Stannane, tricyclohexylhydroxy-
RTECS #
WH8750000
CAS #
Updated
September 2013
Molecular Weight
385.21
Molecular Formula
C18H34OSn
Synonyms
Cyhexatin
Cyhexatin (ACGIH)
Dowco-213
ENT 27,395-X
ENT 27395
M 3180
Plictran
Plictran 50W
Plyctran
TCTH
Tin, tricyclohexylhydroxy-
Tricyclohexylhydroxystannane
Tricyclohexylhydroxytin
Tricyclohexylstannanol
Tricyclohexylstannium hydroxide
Tricyclohexyltin hydroxide
Tricyclohexylzinnhydroxid (German)
Cyhexatin (ACGIH)
Dowco-213
ENT 27,395-X
ENT 27395
M 3180
Plictran
Plictran 50W
Plyctran
TCTH
Tin, tricyclohexylhydroxy-
Tricyclohexylhydroxystannane
Tricyclohexylhydroxytin
Tricyclohexylstannanol
Tricyclohexylstannium hydroxide
Tricyclohexyltin hydroxide
Tricyclohexylzinnhydroxid (German)
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
sister chromatid exchange | lymphocyte/human | 25 mg/L | MUREAV 321,219,1994 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | 108 mg/kg (multigenerations) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | EQSFAP 4,80,1975 |
oral/rabbit | 23.25 mg/kg (1-31D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | HBPTO* 2,1217,2001 |
skin/rabbit | 3 mg/kg (6-18D pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | HBPTO* 2,1217,2001 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lethal concentration (50 percent kill): 290 mg/m3 | GTPZAB 28(5),52,1984 | |
inhalation/rat | lethal concentration (50 percent kill): 244 mg/m3 | GISAAA 49(2),74,1984 | |
intraperitoneal/rat | lethal dose (50 percent kill): 13 mg/kg | DOWCC* | |
oral/cat | lethal dose (50 percent kill): >800 mg/kg | Gastrointestinal: Nausea or vomiting | EQSFAP 4,80,1975 |
oral/chicken | lethal dose (50 percent kill): 654 mg/kg | HBPTO* 2,1216,2001 | |
oral/Dog | lethal dose (50 percent kill): >800 mg/kg | Gastrointestinal: Nausea or vomiting | EQSFAP 4,80,1975 |
oral/domestic animal | lowest published lethal dose: 150 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) Behavioral: Fluid intake | TXAPA9 31,66,1975 |
oral/guinea pig | lethal dose (50 percent kill): 780 mg/kg | HBPTO* 2,1216,2001 | |
oral/monkey | lethal dose (50 percent kill): >800 mg/kg | Gastrointestinal: Nausea or vomiting | EQSFAP 4,80,1975 |
oral/mouse | lethal dose (50 percent kill): 275 mg/kg | Brain and Coverings: Recordings from specific areas of CNS Peripheral Nerve and Sensation: Recording from peripheral motor nerve | GISAAA 47(7),80,1982 |
oral/quail | lethal dose (50 percent kill): 255 mg/kg | EQSFAP 4,80,1975 | |
oral/rabbit | lethal dose (50 percent kill): 458 mg/kg | Brain and Coverings: Recordings from specific areas of CNS Peripheral Nerve and Sensation: Recording from peripheral motor nerve | GISAAA 47(7),80,1982 |
oral/rat | lethal dose (50 percent kill): 180 mg/kg | KSKZAN 16(2),59,1978 | |
oral/rat | lowest published toxic dose: 50 mg/kg | Behavioral: Food intake (animal) Gastrointestinal: Hypermotility, diarrhea | HBPTO* 2,1216,2001 |
skin/human | lowest published toxic dose: 11 µg/kg/1D | Nutritional and Gross Metabolic: Changes in: Other metals | HBPTO* 2,1218,2001 |
skin/rabbit | lethal dose (50 percent kill): 2422 mg/kg | Brain and Coverings: Recordings from specific areas of CNS Peripheral Nerve and Sensation: Recording from peripheral motor nerve | GISAAA 47(7),80,1982 |
skin/rat | lethal dose (50 percent kill): 446 mg/kg | FAATDF 7,299,1986 | |
subcutaneous/mammal (species unspecified) | lowest published toxic dose: 30 mg/kg | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | HBTME* -,839,2007 |
unreported route/mouse | lethal dose (50 percent kill): 780 mg/kg | TGANAK 16(1),45,1982 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/Dog | lowest published toxic dose: 270 mg/kg/90D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | EQSFAP 4,80,1975 |
oral/mammal (species unspecified) | lowest published toxic dose: 2310 mg/kg/44W- intermittent | Brain and Coverings: Recordings from specific areas of CNS Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | GISAAA 47(7),80,1982 |
oral/mouse | lowest published toxic dose: 1201 mg/kg/4D- continuous | Endocrine: Changes in spleen weight Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | PCBPBS 6,270,1976 |
oral/mouse | lowest published toxic dose: 8640 mg/kg/90D- continuous | Behavioral: Muscle weakness Gastrointestinal: Hypermotility, diarrhea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | EQSFAP 4,80,1975 |
oral/rat | lowest published toxic dose: 180 mg/kg/3D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | GISAAA 49(2),74,1984 |
oral/rat | lowest published toxic dose: 2700 mg/kg/90D- continuous | Behavioral: Muscle weakness Gastrointestinal: Hypermotility, diarrhea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | EQSFAP 4,80,1975 |
oral/rat | lowest published toxic dose: 2190 mg/kg/2Y- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HBPTO* 2,1217,2001 |
oral/rat | lowest published toxic dose: 730 mg/kg/2Y- continuous | Liver: Other changes | HBPTO* 2,1217,2001 |
oral/rat | lowest published toxic dose: 4380 mg/kg/2Y- continuous | Spinal Cord: Other degenerative changes | HBPTO* 2,1217,2001 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 mg(Sn)/m3 | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 mg/m3 | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-short term exposure limit 0.2 mg(Sn)/m3 (skin) | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | EQSFAP 4,80,1975 | |
TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
TOXICOLOGY REVIEW | HUTOX* -,561,1996 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,106,1998 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, JUL2008 | |
Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 mg/m3, JUL2008 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, Skin, MAR2002 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 5 mg/m3, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 5 mg/m3, MAY2011 | |
Occupational Exposure Limit-FRANCE | VME 5 mg/m3, FEB2006 | |
Occupational Exposure Limit-HUNGARY | time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.4 mg(Sn)/m3, Skin, SEP2000 | |
Occupational Exposure Limit-ICELAND | time-weighted average 5 mg/m3, NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 5 mg/m3, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 5 mg/m3, 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 mg/m3, JAN2002 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, skin, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 0.1 mg(Sn)/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 0.02 mg/m3, Skin, JUN2003 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.1 mg(Sn)/m3, KZG-week 0.2 mg(Sn)/m3, inhal, skin, JAN2011 | |
Occupational Exposure Limit-THAILAND | time-weighted average 0.1 mg(Sn)/m3, JAN1993 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 5 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.1 mg(Sn)/m3, JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.1 mg(Sn)/m3 | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.1 mg(Sn)/m3 | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.1 mg(Sn)/m3 | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.1 mg(Sn)/m3 | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYHEXATIN-air | 10H time-weighted average 5 mg/m3 | NIOSH* DHHS #92-100,1992 |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ORGANOTIN COMPOUND-air | 10H time-weighted average 0.1 mg(Sn)/m3 | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH Analytical Method, 1994: Organotin compounds as Sn, 5504 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health