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Diglycidyl ether
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 2238–07–5
NIOSH REL: 0.1 ppm (0.5 mg/m3) TWA; NIOSH considers diglycidyl ether to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].
Current OSHA PEL: 0.5 ppm (2.8 mg/m3) CEILING
1989 OSHA PEL: 0.1 ppm (0.5 mg/m3) TWA
1993-1994 ACGIH TLV: 0.1 ppm (0.53 mg/m3) TWA
Description of Substance: Colorless liquid with a strong, irritating odor.
LEL:. . Unknown
Original (SCP) IDLH: 25 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the male mouse 4-hour LC50 of 30 ppm [Hine et al. 1956].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derivedvalue |
|---|---|---|---|---|---|---|
| MouseMouse
Mouse Rat Rat Rat |
Hine et al. 1956Hine et al. 1961
Hine et al. 1961 Hine et al. 1961 Hine et al. 1961 Marhold 1986 |
3086
30 200 68 200 |
———-
—– —– —– —– |
4 hr4 hr
8 hr 4 hr 8 hr 4 hr |
60 ppm (2.0)192 ppm (2.0)
75 ppm (2.5) 400 ppm (2.0) 170 ppm (2.5) 400 ppm (2.0) |
6.0 ppm19 ppm
7.5 ppm 40 ppm 17 ppm 40 ppm |
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 10 ppmBasis for revised IDLH: The revised IDLH for diglycidyl ether is 10 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956; Hine et al. 1961]. [Note: NIOSH recommends as part of its carcinogen policy that the “most protective” respirators be worn for diglycidyl ether at concentrations above 0.1 ppm.] |
REFERENCES:
1. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250-264.
2. Hine CH, Kodama JK, Guzman RJ, Dunlap MK, Lima R, Loquvam GS [1961]. Effects of diglycidyl ether on blood of animals. Arch Environ Health 2(1):37/31-50/44.
3. Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 773 (in Czechoslovakian).