Skin Notation Strategy
April 2010
NIOSH Docket Number 153-A
Historically, skin notations have been published in the NIOSH Pocket Guide to Chemical Hazards. This practice will continue with the NIOSH skin notation assignments for each evaluated chemical being integrated as they become available. A support document called a Skin Notation Profile has been developed for each evaluated chemical. The Skin Notation Profile for a chemical is intended to provide information supplemental to the skin notation, including a summary of all relevant data used to aid in determining the hazards associated with skin exposures.
NIOSH obtained comments on the draft skin notation assignments and Skin Notation Profiles for 22 chemicals. The submissions are listed below.
Note: To view the final Skin Notation Profiles visit the Skin Notation Profiles website .
Background Information
Revised Final Document: NIOSH Current Intelligence Bulletin (CIB): 61: A strategy for Assigning New NIOSH Skin Notations – 8/1/17 [PDF – 2 MB]
Final document: NIOSH Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations; 2009-147 – 7/1/09
Peer reviewer summary of comments – 06/01/10 [PDF – 3,712 KB]
Notice of public comment period; 75 FR 22148 – 04/27/10 [PDF – 3,628 KB]
Charge to Reviewers – 04/27/10 [PDF – 1,287 KB]
Peer Reviewer Submissions on 22 Chemicals (in Numerical Order)
- A-01 1, 3-Dichloropropene (CAS # 542–75–6): Submission to the docket from peer reviewers on 1,3-Dichloropropene – 06/01/10 [PDF – 3,483 KB]
- A-02 Phenol (CAS # 108–95–2): Submission to the docket from peer reviewers on Phenol – 06/01/10 [PDF – 2,381 KB]
- A-03 Hydrogen fluoride/hydrofluoric acid (CAS # 7664–39–3): Submission to the docket from peer reviewers on Hydrogen fluoride/hydrofluoric acid – 06/01/10 [PDF – 2,552 KB]
- A-04 Dinitrotoluene (CAS # 25321–14–6); 2,4–; (CAS # 121–14–2); 2,6–; (CAS # 606–20–2): Submission to the docket from peer reviewers on Dinitrotoluene – 06/01/10 [PDF – 4,410 KB]
- A-05 Acrylamide (CAS # 79–06–1): Submission to the docket from peer reviewers on Acrylamide – 06/01/10 [PDF – 1,516 KB]
- A-06 Acrylonitrile (CAS # 107–13–1): Submission to the docket from peer reviewers on Acrylonitrile – 06/01/10 [PDF – 1,673 KB]
- A-07 Metallic Chromium and other Substances containing Hexavalent Chromium [Cr(VI)] CAS # 7440–47–3; 18540–29–9: Submission to the docket from peer reviewers on Metallic Chromium and other Substances containing Hexavalent Chromium (Cr(VI)) – 06/01/10 [PDF – 3,095 KB]
- A-08 m,p,o-Dinitrobenzene (CAS # 99–65–0; 58–29–0; 100–25–4): Submission to the docket from peer reviewers on m,p,o-Dinitrobenzene – 06/01/10 [PDF – 2,327 KB]
- A-09 Epichlorohydrin (CAS # 106–89–8): Submission to the docket from peer reviewers on Epichlorohydrin – 06/01/10 [PDF – 1,971 KB]
- A-10 Ethylene glycol dinitrate (CAS # 628–96–6): Submission to the docket from peer reviewers on Ethylene glycol dinitrate – 06/01/10 [PDF – 2,642 KB]
- A-11 Bisphenol A (CAS # 80–05–7): Submission to the docket from peer reviewers on Bisphenol A – 06/01/10 [PDF – 2,428 KB]
- A-12 Formaldehyde (CAS # 50–00–0): Submission to the docket from peer reviewers on Formaldehyde – 06/01/10 [PDF – 3,426 KB]
- A-13 Hydrazine (CAS # 302–01–2): Submission to the docket from peer reviewers on Hydrazine – 06/01/10 [PDF – 2,343 KB]
- A-14 Nitroglycerin (CAS # 55–63–0): Submission to the docket from peer reviewers on Nitroglycerin – 06/01/10 [PDF – 2,461 KB]
- A-15 Nonane (CAS # 111–84–2): Submission to the docket from peer reviewers on Nonane – 06/01/10 [PDF – 1,937 KB]
- A-16 Glutaraldehyde (CAS # 111–30–8): Submission to the docket from peer reviewers on Glutaraldehyde – 06/01/10 [PDF – 2,556 KB]
- A-17 Sodium hydroxide (CAS # 1310–73–2): Submission to the docket from peer reviewers on Sodium hydroxide – 06/01/10 [PDF – 2,354 KB]
- A-18 Trichloroethylene (CAS # 79–01–6): Submission to the docket from peer reviewers on Trichloroethylene – 06/01/10 [PDF – 3,277 KB]
- A-19 Methyl cellosolve (CAS # 109–86–4): Submission to the docket from peer reviewers on Methyl cellosolve – 06/01/10 [PDF – 2,958 KB]
- A-20 2-Butoxyethanol (CAS # 111–76–2): Submission to the docket from peer reviewers on 2-Butoxyethanol – 06/01/10 [PDF – 2,619 KB]
- A-21 2-Ethoxyethanol (CAS # 110–80–5): Submission to the docket from peer reviewers on 2-Ethoxyethanol – 06/01/10 [PDF – 2,055 KB]
- A-22 p-Phenylenediamine (CAS # 106–50–3): Submission to the docket from peer reviewers on p-Phenylenediamine – 06/01/10 [PDF – 1,920 KB]
Submissions in Numerical Order
Submission to Docket Office from Kristy Morrison (American Chemistry Council) on A-03; 06/11/10 [PDF – 2,153 KB]
Submission to Docket Office from Markku Huvienen and Grant Darrie (International Chromium Development Association) on A-07; 05/12/10 [PDF – 2,941 KB]
Submission to Docket Office from John Wittenborn (Counsel to the Specialty Steel Industry of North American) on A-07; 06/10/10 [PDF – 2,443 KB]
Submission to Docket Office from Paul Dugard (Halogenated Solvents Industry Alliance Inc) on A-18; w/3 attachments; 06/11/10 [PDF – 1,922 KB]
Peer review
Title: NIOSH Skin Notation (SK) Profiles: Group A (22 Technical Reports)
Subject: Technical assessment of the potential hazards of skin contact with chemicals and assignment of hazard-specific skin notations (SK) based on review.
Purpose: To assess the potential hazards of skin contact with selected chemicals following the decision logic and strategy presented in NIOSH Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009-147] and develop hazard-specific skin notation (SK) assignments based on the critical review of available scientific data.
Type of Dissemination: Printed document and web posting.
Timing of Review: May-July 2010
Primary Disciplines or Expertise Needed for Review: Human health risk assessment, toxicology, epidemiology, industrial hygiene, health sciences
Type of Review: Individual
Number of Reviewers: 24, 2 of those assigned to each technical report
Reviewers Selected by: NIOSH
Public Nominations Requested for Reviewers: No
Opportunities for the Public to Comment: Yes
Peer Reviewers Provided with Public Comments before Their Review: Yes
Peer Reviewers
- Bryan E. Anderson
Academic and Professional Credentials: MD
Organizational Affiliation: Assistant Professor, Department of Dermatology
Penn State College of Medicine, Hersey. PA
Areas of Expertise, Discipline, or Relevant Experience: Dermatology
Recommended by: NIOSH - Ronald Baynes
Academic and Professional Credentials: MD
Organizational Affiliation: Associate Professor, College of Veterinary Medicine, North Carolina State University, Raleigh, NC
Areas of Expertise, Discipline, or Relevant Experience: Pharmacology
Recommended by: NIOSH - Frank Barile
Academic and Professional Credentials: PhD
Organizational Affiliation: Professor, Epidemiology, Department of Pharmaceutical Sciences, St. Johns University, Queens, NY
Areas of Expertise, Discipline, or Relevant Experience: Toxicology/Pharmacology
Recommended by: NIOSH - Phillip J. Bigelow
Academic and Professional Credentials: PhD, CIH
Organizational Affiliation: Associate Professor, Department of Health Studies and Gerontology, University of Waterloo, Waterloo, Canda
Areas of Expertise, Discipline, or Relevant Experience: Pharmacology
Recommended by: NIOSH - John Cherrie
Academic and Professional Credentials: PhD
Organizational Affiliation: Research Director, Institute of Occupational Medicine, Edinburgh, Scotland
Areas of Expertise, Discipline, or Relevant Experience: Industrial Hygiene, Exposure Assessment
Recommended by: NIOSH - Laura Deakin
Academic and Professional Credentials: PhD
Organizational Affiliation: Associate Professor, Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada
Areas of Expertise, Discipline, or Relevant Experience: Chemistry, Public Health
Recommended by: NIOSH - Joshua Gray
Academic and Professional Credentials: PhD
Organizational Affiliation: Associate Professor, Department of Pharmacology & Toxicology, Rutgers University, New London, CT
Areas of Expertise, Discipline, or Relevant Experience: Dermal Toxicology
Recommended by: NIOSH - Diane E. Heck
Academic and Professional Credentials: PhD
Organizational Affiliation: Professor and Chair, Department of Environmental Health Science, School of Health Sciences and Practice, New York Medical College, Valhalla, NY
Areas of Expertise, Discipline, or Relevant Experience: Toxicology
Recommended by: NIOSH - John Herbold
Academic and Professional Credentials: PhD
Organizational Affiliation: School of Public Health, University of Texas, San Antonio, TX
Areas of Expertise, Discipline, or Relevant Experience: Toxicology, Epidemiology
Recommended by: NIOSH - Randal J. Keller
Academic and Professional Credentials: PhD, CIH, CSP,DABT
Organizational Affiliation: Professor, Department of Occupational Safety and Health, Murray State University, Murray, KY
Areas of Expertise, Discipline, or Relevant Experience: Toxicology, Industrial Hygiene
Recommended by: NIOSH - Youcheng Liu
Academic and Professional Credentials: MD, ScD, MPH
Organizational Affiliation: Assistant Professor, Department of Preventive Medicine and Environmental Health College of Public Health, University of Kentucky, Lexington, KY
Areas of Expertise, Discipline, or Relevant Experience: Exposure Assessment, Industrial Hygiene
Recommended by: NIOSH - William E. Luttrell
Academic and Professional Credentials: PhD, CIH
Organizational Affiliation: Associate Professor of Chemistry and Chair, Department of Chemistry and Physics, Oklahoma Christian University, Edmond, Oklahoma
Areas of Expertise, Discipline, or Relevant Experience: Exposure Assessment, Industrial Hygiene
Recommended by: NIOSH - Howard Maibach
Academic and Professional Credentials: PhD
Organizational Affiliation: Professor, Department of Dermatology, University of California-San Francisco, San Francisco, CA
Areas of Expertise, Discipline, or Relevant Experience: Dermatology, Dermal Toxicology
Recommended by: NIOSH - James N. McDougal
Academic and Professional Credentials: PhD
Organizational Affiliation: Professor and Director of Toxicology Research, Department of Pharmacology and Toxicology, Wright State University, Dayton, OH
Areas of Expertise, Discipline, or Relevant Experience: Dermal Toxicology
Recommended by: NIOSH - Nancy Monterio-Riviere
Academic and Professional Credentials: PhD
Organizational Affiliation: Professor, Center for Chemical Toxicology Research and Pharmacokinetics, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC
Areas of Expertise, Discipline, or Relevant Experience: Dermal Toxicology
Recommended by: NIOSH - Hasan Mukhtar
Academic and Professional Credentials: PhD
Organizational Affiliation: Professor, Department of Dermatology, University of Wisconsin, Madison, Wisconsin
Areas of Expertise, Discipline, or Relevant Experience: Dermal Pharmacology, Dermal Toxicology
Recommended by: NIOSH - Alfred M. Nyanda
Academic and Professional Credentials: PhD
Organizational Affiliation: Professor, Department of Medical & Professional Education, Meharry Medical College, Nashville, TN
Areas of Expertise, Discipline, or Relevant Experience: Pharmacology
Recommended by: NIOSH - Leena Nyanda-French
Academic and Professional Credentials: PhD, CIH
Organizational Affiliation: Professor, Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC
Areas of Expertise, Discipline, or Relevant Experience: Industrial Hygiene, Exposure Assessment
Recommended by: NIOSH - Mai A. Ngo
Academic and Professional Credentials: PhD
Organizational Affiliation: Researcher, Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, CA
Areas of Expertise, Discipline, or Relevant Experience: Dermal Toxicology
Recommended by: NIOSH - Shane S. Que Hee
Academic and Professional Credentials: PhD
Organizational Affiliation: Professor, Department of Environmental Health Sciences, School of Public Health, University of California-Los Angeles, Los Angeles, CA
Areas of Expertise, Discipline, or Relevant Experience: Environmental Health Sciences, Industrial Hygiene
Recommended by: NIOSH - Gloria Post
Academic and Professional Credentials: PhD, DABT
Organizational Affiliation: Research Scientist, Office of Science, New Jersey Department of Environmental Protection, Trenton, NJ
Areas of Expertise, Discipline, or Relevant Experience: Toxicology
Recommended by: NIOSH - Jim E. Riviere
Academic and Professional Credentials: DVM, PhD, DSc, ATS
Organizational Affiliation: Professor and Director, Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, Raleigh, NC
Areas of Expertise, Discipline, or Relevant Experience: Toxicology, Pathobiology
Recommended by: NIOSH - Carrie Redlich
Academic and Professional Credentials: MD, MPH
Organizational Affiliation: Yale Occupational and Environmental Medicine Program, School of Medicine, Yale University, New Haven, CT
Areas of Expertise, Discipline, or Relevant Experience: Occupational Medicine
Recommended by: NIOSH - Katherine S. Squibb
Academic and Professional Credentials: PhD
Organizational Affiliation: Professor of Medicine, University of Maryland School of Medicine, Baltimore, MD
Areas of Expertise, Discipline, or Relevant Experience: Toxicology
Recommended by: NIOSH