Silver

RTECS #

VW3500000

CAS #

7440-22-4
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

107.87

Molecular Formula

Synonyms

Argentum
C.I. 77820
L-3
Shell silver
Silber (German)
Silver (ACGIH:OSHA)
Silver atom

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
implant/mouse	lowest published toxic dose: 11 gm/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Tumorigenic: Tumors at site of application	NATWAY 42,75,1955
implant/rat	toxic dose: 2570 mg/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Tumorigenic: Tumors at site of application	NATWAY 42,75,1955
implant/rat	lowest published toxic dose: 2400 mg/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Tumorigenic: Tumors at site of application	CNREA8 16,439,1956
multiple/rat	lowest published toxic dose: 330 mg/kg/43W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Tumorigenic: Tumors at site of application	ZEKBAI 63,586,1960

Acute Toxicity Data and References

Route/Organism	Dose	Reference
oral/guinea pig	Lethal dose: >5 gm/kg	GTPZAB 27(12),33,1983
oral/mouse	lethal dose (50 percent kill): 100 mg/kg	ENTOX* ,17,2005
oral/mouse	Lethal dose: >10 gm/kg	GTPZAB 27(12),33,1983

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 8400 mg/kg/28D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	TOXID9 -,90,2008
oral/rat	lowest published toxic dose: 8400 mg/kg/28D- intermittent	Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	TOXID9 -,90,2008

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 mg/m³	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		FOREAE 7,313,1942
TOXICOLOGY REVIEW		MIBUBI 9,321,1975
TOXICOLOGY REVIEW		PTPAD4 1,127,1976
TOXICOLOGY REVIEW		AJMEAZ 38,409,1965
TOXICOLOGY REVIEW		PEXTAR 12,102,1969
TOXICOLOGY REVIEW		CRTXB2 37,237,2007
TOXICOLOGY REVIEW		ENTOX* -,17,2005
TOXICOLOGY REVIEW		TOPADD 32(Suppl. 2),71,2004
TOXICOLOGY REVIEW		HBTME* ,809,2007
TOXICOLOGY REVIEW		HUTOX* -,515,1996

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	RED Completed	RBREV* -,335,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.01 mg/m³	DTLVS* 3,231,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.1 mg/m³;KZW 0.1 mg/m³, inhal, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.01 mg/m³ (dust), MAY2011
Occupational Exposure Limit-EC	time-weighted average 0.1 mg/m³, JUN2000
Occupational Exposure Limit-FINLAND	time-weighted average 0.1 mg/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.1 mg/m³, FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.1 mg/m³, inhal, 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 0.1 mg/m³, short term exposure limit 0.4 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.01 mg/m³, dust, NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.01 mg/m³, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 0.1 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.1 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.1 mg/m³, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.01 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,1 mg/m³, JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 1 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 0.1 mg/m³, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.1 mg/m³, KZG-week 0.8 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.1 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 0.1 mg/m³, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.01 mg(Ag)/m³	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.01 mg(Ag)/m³	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.01 mg(Ag)/m³	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.01 mg(Ag)/m³	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SILVER, metal and soluble compds-air	10H time-weighted average 0.01 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code M1804; Number of Industries 4; Total Number of Facilities 156; Number of Occupations 9; Total Number of Employees Exposed 3937; Total Number of Female Employees Exposed 2435
National Occupational Exposure Survey 1983	Hazard Code 68730; Number of Industries 118; Total Number of Facilities 13582; Number of Occupations 76; Total Number of Employees Exposed 204921; Total Number of Female Employees Exposed 37439
National Occupational Hazard Survey 1974	Hazard Code 68730; Number of Industries 53; Total Number of Facilities 2163; Number of Occupations 54; Total Number of Employees Exposed 19343

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180430/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
NIOSH Analytical Method, 1994: Metals in urine, 8310
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID121

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health