2-Propanol, 1-methoxy-

RTECS #

UB7700000

CAS #

107-98-2
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

90.14

Molecular Formula

C₄H₁₀O₂

Synonyms

1-Methoxy-2-propanol
alpha-Propylene glycol monomethyl ether
Dowanol 33B
Dowanol PM
Dowanol PM glycol ether
Dowtherm 209
Glycol ether PM
Methoxy ether of propylene glycol
Methyl proxitol
PGME
Poly-Solve MPM
Propasol solvent M
Propylene glycol methyl ether
Propylene glycol monomethyl ether
Propylene glycol monomethyl ether (ACGIH)
Propylenglykol-monomethylaether (German)
Ucar Solvent LM (Obs.)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	500 mg/24H	mild	85JCAE -,625,1986
skin /rabbit	500 mg open irritation test	mild	UCDS** 11/15/1971

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	3000 ppm/6H (6-15D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	FAATDF 4,784,1984
inhalation/rat	3000 ppm/6H (multigeneration)	Reproductive: Other effects on female Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Physical	TOSCF2 50,249,1999
oral/mouse	3.3 gm/kg (multigenerations)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB86170578
oral/mouse	3.3 gm/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Hepatobiliary system	NTIS** #PB86170578
oral/mouse	3.3 gm/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB86170578
oral/mouse	115.5 gm/kg (7D male/7D prior to copulation/21D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB86170578
oral/rabbit	936 mg/kg (7-19D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	TOSCF2 71,217,2003
oral/rat	50501.25 mg/kg (15D prior to copulation)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	TIHEEC 21,33,2005
oral/rat	59395.5 mg/kg (15D prior to copulation)	Reproductive: Other effects on female Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	TIHEEC 21,33,2005

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	Lowest published lethal concentration: 15000 ppm/7H	Behavioral: Sleep	AMIHBC 9,509,1954
inhalation/human	lowest published toxic concentration: 3000 ppm	Olfaction: Tumors Behavioral: General anesthetic Gastrointestinal: Nausea or vomiting	NPIRI* 1,105,1974
inhalation/human	lowest published toxic concentration: 2580 mg/m³	Eye: Lacrimation	VCVGK* -,169,1984
inhalation/human	lowest published toxic concentration: 7540 mg/m³	Eye: Conjunctiva irritation	VCVGK* -,169,1984
inhalation/human	lowest published toxic concentration: 830 mg/m³/1H	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVGK* -,170,1984
inhalation/mouse	lowest published toxic concentration: 1000 ppm	Liver: Other changes	TOXID9 72,178,2003
inhalation/mouse	lowest published toxic concentration: 3000 ppm	Behavioral: Antianxiety	TOXID9 72,178,2003
inhalation/rabbit	Lowest published lethal concentration: 15000 ppm/7H		AMIHBC 9,509,1954
inhalation/rat	lowest published toxic concentration: 18400 mg/m³	Behavioral: Alteration of classical conditioning	VCVGK* -,169,1984
inhalation/rat	lethal concentration (50 percent kill): 10000 ppm/5H		NPIRI* 1,105,1974
inhalation/rat	lowest published toxic concentration: 3000 ppm	Behavioral: Antianxiety	TOXID9 72,178,2003
inhalation/rat	lowest published toxic concentration: 1000 ppm	Liver: Other changes	TOXID9 72,178,2003
inhalation/rat	lowest published toxic concentration: 1000 ppm	Kidney, Ureter, and Bladder: Other changes	TOXID9 72,178,2003
intraperitoneal/mouse	Lethal dose: >500 mg/kg		CBCCT* 4,110,1952
intraperitoneal/rat	lethal dose (50 percent kill): 3720 mg/kg		38MKAJ 2C,3977,1982
intravenous/Dog	lethal dose (50 percent kill): 2 gm/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	ARZNAD 22,569,1972
intravenous/mouse	lethal dose (50 percent kill): 5300 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	ARZNAD 22,569,1972
intravenous/rabbit	lethal dose (50 percent kill): 1200 mg/kg		ARZNAD 22,569,1972
intravenous/rat	lethal dose (50 percent kill): 4200 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	ARZNAD 22,569,1972
oral/Dog	lethal dose (50 percent kill): 5 gm/kg		ARZNAD 22,569,1972
oral/mouse	lethal dose (50 percent kill): 11700 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	ARZNAD 22,569,1972
oral/rabbit	lethal dose (50 percent kill): 5700 mg/kg		ARZNAD 22,569,1972
oral/rat	lethal dose (50 percent kill): 6600 mg/kg	Brain and Coverings: Other degenerative changes Behavioral: General anesthetic Lung, Thorax, or Respiration: Dyspnea	VCVGK* -,169,1984
oral/rat	lowest published lethal dose: 3739 mg/kg	Eye: Chromodacryorrhea Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia	NTIS** OTS0520402
skin/rabbit	lethal dose (50 percent kill): 13 gm/kg		NPIRI* 1,105,1974
subcutaneous/rabbit	lethal dose (50 percent kill): 5 gm/kg		ARZNAD 22,569,1972
subcutaneous/rat	lethal dose (50 percent kill): 7800 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	ARZNAD 22,569,1972

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lowest published toxic concentration: 6000 ppm/7H/16W- intermittent	Behavioral: General anesthetic Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AMIHBC 9,509,1954
inhalation/monkey	lowest published toxic concentration: 10000 ppm/4H/13W- intermittent	Liver: Other changes Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AMIHBC 9,509,1954
inhalation/mouse	lowest published toxic concentration: 3000 ppm/6H/11D- intermittent	Liver: Changes in liver weight	TXAPA9 61,368,1981
inhalation/rabbit	lowest published toxic concentration: 3000 ppm/6H/13W- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	FAATDF 3,627,1983
inhalation/rat	lowest published toxic concentration: 3000 ppm/6H/11D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Other changes in urine composition	TXAPA9 61,368,1981
inhalation/rat	lowest published toxic concentration: 3000 ppm/6H/13W- intermittent	Liver: Changes in liver weight	FAATDF 3,627,1983
inhalation/rat	lowest published toxic concentration: 11000 mg/m³/6H/9D- intermittent	Brain and Coverings: Other degenerative changes Liver: Changes in liver weight Kidney, Ureter, and Bladder: Other changes in urine composition	VCVGK* -,170,1994
inhalation/rat	lowest published toxic concentration: 2200 mg/m³/12D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	VCVGK* -,170,1994
multiple/human	lowest published toxic dose: 100 ppm/3H/2W- intermittent	Olfaction: Other olfaction effects	TOLED5 135,S30,2002
multiple/human	lowest published toxic dose: 150 ppm/3H/2W- intermittent	Olfaction: Other olfaction effects Eye: Conjunctiva irritation	TOLED5 135,S30,2002
oral/mouse	lowest published toxic dose: 40 mL/kg/2W- intermittent	Liver: Hepatitis (hepatocellular necrosis), diffuse Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,170,1994
oral/mouse	lowest published toxic dose: 40 mL/kg/2W- intermittent	Liver: Hepatitis (hepatocellular necrosis), diffuse Blood: Luekopenia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,170,1994
oral/rat	lowest published toxic dose: 40 mL/kg/2W- intermittent	Liver: Hepatitis (hepatocellular necrosis), diffuse Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,170,1994
oral/rat	lowest published toxic dose: 40 mL/kg/2W- intermittent	Liver: Hepatitis (hepatocellular necrosis), diffuse Blood: Luekopenia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,170,1994
oral/rat	lowest published toxic dose: 280435.2 mg/kg/64D- continuous	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	TIHEEC 21,33,2005
skin/rabbit	lowest published toxic dose: 900 mL/kg/90D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,170,1994
skin/rabbit	lowest published toxic dose: 455 mL/kg/13W- intermittent	Behavioral: General anesthetic Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHBC 9,509,1954

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 50 ppm;short term exposure limit 100 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		FAATDF 13,747,1989
TOXICOLOGY REVIEW		CRTXB2 30,307,2000
TOXICOLOGY REVIEW		TOLED5 140-141,249,2003
TOXICOLOGY REVIEW		ENTOX* -,451,2005
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009
TOXICOLOGY REVIEW		TOLED5 199,203,2010
TOXICOLOGY REVIEW		RTOPDW 60,120,2011

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 100 ppm (360 mg/m³)	DTLWS* 3,27,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 100 ppm (369 mg/m³), short term exposure limit 150 ppm (553 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 50 ppm (187 mg/m³);KZW 50 ppm (187 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 100 ppm (375 mg/m³), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 150 ppm (568 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 50 ppm (185 mg/m³), MAY2011
Occupational Exposure Limit-EC	time-weighted average 375 mg/m³ (100 ppm);short term exposure limit 568 mg/m³ (150 ppm), skin, JUN2000
Occupational Exposure Limit-FINLAND	time-weighted average 100 ppm (370 mg/m³), short term exposure limit 150 ppm (560 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 100 ppm (375 mg/m³), VLE 150 ppm (568 mg/m³), Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 100 ppm (370 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 375 mg/m³, short term exposure limit 568 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 50 ppm (185 mg/m³), short term exposure limit 150 ppm (568 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 100 ppm (360 mg/m³), short term exposure limit 150 ppm (540 mg/m³), 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 100 ppm (369 mg/m³), short term exposure limit 150 ppm (553 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 50 ppm (180 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 100 ppm (369 mg/m³); short term exposure limit 150 ppm (553 mg/m³), JUL2005
Occupational Exposure Limit-SWEDEN	time-weighted average 50 ppm (190 mg/m³);short term exposure limit 75 ppm (300 mg/m³), Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 100 ppm (360 mg/m³), KZG-week 200 ppm (720 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 375 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 100 ppm (375 mg/m³);short term exposure limit 150 ppm (560 mg/m³), skin, OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air	10H time-weighted average 100 ppm;short term exposure limit 150 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 81815; Number of Industries 204; Total Number of Facilities 25947; Number of Occupations 133; Total Number of Employees Exposed 373990; Total Number of Female Employees Exposed 110572
National Occupational Hazard Survey 1974	Hazard Code 81815; Number of Industries 44; Total Number of Facilities 5953; Number of Occupations 36; Total Number of Employees Exposed 26413

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
OSHA ANALYTICAL METHOD #99

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health