Urea, 1-(1-naphthyl)-2-thio-

RTECS #

YT9275000

CAS #

86-88-4
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

202.29

Molecular Formula

C₁₁H₁₀N₂S

Synonyms

1-(1-Naphthyl)-2-thiourea
1-Naftil-tiourea (Italian)
1-Naftylthioureum (Dutch)
1-Naphthalenylthiourea
1-Naphthyl thiourea
1-Naphthyl-thioharnstoff (German)
1-Naphthyl-thiouree (French)
alpha-Naftylthiomocovina (Czech)
alpha-Naphthalthioharnstoff (German)
alpha-Naphthothiourea
Alphanaphthyl thiourea
alpha-Naphthylthiocarbamide
alpha-Naphthylthiourea
alpha-Naphthylthiourea (DOT:OSHA)
Alphanaphtyl thiouree (French)
Alrato
ANTU
ANTU (ACGIH:OSHA)
Anturat
Bantu
Chemical 109
Dirax
Kill kantz
Krysid
Krysid PI
N-(1-Naphthyl)-2-thiourea
Naphtox
Rattrack
Rat-TU
RCRA waste number P072
Smeesana
Thiourea, 1-naphthalenyl-
U-5227
USAF EK-P-5976

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
morphological transform	embryo/hamster	1600 µg/L	NCIMAV 58,243,1981
mutation in microorganisms	/Salmonella typhimurium	500 nmol/L (-enzymatic activation step)	ENMUDM 3,11,1981

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
subcutaneous/mouse	lowest published toxic dose: 5 mg/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Blood: Tumors	NTIS** PB223-159

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/chicken	lethal dose (50 percent kill): 2500 mg/kg		PSEBAA 62,22,1946
intraperitoneal/Dog	lethal dose (50 percent kill): 16 mg/kg		ENTOX* -,188,2005
intraperitoneal/guinea pig	lethal dose (50 percent kill): 350 mg/kg		PSEBAA 62,22,1946
intraperitoneal/monkey	lethal dose (50 percent kill): 175 mg/kg		PSEBAA 62,22,1946
intraperitoneal/mouse	lethal dose (50 percent kill): 10 mg/kg		NTIS** AD277-689
intraperitoneal/rat	lethal dose (50 percent kill): 2470 µg/kg	Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Pleural effusion	JPETAB 97,432,1949
oral/cat	lethal dose (50 percent kill): 500 mg/kg		PSEBAA 62,22,1946
oral/chicken	lethal dose (50 percent kill): 4250 mg/kg		PSEBAA 62,22,1946
oral/Dog	lethal dose (50 percent kill): 380 µg/kg		ENTOX* -,188,2005
oral/monkey	lethal dose (50 percent kill): 4250 mg/kg		85DPAN -,-,1971/1976
oral/mouse	lethal dose (50 percent kill): 5 mg/kg		YKYUA6 28,329,1977
oral/pig	lowest published lethal dose: 50 mg/kg		YKYUA6 28,329,1977
oral/rat	lethal dose (50 percent kill): 6 mg/kg		AFDOAQ 16,47,1952
unreported route/chicken	lethal dose (50 percent kill): 700 mg/kg		30ZDA9 -,238,1971
unreported route/man	lowest published lethal dose: 588 mg/kg		85DCAI 2,73,1970
unreported route/monkey	lethal dose (50 percent kill): >2 gm/kg		BCFAAI 97,289,1958
unreported route/rabbit	lethal dose (50 percent kill): >200 mg/kg		BCFAAI 97,289,1958

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.3 mg/m³ (skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 30,347,1983
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 30,347,1983
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMSUDL 7,263,1987
TOXICOLOGY REVIEW		ADCSAJ 13,271,1970
TOXICOLOGY REVIEW		ENTOX* -,188,2005

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.3 mg/m³	DTLVS* 3,14,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.3 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.3 mg/m³;KZW 1.5 mg/m³, inhal, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.3 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.3 mg/m³, carc, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.3 mg/m³, short term exposure limit 0.9 mg/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.3 mg/m³, C3 Carcinogen, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.3 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.3 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.3 mg/m³;short term exposure limit 0.9 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.3 mg/m³, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0.3 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.3 mg/m³, KZG-week 0.6 mg/m³, carc 3, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.3 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.3 mg/m³, JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.3 mg/m³, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.3 mg/m³	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.3 mg/m³	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.3 mg/m³	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.3 mg/m³	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ANTU-air	10H time-weighted average 0.3 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code M0294; Number of Industries 1; Total Number of Facilities 25; Number of Occupations 4; Total Number of Employees Exposed 1450

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health