Clinical toxicology of commercial products. 3rd ed. Baltimore, MD: Williams & Wilkins Company, pp. 85-87.
5. Hodge HC, Boyce AM, Deichmann WB, Kraybill HF [1967]. Toxicology and no-effect levels of aldrin and dieldrin. Toxicol Appl Pharmacol 10:613-675.
6. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 73.
7. Kalushner A [1960]. Occupational dieldrin poisoning. JAMA 172(18):148-151.
8. Kenaga EE, Morgan RW [1978]. Commercial and experimental organic insecticides. Entomological Society of America Special Publication 78-1:13.
9. Spencer EY [1973]. Guide to the chemicals used in crop protection. 6th ed. London, Ontario, Canada: Research Institute, University of Western Ontario Sub Post Office, p. 13.
10. Thienes CH, Haley TJ [1972]. Clinical toxicology. 5th ed. Philadelphia, PA: Lea & Febiger, p. 26.
11. Treon JF, Cleveland FP [1955]. Toxicity of certain chlorinated hydrocarbon insecticides for laboratory animals. J Agri Food Chem 3:402-403.