2-Propenoic acid, butyl ester

RTECS #

UD3150000

CAS #

141-32-2
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

128.19

Molecular Formula

C₇H₁₂O₂

Synonyms

Acrylic acid n-butyl ester
Acrylic acid, butyl ester
Butyl 2-propenoate
Butyl acrylate
Butylester kyseliny akrylove (Czech)
n-Butyl acrylate
n-Butyl acrylate (ACGIH)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	50 mg	mild	UCDS** 4/5/1973
eye /rabbit	500 mg/24H	mild	85JCAE -,370,1986
skin /rabbit	10 mg/24H open irritation test	mild	AMIHBC 4,119,1951
skin /rabbit	500 mg open irritation test	mild	UCDS** 4/5/1973
skin /woman	0.1%/48H		CODEDG 57,21,2007

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	135 ppm/6H (6-15D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	FAATDF 3,443,1983
inhalation/rat	135 ppm/6H (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	NTIS** OTS0534614
inhalation/rat	200 ppm/6H (6-20D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TOSCF2 48,240,1999
inhalation/rat	200 ppm (6-20D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other effects on female	TOSCF2 48,240,1999

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mammal (species unspecified)	lethal concentration (50 percent kill): 7800 mg/m³		GISAAA 51(5),61,1986
inhalation/mouse	lethal concentration (50 percent kill): 7800 mg/m³/2H		85GMAT -,28,1982
inhalation/rat	lethal concentration (50 percent kill): 2730 ppm/4H	Olfaction: Other olfaction effects Eye: Other eye effects Lung, Thorax, or Respiration: Dyspnea	JTEHD6 16,811,1985
inhalation/rat	lowest published toxic concentration: 5.05 gm/m³/6H	Liver: Other changes Endocrine: Hyperglycemia Biochemical: Metabolism (intermediary): Other	TXCYAC 65,209,1990
intraperitoneal/mouse	lethal dose (50 percent kill): 200 mL/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation	NTIS** OTS05220809
intraperitoneal/rat	lethal dose (50 percent kill): 550 mg/kg		AMPMAR 36,58,1975
oral/mouse	lethal dose (50 percent kill): 5880 mg/kg	Lung, Thorax, or Respiration: Other changes	GTPZAB 25(11),57,1981
oral/rabbit	lowest published lethal dose: 2 mL/kg		NTIS** OTS0520808
oral/rat	lethal dose (50 percent kill): 900 mg/kg		85GMAT -,28,1982
skin/rabbit	lethal dose (50 percent kill): 2 mL/kg		TXAPA9 28,313,1974
skin/rat	lowest published lethal dose: 1700 mg/kg		PJPPAA 32,223,1980

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 211 ppm/6H/13W- intermittent	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0555423
oral/rat	lowest published toxic dose: 13650 mg/kg/13W- intermittent	Liver: Changes in liver weight	TOXID9 2,33,1982

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 2 ppm (sen)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 39,67,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 71,359,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 39,67,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Evidence	IMEMDT 71,359,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 71,359,1999
TOXICOLOGY REVIEW		EVHPAZ 11,141,1975
TOXICOLOGY REVIEW		RTOPDW 54,247,2009

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 ppm (5 mg/m³), short term exposure limit 5 ppm (26 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 2 ppm (11 mg/m³);KZW 10 ppm (53 mg/m³), sen, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 2 ppm (11 mg/m³), short term exposure limit 10 ppm (53 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 2 ppm (11 mg/m³), MAY2011
Occupational Exposure Limit-EC	time-weighted average 11 mg/m³ (2 ppm);short term exposure limit 53 mg/m³ (10 ppm), JUN2000
Occupational Exposure Limit-FINLAND	time-weighted average 2 ppm (11 mg/m³), short term exposure limit 10 ppm (53 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 2 ppm (11 mg/m³), VLE 10 ppm (53 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 2 ppm (11 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 11 mg/m³, short term exposure limit 53 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 2 ppm (11 mg/m³), short term exposure limit 10 ppm (53 mg/m³), sen, NOV2011
Occupational Exposure Limit-JAPAN	s2 sen, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 10 ppm (55 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 ppm (55 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 ppm (52 mg/m³), sen, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 10 ppm (55 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 2 ppm (10.5 mg/m³); short term exposure limit 10 ppm (52 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	time-weighted average 20 mg/m³, short term exposure limit 70 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 10 mg/m³, short term exposure limit 30 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 10 ppm (50 mg/m³);short term exposure limit 15 ppm (80 mg/m³), Sen, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 2 ppm (11 mg/m³), KZG-week 4 ppm (22 mg/m³), sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1 1 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 1 ppm (5 mg/m³);short term exposure limit 5 ppm (26 mg/m³), OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BUTYL ACRYLATE-air	10H time-weighted average 10 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 84295; Number of Industries 33; Total Number of Facilities 2948; Number of Occupations 40; Total Number of Employees Exposed 39848; Total Number of Female Employees Exposed 6688
National Occupational Hazard Survey 1974	Hazard Code 84295; Number of Industries 28; Total Number of Facilities 2222; Number of Occupations 33; Total Number of Employees Exposed 16374

Status in Federal Agencies

Organization	Reference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health