Toluene, o-chloro-

RTECS #

XS9000000

CAS #

95-49-8
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

126.59

Molecular Formula

C₇H₇Cl

Synonyms

1-Chloro-2-methylbenzene
1-Methyl-2-chlorobenzene
2-Chloro-1-methylbenzene
2-Chlorotoluene
2-Methylchlorobenzene
Benzene, 1-chloro-2-methyl- (9CI)
Halso 99
o-Chlorotoluene
o-Chlorotoluene (ACGIH)
o-Tolyl chloride

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	50 µL	moderate	NTIS** OTS0572387

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	Lowest published lethal concentration: 4400 ppm	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory stimulation	85INA8 6,308,1991
inhalation/mouse	Lowest published lethal concentration: 4400 ppm	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory stimulation	85INA8 6,308,1991
inhalation/rat	Lowest published lethal concentration: 4400 ppm	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory stimulation	85INA8 6,308,1991
inhalation/rat	lethal concentration (50 percent kill): 7119 mg/kg/4H		HPV080 -,-,2001
oral/cat	Lethal dose: >500 mg/kg		HPV080 -,-,2001
oral/Dog	Lethal dose: >1083 mg/kg		HPV080 -,-,2001
oral/duck	Lethal dose: >5410 mg/kg		HPV080 -,-,2001
oral/mouse	lethal dose (50 percent kill): 2500 mg/kg	Eye: Other eye effects Behavioral: Tremor Behavioral: Excitement	GTPZAB 25(10),56,1981
oral/mouse	lethal dose (50 percent kill): 3776 mg/kg		HPV080 -,-,2001
oral/rat	lethal dose (50 percent kill): 3900 mg/kg	Eye: Other eye effects Behavioral: Tremor Behavioral: Excitement	GTPZAB 25(10),56,1981
oral/rat	lethal dose (50 percent kill): 2100 mg/kg	Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Gastritis	HPV080 -,-,2001
oral/rat	lethal dose (50 percent kill): 1659 mg/kg		HPV080 -,-,2001
oral/wild bird	Lethal dose: >5410 mg/kg		HPV080 -,-,2001
skin/rabbit	Lethal dose: >2165 mg/kg		HPV080 -,-,2001
unreported route/guinea pig	lethal dose (50 percent kill): 3 gm/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Lung, Thorax, or Respiration: Respiratory depression	GISAAA 46(2),67,1981
unreported route/mouse	lethal dose (50 percent kill): 4400 mg/kg		GISAAA 45(12),64,1980
unreported route/rat	lethal dose (50 percent kill): 5700 mg/kg		GISAAA 45(12),64,1980

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rabbit	lowest published toxic concentration: 16 gm/m³/6H/23D- intermittent	Behavioral: Food intake (animal) Kidney, Ureter, and Bladder: Urine volume increased Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0537026
inhalation/rat	lowest published toxic concentration: 11400 mg/m³/6H/14D- intermittent	Behavioral: Food intake (animal) Behavioral: Ataxia Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0537026
oral/rat	lowest published toxic dose: 35910 mg/kg/9W- intermittent	Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Renal function tests depressed Blood: Other changes	GISAAA 46(2),67,1981

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 50 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		RTOPDW 55,43,2009

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 50 ppm (259 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 50 ppm (250 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 50 ppm (263 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 50 ppm (285 mg/m³), skin, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 50 ppm (260 mg/m³), short term exposure limit 75 ppm (390 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 50 ppm (250 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 50 ppm (285 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 50 ppm (250 mg/m³), short term exposure limit 75 ppm (375 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 50 ppm (250 mg/m³);short term exposure limit 75 ppm (375 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 50 ppm (259 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 25 ppm (125 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 50 ppm (259 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 10 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 50 ppm (250 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 250 mg/m³, Skin, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-CHLOROTOLUENE-air	10H time-weighted average 50 ppm;short term exposure limit 75 ppm	NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983	Hazard Code X1254; Number of Industries 2; Total Number of Facilities 62; Number of Occupations 8; Total Number of Employees Exposed 11617; Total Number of Female Employees Exposed 963

Status in Federal Agencies

Organization	Reference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health