s-Triazole, 3-amino-

RTECS #

XZ3850000

CAS #

61-82-5; 155-25-9
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

84.10

Molecular Formula

C₂H₄N₄

Synonyms

1H-1,2,4-Triazol-3-amine
3,A-T
3-Amino-1,2,4-triazole
3-Amino-1,2,4-triazole (ACGIH)
3-Amino-1H-1,2,4-triazole
3-Amino-s-triazole
3-Aminotriazole
Amino triazole weedkiller 90
Aminotriazole (plant regulator)
Aminotriazol-spritzpulver
Amitol
Amitrol
Amitrol 90
Amitrole
Amitrole (ACGIH)
Amitrol-T
Amizol
AT
ATA
Campaprim A 1544
Cytrol
Cytrole
Diurol
Diurol 5030
Elmasil
Emisol
Emisol 50
Emisol F
ENT 25445
Herbidal total
Herbizole
Kleer-lot
Orga-414
Radoxone TL
Ramizol
RCRA waste number U011
Simazol
Solution concentree T271
Triazolamine
USAF XR-22
Vorox
Vorox AA
Vorox AS
Weedar ADS
Weedar AT
Weedazin
Weedazin arginit
Weedazol
Weedex granulat
X-All liquid

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA adduct	/Escherichia coli	10 µmol/L	MUREAV 89,95,1981
DNA Damage	/Bacillus subtilis	1 mg/disc	PMRSDJ 1,175,1981
DNA Damage	liver/human	0.1 mmol/l/48H	MUREAV 696,21,2010
DNA inhibition	fibroblast/human	100 mmol/L	MUREAV 183,89,1987
DNA repair	/Saccharomyes cerevisiae	100 mg/L	PMRSDJ 1,502,1981
gene conversion and mitotic recombination	/Saccharomyes cerevisiae	300 mg/L	PMRSDJ 1,491,1981
gene conversion and mitotic recombination	/Aspergillus nidulans	600 µg/L	MUREAV 147,288,1985
host-mediated assay	Salmonella typhimurium/mouse	12 mg/kg	JJIND8 62,911,1979
morphological transform	embryo/hamster	10 mg/L	TOLED5 7,211,1981
morphological transform	kidney/hamster	250 mg/L	PMRSDJ 1,638,1981
morphological transform	embryo/rat	80 mg/L	JJIND8 67,1303,1981
morphological transform	embryo/mouse	125 mg/L	EMMUEG 12,21,1988
morphological transform	fibroblast/mouse	0.01 mg/L/21D (-enzymatic activation step)	EMMUEG 35,300,2000
mutation in mammalian somatic cells	embryo/hamster	1 mg/L	MUREAV 140,205,1984
mutation in microorganisms	/Other microorganisms	1 mg/plate (-enzymatic activation step)	MUREAV 57,277,1978
mutation in microorganisms	/Salmonella typhimurium	50 µg/plate (-enzymatic activation step)	PMRSDJ 1,351,1981
mutation in microorganisms	/Escherichia coli	50 µg/plate (+enzymatic activation step)	PMRSDJ 1,351,1981
mutation in microorganisms	/Saccharomyes cerevisiae	840 mg/L/16H	MUTAEX 20,105,2004
phage inhibition capacity	/Escherichia coli	15 gm/L	VIRLAX 99,257,1979
sex chromosome loss and nondisjunction	/Saccharomyes cerevisiae	50 mg/L	PMRSDJ 1,468,1981
sex chromosome loss and nondisjunction	/Aspergillus nidulans	600 µg/L	MUREAV 147,288,1985
specific locus test	oral/Drosophila melanogaster	500 µmol/L	MUREAV 242,169,1990

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	700 µg/kg (22D pregnant)	Reproductive: Specific developmental abnormalities: Endocrine system	ANREAK 145,284,1963
oral/mouse	2600 mg/kg (6-18D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	ARTODN 33,41,1974
oral/mouse	1935 mg/kg (6-14D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death	NTIS** PB223-160
subcutaneous/mouse	4176 mg/kg (6-14D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death	NTIS** PB223-160

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 113 gm/kg/3W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	JNCIAM 42,1101,1969
oral/mouse	toxic dose: 366 gm/kg/26W- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors	TOLED5 29,145,1985
oral/mouse	lowest published toxic dose: 21.6 gm/kg/180D- intermittent	Tumorigenic: Neoplastic by RTECS criteria Endocrine: Thyroid tumors Tumorigenic: Increased incidence of tumors in susceptible strains	CRNGDP 30,1614,2009
oral/rat	lowest published toxic dose: 4595 mg/kg/2.5Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Endocrine: Tumors Endocrine: Thyroid tumors	TXAPA9 69,161,1983
oral/rat	toxic dose: 3670 mg/kg/2Y- continuous	Tumorigenic: Neoplastic by RTECS criteria Endocrine: Thyroid tumors	SCIEAS 132,296,1960
oral/rat	toxic dose: 122 gm/kg/70W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Endocrine: Thyroid tumors	JNCIAM 57,861,1976
oral/rat	toxic dose: 105 gm/kg/60W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Endocrine: Thyroid tumors	NMJOAA 23,83,1978

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/mouse	lethal dose (50 percent kill): 200 mg/kg		NTIS** AD277-689
intravenous/mouse	lethal dose (50 percent kill): >5 gm/kg		OYYAA2 13,597,1977
oral/mouse	lethal dose (50 percent kill): 14700 mg/kg		PCOC** -,33,1966
oral/quail	lethal dose (50 percent kill): >316 mg/kg		EESADV 6,149,1982
oral/rat	lethal dose (50 percent kill): 1100 mg/kg		RREVAH 10,97,1965
skin/rat	lethal dose (50 percent kill): >10 gm/kg		WRPCA2 9,119,1970
Tank with water/Zebrafish	the toxic concentration that affects 50% of the population of interest): 2080.2 µmol/L/3D	Endocrine: Evidence of thyroid hypofunction	TXAPA9 269,169,2013
Tank with water/Zebrafish	the toxic concentration that affects 10% of the population of interest): 561.9 µmol/L/3D	Endocrine: Evidence of thyroid hypofunction	TXAPA9 269,169,2013

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/hamster	lowest published toxic dose: 4704 mg/kg/28W- continuous	Endocrine: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	ARTODN 60,343,1987
oral/mouse	lowest published toxic dose: 14070 mg/kg/3W- continuous	Blood: Changes in other cell count (unspecified)	NSAPCC 375(Suppl 1),30,2007
oral/rat	lowest published toxic dose: 700 mg/kg/28D- intermittent	Endocrine: Changes in thyroid weight	ARTODN 83,459,2009
oral/rat	lowest published toxic dose: 3500 mg/kg/28D- intermittent	Endocrine: Evidence of thyroid hypofunction Endocrine: Changes in pituitary weight Endocrine: Changes in thyroid weight	ARTODN 83,459,2009
oral/rat	lowest published toxic dose: 313 mg/kg/90D- continuous	Endocrine: Thyroid weight (goiter)	JEPTDQ 1(1),147,1977
oral/rat	lowest published toxic dose: 300 mg/kg/3D- continuous	Endocrine: Other changes	JOENAK 94,131,1982
oral/rat	lowest published toxic dose: 700 mg/kg/7D- continuous	Endocrine: Thyroid weight (goiter)	JOENAK 94,131,1982
oral/rat	lowest published toxic dose: 26250 mg/kg/30W- continuous	Endocrine: Thyroid weight (goiter)	JJIND8 57,861,1976
oral/rat	lowest published toxic dose: 61250 mg/kg/70W- continuous	Endocrine: Tumors	JJIND8 57,861,1976
oral/rat	lowest published toxic dose: 420 mg/kg/14D- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXAPA9 60,45,1981
oral/rat	lowest published toxic dose: 168 mg/kg/4W- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JTSCDR 30,1,2005
oral/rat	lowest published toxic dose: 252 mg/kg/6W- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Endocrine: Changes in thyroid weight	JTSCDR 30,1,2005

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.2 mg/m³	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed animal carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 7,31,1974
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 79,-,2000
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 7,31,1974
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 79,-,2000
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 79,-,2000
TOXICOLOGY REVIEW		DTTIAF 80,485,1973
TOXICOLOGY REVIEW		85CVA2 5,250,1970
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		JTEHD6 7,1,2004
TOXICOLOGY REVIEW		MUREAV 653,23,2008
TOXICOLOGY REVIEW		REPTED 25,304,2007
TOXICOLOGY REVIEW		HUTOX* -,551,1996
TOXICOLOGY REVIEW		MUREAV 672,10,2009
TOXICOLOGY REVIEW		HTOPA* 1,501,2002
TOXICOLOGY REVIEW		IMEMDT 79,381,
TOXICOLOGY REVIEW		NBREV* 5,1,1981
TOXICOLOGY REVIEW		MUREAV 653,99,2008
TOXICOLOGY REVIEW		REPTED 33,188,2012
TOXICOLOGY REVIEW		TOLED5 202,36,2011
TOXICOLOGY REVIEW		MUREAV 786-788,14,2015
TOXICOLOGY REVIEW		MUREAV 795,7,2016
TOXICOLOGY REVIEW		RTOPDW 61,251,2011

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	RED Completed	RBREV* -,85,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.2 mg/m³, short term exposure limit 3 ppm, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.2 mg/m³, inhal, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.2 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.2 mg/m³, carc, MAY2011
Occupational Exposure Limit-FRANCE	VME 0.06 ppm (0.2 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.2 mg/m³, inhal, 2011
Occupational Exposure Limit-ICELAND	time-weighted average 0.2 mg/m³, NOV2011
Occupational Exposure Limit-JAPAN	2B carc, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 0.2 mg/m³, 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.2 mg/m³, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0.2 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.2 mg/m³, carc 3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.2 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO AMITROLE-air	8H Carcinogen time-weighted average 0.2 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 84718; Number of Industries 3; Total Number of Facilities 8; Number of Occupations 4; Total Number of Employees Exposed 693; Total Number of Female Employees Exposed 24

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-nondisjunction; N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; E coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo; Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health