Propionitrile, 3-(dimethylamino)-

RTECS #

UG1575000

CAS #

1738-25-6
See: NMAM or OSHA Methods

Updated

February 2007

Molecular Weight

98.17

Molecular Formula

C₅H₁₀N₂

Synonyms

3-(Dimethylamino)propionitrile
3-Dimethylaminopropannitril (Czech)
beta-Dimethylaminopropionitrile

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	20 mg/24H	moderate	85JCAE -,923,1986
skin /rabbit	500 mg/24H	mild	85JCAE -,923,1986

Route/Organism	Dose	Reference
intraperitoneal/rat	lethal dose (50 percent kill): 500 mg/kg	TOVEFN (1),19,1996
intravenous/mouse	lethal dose (50 percent kill): 180 mg/kg	CSLNX* NX#00201
oral/mouse	lethal dose (50 percent kill): 1500 mg/kg	85JCAE -,923,1986
oral/rat	lethal dose (50 percent kill): 2600 µL/kg	AIHAAP 23,95,1962
skin/rabbit	lethal dose (50 percent kill): 1410 µL/kg	AIHAAP 23,95,1962

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 9 mg/m³/122D- intermittent	Brain and Coverings: Other degenerative changes Cardiac: Other changes Liver: Other changes	TOVEFN (1),19,1996
inhalation/rat	lowest published toxic concentration: 9 mg/m³/122D- intermittent	Kidney, Ureter, and Bladder: Other changes	TOVEFN (1),19,1996
inhalation/rat	lowest published toxic concentration: 9 mg/m³/122D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	TOVEFN (1),19,1996
intraperitoneal/rat	lowest published toxic dose: 500 mg/kg/3D- intermittent	Liver: Liver function tests impaired Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TOVEFN (1),19,1996
intraperitoneal/rat	lowest published toxic dose: 182.6 mg/kg/30D- intermittent	Liver: Liver function tests impaired Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TOVEFN (1),19,1996

Organization	Standard	Reference
Occupational Exposure Limit-RUSSIA	short term exposure limit 10 mg/m³, JUN2003

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLAMINOPROPIONITRILE-air	min expos to NIAX	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	Hazard Code M3293; Number of Industries 2; Total Number of Facilities 145; Number of Occupations 3; Total Number of Employees Exposed 1990

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 26, 1978

Page last reviewed: November 16, 2018