Pyrophosphoric acid, tetraethyl ester

RTECS #

UX6825000

CAS #

107-49-3
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

290.22

Molecular Formula

C₈H₂₀O₇P₂

Synonyms

Bis-O,O-diethylphosphoric anhydride
Bladan
Diphosphoric acid tetraethyl ester
EA 1285
ENT 18,771
Ethyl pyrophosphate, tetra-
Fosvex
Grisol
HEPT
Hexamite
Killex
Kilmite 40
Lethalaire G-52
Lirohex
Mortopal
Nifos
Nifos T
O,O,O,O-Tetraethyl-difosfaat (Dutch)
O,O,O,O-Tetraetil-pirofosfato (Italian)
Pyrophosphate de tetraethyle (French)
RCRA waste number P111
TEPP (ACGIH:OSHA)
Tetraaethylpyrophosphorsaeureester (German)
Tetraethyl diphosphate
Tetraethyl pyrofosfaat (Dutch)
Tetraethyl pyrophosphate
Tetraethyl pyrophosphate (OSHA)
Tetraethyldifosfat (Czech)
Tetraethylpyrofosfat (Czech)
Tetrastigmine
Tetron
Tetron-100
Vapotone

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
intramuscular/human	lowest published lethal dose: 286 µg/kg	Peripheral Nerve and Sensation: Paresthesia Behavioral: Excitement Gastrointestinal: Nausea or vomiting	CMEP** -,1,1956
intramuscular/man	lowest published lethal dose: 380 µg/kg		JCINAO 37,350,1958
intramuscular/rat	lethal dose (50 percent kill): 1800 µg/kg		JCINAO 37,350,1958
intraperitoneal/mouse	lethal dose (50 percent kill): 830 µg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	AIPTAK 121,104,1959
intraperitoneal/rat	lethal dose (50 percent kill): 650 µg/kg		FEPRA7 6,353,1947
intravenous/mouse	lethal dose (50 percent kill): 200 µg/kg		BJPCAL 9,299,1954
intravenous/pigeon	lethal dose (50 percent kill): 180 µg/kg	Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Eye: Other eye effects	AIPTAK 102,371,1955
intravenous/rabbit	lowest published lethal dose: 300 µg/kg	Behavioral: Convulsions or effect on seizure threshold Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Other changes	BJPCAL 8,466,1953
intravenous/rat	lethal dose (50 percent kill): 300 µg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	CJBPAZ 34,197,1956
oral/duck	lethal dose (50 percent kill): 3560 µg/kg		TXAPA9 47,451,1979
oral/guinea pig	lethal dose (50 percent kill): 2300 µg/kg		JPETAB 105,156,1952
oral/human	lowest published lethal dose: 1429 µg/kg	Peripheral Nerve and Sensation: Paresthesia Behavioral: Excitement Gastrointestinal: Nausea or vomiting	CMEP** -,1,1956
oral/human	lowest published toxic dose: 309 µg/kg	Behavioral: Wakefulness Behavioral: Muscle contraction or spasticity Gastrointestinal: Other changes	CMEP** -,1,1956
oral/man	lowest published lethal dose: 1700 µg/kg		JCINAO 37,350,1958
oral/mouse	lethal dose (50 percent kill): 3 mg/kg		ABCHA6 27,684,1963
oral/rat	lethal dose (50 percent kill): 500 µg/kg		PHJOAV 185,361,1960
oral/wild bird	lethal dose (50 percent kill): 1300 µg/kg		TXAPA9 21,315,1972
parenteral/frog	lethal dose (50 percent kill): 34 mg/kg	Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Altered sleep time (including change in righting reflex) Lung, Thorax, or Respiration: Other changes	AIPTAK 124,212,1960
parenteral/human	lowest published toxic dose: 71 µg/kg	Behavioral: Wakefulness Behavioral: Muscle contraction or spasticity Gastrointestinal: Other changes	CMEP** -,1,1956
skin/duck	lethal dose (50 percent kill): 64 mg/kg		TXAPA9 47,451,1979
skin/mouse	lethal dose (50 percent kill): 8 mg/kg		ABCHA6 27,684,1963
skin/rabbit	lowest published lethal dose: 17 µL/kg	Behavioral: Excitement Gastrointestinal: Changes in structure or function of salivary glands Lung, Thorax, or Respiration: Respiratory stimulation	NTIS** OTS0534856
skin/rat	lethal dose (50 percent kill): 2400 µg/kg		TXAPA9 14,515,1969
subcutaneous/guinea pig	lethal dose (50 percent kill): 700 µg/kg		BJPCAL 14,5,1959
subcutaneous/mouse	lethal dose (50 percent kill): 500 µg/kg		ARZNAD 29,875,1979
subcutaneous/rabbit	lethal dose (50 percent kill): 2 mg/kg		IAEC** 17JUN1974
subcutaneous/rat	lethal dose (50 percent kill): 279 µg/kg		FAATDF 4,S195,1984
unreported route/rabbit	lethal dose (50 percent kill): 1 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	AJOPAA 53,512,1962
unreported route/rat	lethal dose (50 percent kill): 1120 µg/kg		30ZDA9 -,379,1971

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.01 mg/m³ (inhal, vapor, skin)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		CRTXB2 3,289,1975
TOXICOLOGY REVIEW		AQMOAC #73-19,1973
TOXICOLOGY REVIEW		RREVAH 46,1,1973
TOXICOLOGY REVIEW		IRXPAT 3,219,1964
TOXICOLOGY REVIEW		CCATAR 366,1,2006
TOXICOLOGY REVIEW		ENTOX* -,588,2005
TOXICOLOGY REVIEW		CCACL* 21,673,2005

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.004 ppm (0.05 mg/m³)	DTLWS* 3,28,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypt	time-weighted average 0.004 ppm (0.05 mg/m³), Skin, JAN1993
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.004 ppm (0.047 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.005 ppm (0.05 mg/m³);KZW 0.05 ppm (0.5 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.004 ppm (0.048 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.004 ppm (0.05 mg/m³), skin, MAY2011
Occupational Exposure Limit-FRANCE	VME 0.004 ppm (0.05 mg/m³), Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.005 ppm (0.06 mg/m³), skin, 2011
Occupational Exposure Limit-ICELAND	time-weighted average 0.004 ppm (0.05 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.004 ppm (0.05 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.004 ppm (0.05 mg/m³) (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.004 ppm (0.047 mg/m³), skin, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0,004 ppm (0,05 mg/m³), JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.005 ppm (0.05 mg/m³), KZG-week 0.01 ppm (0.1 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.05 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.05 mg/m³, Skin, JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.05 mg/m³, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.05 mg/m³ (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.05 mg/m³ (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.05 mg/m³ (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.05 mg/m³ (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TEPP-air	10H time-weighted average 0.05 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	Hazard Code 71680; Number of Industries 1; Total Number of Facilities 9; Number of Occupations 14; Total Number of Employees Exposed 1434

Status in Federal Agencies

Organization	Reference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Tetraethyl pyrophosphate, 2504
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health