Vinyl fluoride
RTECS #
YZ7351000
CAS #
Updated
March 2018
Molecular Weight
46.05
Molecular Formula
C2H3F
Synonyms
Ethene, fluoro-
Ethylene, fluoro- (8CI)
Fluoroethene
Fluoroethylene
Fluoroethylene (IUPAC)
Monofluoroethene
Monofluoroethylene
Ethylene, fluoro- (8CI)
Fluoroethene
Fluoroethylene
Fluoroethylene (IUPAC)
Monofluoroethene
Monofluoroethylene
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| micronucleus test | inhalation/mouse | 19100 ppm/6H-continuous | EMMUEG 19(Suppl 20),5,1992 |
| morphological transform | inhalation/rat | 2000 ppm/14W- intermittent | ARTODN 47,71,1981 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 25 ppm/6H/1.5Y- intermittent | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors | NTIS** OTS0538078 |
| inhalation/rat | lowest published toxic concentration: 2500 ppm/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Skin and Appendages: Tumors | NTIS** OTS0538078 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | Lethal concentration: >80 pph/12.5H | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Dyspnea | AIHOAX 2(3),335,1950 |
| inhalation/rat | lethal concentration (50 percent kill): 1600000 mg/m3/4H | VCVGH* -,286,1990 | |
| inhalation/rat | lowest published toxic concentration: 864 mg/m3/30M | Behavioral: General anesthetic | VCVGH* -,286,1990 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 20000 ppm/6H/13W- intermittent | Olfaction: Other olfaction effects Liver: Other changes Kidney, Ureter, and Bladder: Other changes in urine composition | NTIS** OTS0522820 |
| inhalation/rat | lowest published toxic concentration: 2000 ppm/6H/13W- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes in urine composition | NTIS** OTS0522820 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2.5 mg(F)/m3 | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Suspected human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 63,467,1995 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 97,469,2008 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal No Adequate Data | IMEMDT 39,147,1986 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 39,147,1986 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 63,467,1995 |
| International Agency for Research on Cancer (IARC) | Cancer Review: Group 2A | IMEMDT 97,469,2008 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 97,469,2008 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMSUDL 7,56,1987 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2A | IMEMDT 97,469,2008 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2A | IMEMDT 63,467,1995 |
| TOXICOLOGY REVIEW | FCTOD7 44,1699,2006 | |
| TOXICOLOGY REVIEW | FCTOD7 49,1877,2011 |
Standards and Regulations
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL FLUORIDE-air | use 29 Code of Federal Regulations (CFR) 1910.1017 | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULE | FEREAC 47,27009,82 |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health