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sec-Hexyl acetate
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 108–84–9
NIOSH REL: 50 ppm (300 mg/m3) TWA
Current OSHA PEL: 50 ppm (300 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 50 ppm (295 mg/m3) TWA
Description of Substance: Colorless liquid with a mild, pleasant, fruity odor.
LEL:. . Unknown
Original (SCP) IDLH: 4,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that 2 of 6 rats died from a 4-hour exposure to 4,000 ppm [Smyth et al. 1954].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derivedvalue |
|---|---|---|---|---|---|---|
| RatRat | Smyth et al. 1954UCC 1966 | LC33: 4,000—– | —–2,000 | 4 hr4 hr | 8,000 ppm (2.0)4,000 ppm (2.0) | 800 ppm400 ppm |
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| Rat | UCC 1966 | oral | 6,160 | —– | 7,187 ppm | 719 ppm |
Human data: Volunteers noted an unpleasant odor and irritation of the eyes and upper respiratory tract at 100 ppm [Silverman et al. 1946].
| Revised IDLH: 500 ppmBasis for revised IDLH: The revised IDLH for sec-hexyl acetate is 500 ppm based on acute inhalation toxicity data in humans [Silverman et al. 1946] and animals [Smyth et al. 1954; UCC 1966]. |
REFERENCES:
1. ACGIH [1971]. sec-Hexyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 127.
2. Silverman L, Schulte HF, First MW [1946]. Further studies on sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol 28:262-266.
3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61-68.
4. UCC [1966]. Toxicology studies: methyl amyl acetate. New York, NY: Union Carbide Corporation, Industrial Medicine and Toxicology Department (7/28/66).