Pyrocatechol
RTECS #
UX1050000
CAS #
Updated
December 2018
Molecular Weight
110.12
Molecular Formula
C6H6O2
Synonyms
1,2-Benzenediol
1,2-Dihydroxybenzene
2-Hydroxyphenol
Benzene, o-dihydroxy-
C.I. 76500
C.I. Oxidation Base 26
Catechin (phenol)
Catechol
Catechol (ACGIH)
Catechol (phenol)
Durafur developer C
Fouramine PCH
Fourrine 68
Katechol (Czech)
NCI-C55856
o-Benzenediol
o-Dihydroxybenzene
o-Dioxybenzene
o-Diphenol
o-Hydroquinone
o-Hydroxyphenol
o-Phenylenediol
Oxyphenic acid
Pelagol Grey C
Phthalhydroquinone
Pyrocatechin
Pyrocatechine
Pyrokatechin (Czech)
1,2-Dihydroxybenzene
2-Hydroxyphenol
Benzene, o-dihydroxy-
C.I. 76500
C.I. Oxidation Base 26
Catechin (phenol)
Catechol
Catechol (ACGIH)
Catechol (phenol)
Durafur developer C
Fouramine PCH
Fourrine 68
Katechol (Czech)
NCI-C55856
o-Benzenediol
o-Dihydroxybenzene
o-Dioxybenzene
o-Diphenol
o-Hydroquinone
o-Hydroxyphenol
o-Phenylenediol
Oxyphenic acid
Pelagol Grey C
Phthalhydroquinone
Pyrocatechin
Pyrocatechine
Pyrokatechin (Czech)
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | embryo/hamster | 3 µmol/L | MUREAV 373,113,1997 |
Cytogenetic Analysis | ovary/hamster | 50 mg/L | CALEDQ 14,251,1981 |
Cytogenetic Analysis | ovary/hamster | 25 µmol/L/4H | MUREAV 661,57,2009 |
Cytogenetic Analysis | lung/hamster | 60 µmol/L/2H | MUREAV 540,29,2003 |
DNA Damage | ovary/hamster | 1 µmol/L/3H | MUREAV 661,57,2009 |
DNA Damage | other cell types/mouse | 0.25 mmol/L/3H | JOETD7 155,599,2014 |
DNA Damage | lymphocyte/human | 100 µmol/L | EMMUEG 26,305,1995 |
DNA Damage | /Other microorganisms | 10 mmol/L | MUREAV 368,235,1996 |
DNA Damage | liver/rat | 3 mmol/L | CALEDQ 63,47,1992 |
DNA Damage | lymphocyte/mouse | 500 µmol/L | MUREAV 203,155,1988 |
DNA inhibition | lymphocyte/mouse | 250 µmol/L | MOPMA3 28,560,1985 |
DNA inhibition | HeLa cell/human | 200 µmol/L | MUREAV 92,427,1982 |
DNA repair | /Bacillus subtilis | 500 mg/L | ESKGA2 32,171,1986 |
gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 300 mg/L | MUREAV 135,109,1984 |
gene conversion and mitotic recombination | /Aspergillus nidulans | 10 mmol/L | MUTAEX 2,235,1987 |
micronucleus test | oral/mouse | 40 mg/kg | MUREAV 208,61,1988 |
micronucleus test | intraperitoneal/mouse | 10 mg/kg | MUREAV 341,29,1994 |
micronucleus test | lung/hamster | 156 µmol/L/6H (+enzymatic activation step) | MUTAEX 26,709,2011 |
micronucleus test | lung/hamster | 78 µmol/L/6H (-enzymatic activation step) | MUTAEX 26,709,2011 |
micronucleus test | lung/hamster | 20 µmol/L/24H (-enzymatic activation step) | MUTAEX 26,709,2011 |
micronucleus test | lung/hamster | 4.7 µmol/L/48H (-enzymatic activation step) | MUTAEX 26,709,2011 |
micronucleus test | ovary/hamster | 22.2 µmol/L/24H (-enzymatic activation step) | MUREAV 751,1,2013 |
micronucleus test | ovary/hamster | 200 µmol/L/3H (+enzymatic activation step) | MUREAV 751,1,2013 |
micronucleus test | fibroblast/hamster | 20 µmol/L/48H | MUREAV 770,37,2014 |
micronucleus test | lung/hamster | 10 µmol/L/12H | MUREAV 808,27,2016 |
micronucleus test | lung/hamster | 25 µmol/L | EVHPAZ 82,81,1989 |
micronucleus test | lung/hamster | 20 µmol/L/6H | MUREAV 808,27,2016 |
micronucleus test | ovary/hamster | 10 µmol/L/4H | MUREAV 661,57,2009 |
morphological transform | other cell types/mouse | 0.25 mg/L/12D | MUREAV 557,191,2004 |
morphological transform | embryo/hamster | 1 µmol/L | MUREAV 373,113,1997 |
mutation in mammalian somatic cells | embryo/hamster | 10 µmol/L | MUREAV 373,113,1997 |
mutation in mammalian somatic cells | lymphocyte/mouse | 2500 µg/L | EMMUEG 11,523,1988 |
mutation in microorganisms | /Salmonella typhimurium | 15 µmol/plate (+enzymatic activation step) | PAACA3 20,117,1979 |
mutation in microorganisms | /Salmonella typhimurium | 4 µg/plate (-enzymatic activation step) | ABCHA6 45,327,1981 |
mutation in microorganisms | /Escherichia coli | 2 mg/plate (-enzymatic activation step) | MUREAV 467,41,2000 |
mutation in microorganisms | /Saccharomyes cerevisiae | 599 mg/L/16H | MUTAEX 20,105,2004 |
other mutation test systems | lymphocyte/human | 40 µmol/L | CNREA8 40,1189,1980 |
other mutation test systems | bone marrow/rabbit | 2 mmol/L | AJIMD8 7,485,1985 |
sex chromosome loss and nondisjunction | embryo/hamster | 30 µmol/L | MUREAV 373,113,1997 |
sister chromatid exchange | lung/hamster | 12500 nmol/L | EVHPAZ 82,81,1989 |
sister chromatid exchange | embryo/hamster | 10 µmol/L | MUREAV 373,113,1997 |
sister chromatid exchange | lymphocyte/human | 40 µmol/L | CNREA8 40,1189,1980 |
Unscheduled DNA Synthesis | oral/rat | 1 gm/kg | JJIND8 74,1283,1985 |
Unscheduled DNA Synthesis | embryo/hamster | 1 µmol/L | MUREAV 373,113,1997 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | 1 gm/kg (11D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | TJADAB 41,43,1990 |
subcutaneous/rat | 5 mg/kg (1D prior to copulation) | Reproductive: Maternal effects: Ovaries, fallopian tubes | ENDOAO 57,466,1955 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/mouse | lowest published toxic dose: 645 gm/kg/96W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | JJCREP 81,207,1990 |
oral/mouse | lowest published toxic dose: 3696 mg/kg/44W- continuous | Tumorigenic: Neoplastic by RTECS criteria Tumorigenic: Facilitates action of known carcinogens Gastrointestinal: Tumors | CALEDQ 139,167,1999 |
oral/rat | lowest published toxic dose: 7854 mg/kg/34W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Gastrointestinal: Tumors | JTPAE7 29,180,2001 |
oral/rat | lowest published toxic dose: 102648 mg/kg/104W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | JTPAE7 29,180,2001 |
oral/rat | lowest published toxic dose: 437 gm/kg/2Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | JJCREP 81,207,1990 |
oral/rat | toxic dose: 60640 mg/kg/24W- continuous | Tumorigenic: Neoplastic by RTECS criteria Gastrointestinal: Tumors | JJCREP 77,854,1986 |
oral/rat | toxic dose: 349 gm/kg/2Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | FCTOD7 33,93,1995 |
oral/rat | lowest published toxic dose: 171 gm/kg/51W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | JJCREP 85,17,1994 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, endothelium | Inhibitor Concentration Low: 10 µmol/L/30M | In Vitro Toxicity Studies: Other assays | PYTOEY 19,245,2012 |
In Vitro/Human, erythrocytes | Inhibitor Concentration Low: 100 mg/L/1H | In Vitro Toxicity Studies: Hemolysis in vitro In Vitro Toxicity Studies: Other assays | FCTOD7 49,2202,2011 |
In Vitro/Human, melanoma | Inhibitor Concentration Low: 100 mg/L/1H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | FCTOD7 50,2123,2012 |
In Vitro/jzx | Inhibitor Concentration Low: 150 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. In Vitro Toxicity Studies: Apoptosis in vitro In Vitro Toxicity Studies: Other assays | TXCYAC 271,107,2010 |
In Vitro/Rat, endocrine tumor | Inhibitor Concentration Low: 5.32 µmol/L | Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | FCTOD7 50,390,2012 |
intraperitoneal/guinea pig | lowest published lethal dose: 150 mg/kg | Behavioral: Ataxia Behavioral: Tetany Lung, Thorax, or Respiration: Dyspnea | VCVGK* -,224,1994 |
intraperitoneal/guinea pig | lowest published lethal dose: 150 mg/kg | HBTXAC 1,62,1955 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 68 mg/kg | PHTOEH 64,247,1989 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 190 mg/kg | Behavioral: Ataxia Behavioral: Tetany Lung, Thorax, or Respiration: Dyspnea | VCVGK* -,224,1994 |
intravenous/cat | lowest published lethal dose: 100 mg/kg | Behavioral: Ataxia Behavioral: Tetany Lung, Thorax, or Respiration: Dyspnea | VCVGK* -,224,1994 |
intravenous/Dog | lowest published lethal dose: 40 mg/kg | Behavioral: Ataxia Behavioral: Tetany Lung, Thorax, or Respiration: Dyspnea | VCVGK* -,224,1994 |
intravenous/Dog | lowest published lethal dose: 40 mg/kg | HBTXAC 1,62,1955 | |
oral/cat | lethal dose (50 percent kill): 100 mg/kg | IPSTB3 3,93,1976 | |
oral/Dog | lethal dose (50 percent kill): 130 mg/kg | IPSTB3 3,93,1976 | |
oral/Dog | lowest published lethal dose: 130 mg/kg | Behavioral: Ataxia Behavioral: Tetany Lung, Thorax, or Respiration: Dyspnea | VCVGK* -,224,1994 |
oral/guinea pig | lethal dose (50 percent kill): 210 mg/kg | AFREAW 3,197,1951 | |
oral/mammal (species unspecified) | lethal dose (50 percent kill): 240 mg/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea | TPKVAL 15,136,1979 |
oral/mouse | lethal dose (50 percent kill): 100 mg/kg | Behavioral: Ataxia Behavioral: Tetany Lung, Thorax, or Respiration: Dyspnea | VCVGK* -,224,1994 |
oral/mouse | lethal dose (50 percent kill): 260 mg/kg | AFREAW 3,197,1951 | |
oral/rabbit | lowest published lethal dose: 200 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) Blood: Luekopenia Blood: Methemoglobinemia- Carboxhemoglobinemia | 38MKAJ 2A,2585,1981 |
oral/rabbit | lowest published lethal dose: 1000 mg/kg | Behavioral: Ataxia Behavioral: Tetany Lung, Thorax, or Respiration: Dyspnea | VCVGK* -,224,1994 |
oral/rat | lethal dose (50 percent kill): 3890 mg/kg | Behavioral: Ataxia Behavioral: Tetany Lung, Thorax, or Respiration: Dyspnea | VCVGK* -,224,1994 |
oral/rat | lowest published toxic dose: 48 mg/kg | Peripheral Nerve and Sensation: Recording from peripheral motor nerve | TPKVAL 15,136,1979 |
oral/rat | lethal dose (50 percent kill): 260 mg/kg | AFREAW 3,197,1951 | |
parenteral/frog | lowest published lethal dose: 160 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Convulsions or effect on seizure threshold | AEPPAE 166,437,1932 |
skin/rabbit | lethal dose (50 percent kill): 800 mg/kg | Skin: After topical application: Primary irritation Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AIHAAP 37,596,1976 |
skin/rabbit | lethal dose (50 percent kill): 800 mg/kg | Behavioral: Ataxia Behavioral: Tetany Lung, Thorax, or Respiration: Dyspnea | VCVGK* -,224,1994 |
subcutaneous/frog | lowest published lethal dose: 160 mg/kg | HBTXAC 1,62,1955 | |
subcutaneous/guinea pig | lowest published lethal dose: 200 mg/kg | HBTXAC 1,62,1955 | |
subcutaneous/guinea pig | lowest published lethal dose: 200 mg/kg | Behavioral: Ataxia Behavioral: Tetany Lung, Thorax, or Respiration: Dyspnea | VCVGK* -,224,1994 |
subcutaneous/mouse | lethal dose (50 percent kill): 247 mg/kg | Behavioral: Ataxia Behavioral: Tetany Lung, Thorax, or Respiration: Dyspnea | VCVGK* -,224,1994 |
subcutaneous/mouse | lethal dose (50 percent kill): 247 mg/kg | INHEAO 5,143,1967 | |
subcutaneous/rabbit | lowest published lethal dose: 225 mg/kg | JAFCAU 17,497,1969 | |
subcutaneous/rat | lowest published lethal dose: 110 mg/kg | AIPTAK 176,193,1968 | |
subcutaneous/rat | lowest published lethal dose: 200 mg/kg | Behavioral: Ataxia Behavioral: Tetany Lung, Thorax, or Respiration: Dyspnea | VCVGK* -,224,1994 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/mouse | lowest published toxic dose: 450 mg/kg/3D- intermittent | Blood: Changes in bone marrow not included in above Blood: Changes in spleen | VCVGK* -,225,1994 |
intravenous/mouse | lowest published toxic dose: 450 mg/kg/3D- intermittent | Blood: Changes in bone marrow not included in above Blood: Changes in spleen | VCVGK* -,225,1994 |
oral/chicken | lowest published toxic dose: 98 gm/kg/4W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FEPRA7 29,568,1970 |
oral/rat | lowest published toxic dose: 15470 mg/kg/34W- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | JTPAE7 29,180,2001 |
oral/rat | lowest published toxic dose: 2226 mg/kg/7D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTPAE7 29,180,2001 |
oral/rat | lowest published toxic dose: 360 mg/kg/5D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Lipids including transport | PHREP* 57,70,2005 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 ppm (skin) | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 71,433,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 15,155,1977 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 15,155,1977 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 71,433,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 71,433,1999 |
TOXICOLOGY REVIEW | MUREAV 47,75,1978 | |
TOXICOLOGY REVIEW | MUREAV 566,99,2004 | |
TOXICOLOGY REVIEW | MUREAV 567,227,2004 | |
TOXICOLOGY REVIEW | MUREAV 567,109,2004 | |
TOXICOLOGY REVIEW | MUREAV 567,151,2004 | |
TOXICOLOGY REVIEW | MUREAV 627,10,2007 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | BCLPT* 96,131,2005 | |
TOXICOLOGY REVIEW | MUREAV 682,94,2009 | |
TOXICOLOGY REVIEW | MUTAEX 23,271,2008 | |
TOXICOLOGY REVIEW | FITOT* 82,513,2011 | |
TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
TOXICOLOGY REVIEW | FCTOD7 55,596,2013 | |
TOXICOLOGY REVIEW | EMMUEG 55,679,2014 | |
TOXICOLOGY REVIEW | MUREAV 802,1,2016 | |
TOXICOLOGY REVIEW | FCTOD7 94,93,2016 | |
TOXICOLOGY REVIEW | RTOPDW 55,43,2009 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CATECHOL-air | 10H time-weighted average 5 ppm (Sk) | NIOSH* DHHS #95-121,1995 |
National Occupational Exposure Survey 1983 | Hazard Code M1763; Number of Industries 8; Total Number of Facilities 700; Number of Occupations 15; Total Number of Employees Exposed 13516; Total Number of Female Employees Exposed 5799 | |
National Occupational Hazard Survey 1974 | Hazard Code M1763; Number of Industries 4; Total Number of Facilities 147; Number of Occupations 6; Total Number of Employees Exposed 642 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health