Toluene, m-nitro-
RTECS #
XT2975000
CAS #
Updated
March 2019
Molecular Weight
137.15
Molecular Formula
C7H7NO2
Synonyms
1-Methyl-3-nitrobenzene
3-Methylnitrobenzene
3-Nitrotoluene
3-Nitrotoluol
Benzene, 1-methyl-3-nitro- (9CI)
meta-Nitrotoluol
m-Methylnitrobenzene
m-Nitrotoluene
m-Nitrotoluene (ACGIH:OSHA)
MNT
Nitrotoluene, meto-
3-Methylnitrobenzene
3-Nitrotoluene
3-Nitrotoluol
Benzene, 1-methyl-3-nitro- (9CI)
meta-Nitrotoluol
m-Methylnitrobenzene
m-Nitrotoluene
m-Nitrotoluene (ACGIH:OSHA)
MNT
Nitrotoluene, meto-
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin /rabbit | 580 mg/24H | mild | HPV285 -,-,2001 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| micronucleus test | lung/hamster | 2500 µmol/L/6H (+enzymatic activation step) | MUTAEX 26,709,2011 |
| micronucleus test | lung/hamster | 5000 µmol/L/48H (-enzymatic activation step) | MUTAEX 26,709,2011 |
| sister chromatid exchange | ovary/hamster | 115 mg/L | EMMUEG 10(Suppl 10),1,1987 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 31122 mg/kg (13W prior to copulation) | Reproductive: Maternal effects: Menstrual cycle changes or disorders | NTPTR* NIH-93-3346 |
| oral/rat | 60151 mg/kg (13W male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | NTPTR* NIH-93-3346 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lethal concentration (50 percent kill): 425 mg/m3 | Brain and Coverings: Recordings from specific areas of CNS Liver: Fatty liver degeneration Blood: Methemoglobinemia- Carboxhemoglobinemia | GTPZAB 22(7),52,1978 |
| inhalation/mouse | lethal concentration (50 percent kill): >157 ppm/4H | HPV285 -,-,2001 | |
| inhalation/mouse | lethal concentration (50 percent kill): >2417 mg/m3/1H | HPV285 -,-,2001 | |
| inhalation/rat | lethal concentration (50 percent kill): >157 ppm/4H | HPV285 -,-,2001 | |
| inhalation/rat | lethal concentration (50 percent kill): >2417 mg/m3/1H | HPV285 -,-,2001 | |
| inhalation/rat | lethal concentration (50 percent kill): 693 mg/m3 | Brain and Coverings: Recordings from specific areas of CNS Liver: Fatty liver degeneration Blood: Methemoglobinemia- Carboxhemoglobinemia | GTPZAB 22(7),52,1978 |
| oral/guinea pig | lethal dose (50 percent kill): 3600 mg/kg | CHABA8 73,91015e,1970 | |
| oral/mouse | lethal dose (50 percent kill): 330 mg/kg | CHABA8 73,91015e,1970 | |
| oral/rabbit | lethal dose (50 percent kill): 1750 mg/kg | Brain and Coverings: Recordings from specific areas of CNS Liver: Fatty liver degeneration Blood: Methemoglobinemia- Carboxhemoglobinemia | GTPZAB 22(7),52,1978 |
| oral/rat | lethal dose (50 percent kill): 1070 mg/kg | HPV285 -,-,2001 | |
| skin/rabbit | lethal dose (50 percent kill): >20000 mg/kg | HPV285 -,-,2001 | |
| skin/rat | lethal dose (50 percent kill): >1157 mg/kg | HPV285 -,-,2001 | |
| unreported route/guinea pig | lethal dose (50 percent kill): 3600 mg/kg | HPV285 -,-,2001 | |
| unreported route/mouse | lethal dose (50 percent kill): 330 mg/kg | HPV285 -,-,2001 | |
| unreported route/rabbit | lethal dose (50 percent kill): 1750 mg/kg | HPV285 -,-,2001 | |
| unreported route/rat | lethal dose (50 percent kill): 1590 mg/kg | HPV285 -,-,2001 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 30 mg/m3/4H/17W- intermittent | Kidney, Ureter, and Bladder: Proteinuria Kidney, Ureter, and Bladder: Other changes in urine composition | GTPZAB 22(7),52,1978 |
| oral/mouse | lowest published toxic dose: 9191 mg/kg/13W- intermittent | Liver: Changes in liver weight | HPV285 -,-,2001 |
| oral/mouse | lowest published toxic dose: 68250 mg/kg/13W- intermittent | Behavioral: Food intake (animal) Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV285 -,-,2001 |
| oral/mouse | lowest published toxic dose: 136500 mg/kg/13W- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV285 -,-,2001 |
| oral/mouse | lowest published toxic dose: 67613 mg/kg/13W- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Related to Chronic Data: Changes in testicular weight | NTPTR* NIH-93-3346 |
| oral/mouse | lowest published toxic dose: 5600 mg/kg/14D- intermittent | Endocrine: Changes in thymus weight Blood: Changes in other cell count (unspecified) | DCTODJ 17,359,1994 |
| oral/rat | lowest published toxic dose: 31122 mg/kg/13W- continuous | Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in platelet count Related to Chronic Data: Changes in testicular weight | NTPTR* NIH-93-3346 |
| oral/rat | lowest published toxic dose: 10000 mg/kg/4W- intermittent | Lung, Thorax, or Respiration: Dyspnea | HPV285 -,-,2001 |
| oral/rat | lowest published toxic dose: 20000 mg/kg/4W- intermittent | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV285 -,-,2001 |
| oral/rat | lowest published toxic dose: 36000 mg/kg/24W- intermittent | Blood: Other changes Skin and Appendages: Other: Hair | HPV285 -,-,2001 |
| oral/rat | lowest published toxic dose: 4277 mg/kg/13W- intermittent | Kidney, Ureter, and Bladder: Changes primarily in glomeruli Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | HPV285 -,-,2001 |
| oral/rat | lowest published toxic dose: 17108 mg/kg/13W- intermittent | Kidney, Ureter, and Bladder: Changes primarily in glomeruli Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | HPV285 -,-,2001 |
| oral/rat | lowest published toxic dose: 68250 mg/kg/13W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes primarily in glomeruli Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | HPV285 -,-,2001 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2 ppm (skin) | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 65,409,1996 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 65,409,1996 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 65,409,1996 |
| TOXICOLOGY REVIEW | MUTAEX 23,271,2008 | |
| TOXICOLOGY REVIEW | RTOPDW 60,120,2011 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 2 ppm (11 mg/m3), JUL2008 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 2 ppm (11 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 2 ppm (12 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-FRANCE | VME 2 ppm (11 mg/m3), Skin, FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 2 ppm (12 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 5 ppm (30 mg/m3);short term exposure limit 10 ppm (60 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 2 ppm (11 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 1 ppm (5.5 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 2 ppm (11 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 3 mg/m3, MAC(short term exposure limit) 9 mg/m3, JAN1999 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 1 ppm (6 mg/m3);short term exposure limit 2 ppm (11 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 2 ppm (11 mg/m3), KZG-week 4 ppm (22 mg/m3), skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 6 mg/m3, Skin, 2003 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 ppm (30 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 5 ppm (30 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 ppm (30 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 ppm (30 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO m-NITROTOLUENE-air | 10H time-weighted average 2 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health