Aldrin
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 309-00-2
NIOSH REL: 0.25 mg/m3 TWA [skin]; NIOSH considers aldrin to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
Current OSHA PEL: 0.25 mg/m3 TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 0.25 mg/m3 TWA [skin]
Description of substance: Colorless to dark-brown crystalline solid with a mild chemical odor.
LEL: Noncombustible Solid
Original (SCP) IDLH: 100 mg/m3
Basis for original (SCP) IDLH: No useful data on acute inhalation toxicity are available on which to base the IDLH for aldrin. The chosen IDLH, therefore, has been estimated from the statement by Baskin [1975] that severe symptoms follow swallowing or skin contamination with 15 to 50 mg/kg (average adult). According to Deichmann [1973], aldrin vapor gave no effect in man at 18 mg/m3 during exposure for 1 day.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
Adjusted | ||||||
---|---|---|---|---|---|---|
LC50 | LCLo | 0.5-hr | Derived | |||
Species | Reference | (ppm) | (ppm) | Time | LC (CF) | Value |
Rat | Izmerov et al. 1982 | —– | 5.8 mg/m3 | 4 hr | 12 mg/m3 (2.0) | 1.2 mg/m3 |
Lethal dose data:
LL50 | LCLo | Derived | ||||
---|---|---|---|---|---|---|
Species | Reference | Route | (mg/kg) | (mg/kg) | Adjusted LD | Value |
Rabbit | AAPCO 1966 | oral | 50 | —– | 350 mg/m3 | 35 mg/m3 |
G. pig | AAPCO 1966 | oral | 33 | —– | 231 mg/m3 | 23 mg/m3 |
Rat | Kenaga and Morgan 1978 | oral | 39 | —– | 273 mg/m3 | 27 mg/m3 |
Mouse | Kenaga and Morgan 1978 | oral | 44 | —– | 308 mg/m3 | 31 mg/m3 |
Human data: No effects were noted after exposure to 18 mg/m3 for 1 day [Deichmann 1973]. Ingestion of 25.6 mg/kg caused convulsions within 20 minutes [Ottolenghi et al. 1974]. [Note: An oral dose of 25.6 mg/kg is equivalent to a 70-kg worker being exposed to about 1,200 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
Revised IDLH: 25 mg/m3Basis for revised IDLH: The revised IDLH for aldrin is 25 mg/m3 based on acute toxicity data in humans [Deichmann 1973; Ottolenghi et al. 1974]. [Note: NIOSH recommends as part of its carcinogen policy that the “most protective” respirators be worn for aldrin at concentrations above 0.25 mg/m3.] |
References:
- AAPCO [1966]. Pesticide chemicals official compendium. Topeka, KS: Association of American Pesticide Control Officials, Inc., p. 7.
- Baskin AD, ed. [1975]. Handling guide for potentially hazardous materials. Oxford, IN: The Richard B. Cross Company, PC 0180.
- Deichmann WB [1973]. The chronic toxicity of organochlorine pesticides in man. In: Pesticides and the environment: a continuing controversy. Vol. II. New York, NY: Intercontinental Medical Book Corporation, pp. 347-420.
- Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 73.
- Kenaga EE, Morgan RW [1978]. Commercial and experimental organic insecticides (1978 revision). Entomological Society of America Special Publication 78-1:12.
- Ottolenghi AD, Haseman JK, Suggs F [1974]. Teratogenic effects of aldrin, dieldrin, and endrin in hamsters and mice. Teratology 9:11.