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Isopropyl ether
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 108–20–3
NIOSH REL: 500 ppm (2,100 mg/m3) TWA
Current OSHA PEL: 500 ppm (2,100 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 250 ppm (1,040 mg/m3) TWA, 310 ppm (1,300 mg/m3) STEL
Description of substance: Colorless liquid with a sharp, sweet, ether-like odor.
LEL: . . 1.4% (10% LEL, 1,400 ppm)
Original (SCP) IDLH: 10,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1968] report that breathing the vapors in a state approaching saturation in room air killed all rats in a 10-minute exposure. [Note: Based on a vapor pressure of 119 mmHg [Patty 1963], the saturated concentration of isopropyl ether in air at 20°C is about 157,000 ppm.] Breathing 8,000 ppm was not fatal after a 4-hour exposure, but 16,000 ppm killed 6 of 6 animals exposed for the same period of time [UCC 1968].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derived value |
|---|---|---|---|---|---|---|
| Rat | Pavlova et al. 1963 | 38,138 | —– | ? | ? | ? |
| Rabbit | Pavlova et al. 1963 | 30,840 | —– | ? | ? | ? |
| Rabbit | Pavlova et al. 1963 | 28,486 | —– | ? | ? | ? |
| Rat | UCC 1968 | LC100: 157,000 | —– | 10 min | 105,190 ppm (0.67) | 10,519 ppm |
| Mammal | UCC 1968 | LC100: 16,000 | —– | 4 hr | 32,000 ppm (2.0) | 3,200 ppm |
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| Rabbit | Machle et al. 1939 | oral | —– | 5,000-6,500 | 8,235-10,706 ppm | 824-1,071 ppm |
| Rat | UCC 1968 | oral | 8,470 | —– | 13,951 ppm | 1,395 ppm |
Other animal data: It has been reported that animals survived a 4-hour exposure to 8,000 ppm [UCC 1968].
Human data: Volunteers exposed to 800 ppm for 5 minutes reported irritation of the eyes and nose [Silverman et al. 1946].
| Revised IDLH: 1,400 ppm [LEL]Basis for revised IDLH: Based on health considerations and acute inhalation toxicity data in animals [UCC 1968], a value of about 3,200 ppm would have been appropriate for isopropyl ether. However, the revised IDLH for isopropyl ether is 1,400 ppm based strictly on safety considerations (i.e., being 10% of the lower explosive limit of 1.4%). |
REFERENCES:
1. Machle W, Scott EW, Treon J [1939]. The physiological response to isopropyl ether and to a mixture of isopropyl ether and gasoline. J Ind Hyg Toxicol 21:72-96.
2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1662.
3. Pavlova LP, Lagunova VV, Imanov RM [1963]. Determination of the maximal permissible concentration of diisopropyl ether in the air of working zone. Gig Tr Prof Zabol 19(10):55-57 (in Russian).
4. Silverman L, Schulte HF, First MW [1946]. Further studies on sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol 28:262-266.
5. UCC [1968]. Toxicology studies: isopropyl ether. New York, NY: Union Carbide Corporation.