Propane, 1,2,3-trichloro-
RTECS #
TZ9275000
CAS #
Updated
March 2018
Molecular Weight
147.43
Molecular Formula
C3H5Cl3
Synonyms
1,2,3-Trichloropropane
1,2,3-Trichloropropane (ACGIH:OSHA)
Allyl trichloride
Glycerol trichlorohydrin
Glyceryl trichlorohydrin
NCI-C60220
Trichlorohydrin
1,2,3-Trichloropropane (ACGIH:OSHA)
Allyl trichloride
Glycerol trichlorohydrin
Glyceryl trichlorohydrin
NCI-C60220
Trichlorohydrin
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 100 µL | moderate | NTIS** OTS0534994 |
skin /rabbit | 500 µL/24H | mild | NTIS** OTS0534994 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | inhalation/rat | 800 µg/L | BEXBAN 78,1414,1974 |
DNA Damage | lymphocyte/human | 2 mmol/L | MUREAV 371,185,1996 |
DNA Damage | intraperitoneal/rat | 55361 µg/kg | CRTOEC 4,528,1991 |
mutation in microorganisms | /Salmonella typhimurium | 500 ng/plate (-enzymatic activation step) | ENMUDM 7(Suppl 3),15,1985 |
sister chromatid exchange | lung/hamster | 300 µmol/L | ENMUDM 9,401,1987 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | 400 mg/kg (5D male) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | MUREAV 101,321,1982 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/mouse | lowest published toxic dose: 3120 mg/kg/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Liver: Tumors | NTPTR* NTP-TR-384,1993 |
oral/mouse | lowest published toxic dose: 3120 mg/kg/104W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Liver: Tumors | NTIS** PB94-207784 |
oral/mouse | lowest published toxic dose: 31200 mg/kg/104W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Endocrine: Tumors | NTIS** PB94-207784 |
oral/mouse | lowest published toxic dose: 1183 mg/kg/13W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors | MUREAV 746,135,2012 |
oral/rat | lowest published toxic dose: 5200 mg/kg/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Skin and Appendages: Tumors | NTPTR* NTP-TR-384,1993 |
oral/rat | lowest published toxic dose: 1560 mg/kg/104W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | NTIS** PB94-207784 |
oral/rat | lowest published toxic dose: 15600 mg/kg/104W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Endocrine: Tumors Reproductive: Other reproductive system tumors | NTIS** PB94-207784 |
oral/rat | lowest published toxic dose: 5200 mg/kg/104W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors Reproductive: Other reproductive system tumors | NTIS** PB94-207784 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lethal concentration (50 percent kill): 3400 mg/m3/2H | VCVGH* -,397,1990 | |
inhalation/rat | Lowest published lethal concentration: 500 ppm/4H | UCDS** 3/20/1973 | |
oral/Dog | lowest published lethal dose: 200 mg/kg | Behavioral: Sleep Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Fatty liver degeneration | AJHYA2 16,325,1932 |
oral/guinea pig | lethal dose (50 percent kill): 340 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Blood: Other changes | TKGMB8 124,27,1976 |
oral/mouse | lethal dose (50 percent kill): 369 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Blood: Other changes | TKGMB8 124,27,1976 |
oral/rabbit | lethal dose (50 percent kill): 380 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Blood: Other changes | TKGMB8 124,27,1976 |
oral/rat | lethal dose (50 percent kill): 108 µL/kg | Gastrointestinal: Hypermotility, diarrhea Liver: Other changes Skin and Appendages: Other: Hair | NTIS** OTS0534994 |
skin/rabbit | lethal dose (50 percent kill): 372 µL/kg | Gastrointestinal: Hypermotility, diarrhea Lung, Thorax, or Respiration: Other changes Gastrointestinal: Other changes | NTIS** OTS0534994 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic concentration: 3210 mg/m3/5H/23D- intermittent | Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGH* -,398,1990 |
inhalation/rat | lowest published toxic concentration: 297 ppm/6H/4W- intermittent | Liver: Changes in liver weight Endocrine: Changes in spleen weight Related to Chronic Data: Changes in ovarian weight | JTEHD6 25,299,1988 |
inhalation/rat | lowest published toxic concentration: 2 mg/m3/24H/94D- continuous | Brain and Coverings: Recordings from specific areas of CNS Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 42(8),50,1977 |
inhalation/rat | lowest published toxic concentration: 15 ppm/6H/13W- intermittent | Eye: Lacrimation Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0542010 |
oral/mouse | lowest published toxic dose: 5355 mg/kg/17W- intermittent | Lung, Thorax, or Respiration: Other changes Gastrointestinal: Other changes | NTPTR* NTP-TR-384,1993 |
oral/mouse | lowest published toxic dose: 1519.7 mg/kg/13W- intermittent | Lung, Thorax, or Respiration: Other changes | MUREAV 746,135,2012 |
oral/rat | lowest published toxic dose: 2720 mg/kg/17W- intermittent | Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | NTPTR* NTP-TR-384,1993 |
oral/rat | lowest published toxic dose: 1179 mg/kg/10D- intermittent | Cardiac: Other changes Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | JJATDK 11,179,1991 |
unreported route/rat | lowest published toxic dose: 3210 mg/m3/90D- intermittent | Brain and Coverings: Changes in brain weight Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGH* -,398,1990 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 10 ppm (skin) | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 63,223,1995 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 63,223,1995 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 2A | IMEMDT 63,223,1995 |
TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
TOXICOLOGY REVIEW | MUREAV 567,151,2004 | |
TOXICOLOGY REVIEW | FCTOD7 44,1699,2006 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | HTOPA* 1,501,2002 | |
TOXICOLOGY REVIEW | MUTAEX 23,271,2008 | |
TOXICOLOGY REVIEW | MUREAV 705,184,2010 | |
TOXICOLOGY REVIEW | FCTOD7 48,1488,2010 | |
TOXICOLOGY REVIEW | MUREAV 751,49,2012 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 50 ppm (300 mg/m3) | DTLVS* 3,266,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 ppm (60 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 50 ppm (300 mg/m3);KZW 250 ppm (1500 mg/m3), 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 10 ppm (61 mg/m3), Skin, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.1 ppm (0.6 mg/m3), skin, carc, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 3 ppm (18 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-ICELAND | time-weighted average 10 ppm (60 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-JAPAN | 2A carc, MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 10 ppm (60 mg/m3), skin, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 50 ppm (300 mg/m3);short term exposure limit 75 ppm (450 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 ppm (60 mg/m3), skin, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 10 ppm (60 mg/m3), JAN1999 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 2 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWITZERLAND | carc 2, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.108 mg/m3, Skin, 2003 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 50 ppm (300 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 50 ppm (300 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 50 ppm (300 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 50 ppm (300 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,2,3-TRICHLOROPROPANE-air | 10H Carcinogen time-weighted average 10 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 73960; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 7; Total Number of Employees Exposed 492; Total Number of Female Employees Exposed 10 | |
National Occupational Hazard Survey 1974 | Hazard Code 73960; Number of Industries 4; Total Number of Facilities 108; Number of Occupations 5; Total Number of Employees Exposed 490 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health