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Methyl Cellosolve® acetate
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 110–49–6
NIOSH REL: 0.1 ppm (0.5 mg/m3 TWA [skin]
Current OSHA PEL: 25 ppm (120 mg/m3) TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 5 ppm (24 mg/m3) TWA [skin]
Description of substance: Colorless liquid with a mild, ether-like odor.
LEL: . . 1.7% (10% LEL, 1,700 ppm)
Original (SCP) IDLH: 4,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on an analogy with methyl methacrylate which has an IDLH of 4,000 ppm.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derived value |
|---|---|---|---|---|---|---|
| Cat | Flury & Wirth 1933 | —– | 1,222 | 7 hr | 2,933 ppm (2.4) | 293 ppm |
| Rat | Smyth & Carpenter 1948 | —– | 7,000 | 4 hr | 14,000 ppm (2.0) | 1,400 ppm |
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| Rat | Smyth & Carpenter 1948 | oral | 3,390 | —– | 4,833 ppm | 483 ppm |
| G. pig | Smyth et al. 1941 | oral | 1,250 | —– | 1,782 ppm | 178 ppm |
Human data: It has been stated that methyl Cellosolve® acetate is slightly less toxic than methyl Cellosolve® [Gosselin et al. 1984].
| Revised IDLH: 200 ppmBasis for revised IDLH: Based on health considerations and acute inhalation toxicity data in animals [Flury and Wirth 1933; Smyth and Carpenter 1948], a value of about 1,000 ppm would have been appropriate for methyl Cellosolve® acetate. However, the revised IDLH for methyl Cellosolve® acetate is 200 ppm based on being 2,000 times the current NIOSH REL of 0.1 ppm (2,000 is an assigned protection factor for respirators; only the most reliable respirators are recommended above 2,000 times the NIOSH REL). |
REFERENCES:
1. Flury F, Wirth W [1933]. Zur toxikologie der lösungsmittel (Verschieden ester, aceton, methylalkohol). Arch Gewerbepath Gewerbehyg 5:1-90 (in German).
2. Gosselin RF, Smith RP, Hodge HC [1984]. Clinical toxicology of commercial products. 5th ed. Baltimore, MD: Williams & Wilkins Company, p. II-183.
3. Smyth HF Jr, Carpenter CP [1948]. Further experience with the range finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol 30:63-68.
4. Smyth HF Jr, Seaton J, Fischer L [1941]. The single dose toxicity of some glycols and derivatives. J Ind Hyg Toxicol 23:259-268.