Propane, 2-nitro-
RTECS #
TZ5250000
CAS #
Updated
March 2018
Molecular Weight
89.11
Molecular Formula
C3H7NO2
Synonyms
2-Nitropropane
2-Nitropropane (ACGIH:OSHA)
2-NP
beta-Nitropropane
Dimethylnitromethane
Isonitropropane
Nipar S-20
Nipar S-20 solvent
Nipar S-30 solvent
Nitroisopropane
RCRA waste number U171
2-Nitropropane (ACGIH:OSHA)
2-NP
beta-Nitropropane
Dimethylnitromethane
Isonitropropane
Nipar S-20
Nipar S-20 solvent
Nipar S-30 solvent
Nitroisopropane
RCRA waste number U171
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 0.1 mL | mild | HPV054 -,-,2005 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | lymphocyte/human | 60 mmol/L | MUREAV 190,217,1987 |
DNA Damage | /Salmonella typhimurium | 50 mg/L | MUREAV 104,49,1982 |
DNA Damage | oral/rat | 44555 µg/kg | CALEDQ 57,61,1991 |
DNA Damage | intraperitoneal/rat | 100 mg/kg | MUREAV 391,165,1997 |
DNA Damage | unreported route/mouse | 100 mg/kg | MUREAV 577S,1,2005 |
DNA Damage | fibroblast/hamster | 3 mmol/L/6H | MUREAV 726,84,2011 |
DNA repair | intraperitoneal/rat | 20 mg/kg | CRNGDP 9,811,1988 |
DNA repair | liver/rat | 30 µmol/L | CRNGDP 9,811,1988 |
DNA repair | other cell types/domestic animal | 2 mmol/L | MUREAV 413,69,1998 |
micronucleus test | oral/rat | 25 mg/kg | CRNGDP 10,2329,1989 |
micronucleus test | oral/rat | 560 mg/kg/14D | MUREAV 780-781,2,2015 |
micronucleus test | oral/rat | 140 mg/kg/28D | MUREAV 780-781,2,2015 |
mutation in microorganisms | /Escherichia coli | 2500 µg/plate (+/-enzymatic activation step) | SAIGBL 29,34,1987 |
mutation in microorganisms | /Salmonella typhimurium | 25 µmol/L (+enzymatic activation step) | FAATDF 13,341,1989 |
mutation in microorganisms | /Salmonella typhimurium | 1 mg/plate (-enzymatic activation step) | ENMUDM 5(Suppl 1),3,1983 |
sister chromatid exchange | lymphocyte/human | 7500 µmol/L | MUREAV 190,217,1987 |
Unscheduled DNA Synthesis | liver/rat | 1 µmol/L | MUREAV 221,263,1989 |
Unscheduled DNA Synthesis | intraperitoneal/rat | 20 mg/kg | CRNGDP 9,811,1988 |
Unscheduled DNA Synthesis | oral/rat | 50 mg/kg | CRNGDP 10,2329,1989 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/rat | 2550 mg/kg (1-15D pregnant) | Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | TXAPA9 48,A35,1979 |
intraperitoneal/rat | 2550 mg/kg (1-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | SWEHDO 7(Suppl 4),66,1981 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 207 ppm/7H/26W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | JEPTDQ 2(5),233,1979 |
inhalation/rat | toxic concentration: 207 ppm/26W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors | XPHCI* 25APR1977 |
inhalation/rat | lowest published toxic concentration: 207 ppm/24W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains | HPV054 -,-,2005 |
oral/rat | lowest published toxic dose: 4277 mg/kg/16W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | CRNGDP 8,1947,1987 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/cat | Lowest published lethal concentration: 714 ppm/5H | Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | AMIHBC 5,52,1952 |
inhalation/guinea pig | Lowest published lethal concentration: 4622 ppm/5H | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis | AMIHBC 5,52,1952 |
inhalation/man | lowest published toxic concentration: 20 ppm | Behavioral: Anorexia (human) Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Nausea or vomiting | INMEAF 16,441,1947 |
inhalation/mouse | lethal concentration (50 percent kill): 10 gm/m3/2H | 85GMAT -,94,1982 | |
inhalation/mouse | lethal concentration (50 percent kill): 558 ppm/6H | Lung, Thorax, or Respiration: Other changes Blood: Hemorrhage | HPV054 -,-,2005 |
inhalation/rabbit | Lowest published lethal concentration: 2381 ppm/5H | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis | AMIHBC 5,52,1952 |
inhalation/rat | lethal concentration (50 percent kill): 12070 mg/m3/1H | Eye: Conjunctiva irritation Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression | HPV054 -,-,2005 |
inhalation/rat | lethal concentration (50 percent kill): 400 ppm/6H | HPV054 -,-,2005 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 75 mg/kg | NTIS** AD691-490 | |
intraperitoneal/rat | lowest published lethal dose: 1100 mg/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | BSPLA9 (2),83,1972 |
intraperitoneal/rat | lowest published toxic dose: 100 mg/kg | Liver: Hepatitis (hepatocellular necrosis), diffuse Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Lipids including transport | TXCYAC 210,1,2005 |
intraperitoneal/rat | lowest published toxic dose: 100 mg/kg | Liver: Other changes Biochemical: Metabolism (intermediary): Other | TOXID9 1,93,2001 |
oral/mouse | lethal dose (50 percent kill): 393 mg/kg | HPV054 -,-,2005 | |
oral/rabbit | lethal dose (50 percent kill): 500 mg/kg | Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression | HPV054 -,-,2005 |
oral/rabbit | lowest published lethal dose: 500 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory stimulation | JIHTAB 22,315,1940 |
oral/rat | lethal dose (50 percent kill): 565 mg/kg | HPV054 -,-,2005 | |
skin/rabbit | lethal dose (50 percent kill): >2000 mg/kg | HPV054 -,-,2005 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rabbit | lowest published toxic concentration: 207 ppm/24W- intermittent | Lung, Thorax, or Respiration: Other changes Blood: Hemorrhage Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | HPV054 -,-,2005 |
inhalation/rat | lowest published toxic concentration: 200 ppm/5D- intermittent | Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV054 -,-,2005 |
inhalation/rat | lowest published toxic concentration: 400 ppm/3D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV054 -,-,2005 |
inhalation/rat | lowest published toxic concentration: 207 ppm/24W- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | HPV054 -,-,2005 |
oral/rat | lowest published toxic dose: 720 mg/kg/2W- continuous | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | ETPAEK 61,197,2009 |
oral/rat | lowest published toxic dose: 560 mg/kg/14D- intermittent | Liver: Tumors | MUREAV 780-781,2,2015 |
oral/rat | lowest published toxic dose: 560 mg/kg/28D- intermittent | Liver: Changes in liver weight | MUREAV 780-781,2,2015 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 10 ppm | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 29,331,1982 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 71,1079,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 29,331,1982 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 71,1079,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 71,1079,1999 |
TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
TOXICOLOGY REVIEW | MUREAV 588,88,2005 | |
TOXICOLOGY REVIEW | MUREAV 628,31,2007 | |
TOXICOLOGY REVIEW | MUREAV 705,184,2010 | |
TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
TOXICOLOGY REVIEW | TXAPA9 254,86,2011 | |
TOXICOLOGY REVIEW | MUREAV 786-788,14,2015 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 25 ppm (90 mg/m3) | DTLVS* 3,188,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 ppm (36 mg/m3), Carcinogen, JUL2008 | |
Occupational Exposure Limit-AUSTRIA | TRK-TMW 5 ppm (18 mg/m3);KZW 20 ppm (72 mg/m3), 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 10 ppm (37 mg/m3), Carcinogen, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 5 ppm (18 mg/m3), carc, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 5 ppm (18 mg/m3), short term exposure limit 40 ppm (150 mg/m3), NOV2011 | |
Occupational Exposure Limit-HUNGARY | ceiling concentration 18 mg/m3, Carcinogen, SEP2000 | |
Occupational Exposure Limit-ICELAND | time-weighted average 5 ppm (18 mg/m3), short term exposure limit 10 ppm (35 mg/m3), carc, NOV2011 | |
Occupational Exposure Limit-JAPAN | 2B carc, MAY2012 | |
Occupational Exposure Limit-KOREA | ceiling concentration 10 ppm (35 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 25 ppm (90 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 ppm (19 mg/m3), JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 10 ppm (35 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 10 ppm (36 mg/m3), JUL2005 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 2 ppm (7 mg/m3), ceiling concentration 6 ppm (20 mg/m3), Carcinogen, JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 5 ppm (18 mg/m3), carc 2, skin, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.036 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 25 ppm (90 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 25 ppm (90 mg/m3), JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 5 ppm (19 mg/m3), OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 25 ppm (90 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 25 ppm (90 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 25 ppm (90 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 25 ppm (90 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2-NITROPROPANE-air | Carcinogen lowest feasible conc. | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 51090; Number of Industries 15; Total Number of Facilities 345; Number of Occupations 19; Total Number of Employees Exposed 9818; Total Number of Female Employees Exposed 1817 | |
National Occupational Hazard Survey 1974 | Hazard Code 51090; Number of Industries 57; Total Number of Facilities 2335; Number of Occupations 42; Total Number of Employees Exposed 29842 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health