Plumbane, tetramethyl-
RTECS #
TP4725000
CAS #
Updated
March 2018
Molecular Weight
267.35
Molecular Formula
C4H12Pb
Synonyms
Lead, tetramethyl-
Piombo tetra-metile (Italian)
Tetramethyl lead
Tetramethyl lead (ACGIH:OSHA)
Tetramethylolovo (Czech)
Tetramethylplumbane
TML
Piombo tetra-metile (Italian)
Tetramethyl lead
Tetramethyl lead (ACGIH:OSHA)
Tetramethylolovo (Czech)
Tetramethylplumbane
TML
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | 112 mg/kg (9-11D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TXAPA9 21,265,1972 |
oral/rat | 80 mg/kg (9-11D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 21,265,1972 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lethal concentration (50 percent kill): 8500 mg/m3/30M | 85JCAE -,1258,1986 | |
inhalation/rat | Lethal concentration: >9840 mg/m3/1H | BJIMAG 18,277,1961 | |
intraperitoneal/rat | lethal dose (50 percent kill): 90 mg/kg | MELAAD 54,486,1963 | |
intravenous/rabbit | lowest published lethal dose: 90 mg/kg | Eye: Other eye effects Behavioral: Muscle weakness Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JPETAB 38,161,1930 |
intravenous/rat | lethal dose (50 percent kill): 88 mg/kg | MELAAD 54,486,1963 | |
oral/guinea pig | lethal dose (50 percent kill): 109 mg/kg | YAKUD5 22,455,1980 | |
oral/rabbit | lowest published lethal dose: 24 mg/kg | SAIGBL 15,3,1973 | |
oral/rat | lethal dose (50 percent kill): 105 mg/kg | MELAAD 54,486,1963 | |
parenteral/rat | lethal dose (50 percent kill): 105 mg/kg | AOHYA3 3,226,1961 | |
skin/rabbit | lowest published lethal dose: 3391 mg/kg | SAIGBL 15,3,1973 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 900 mg/m3/1H/5D- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Irritability Lung, Thorax, or Respiration: Other changes | NTIS** OTS0533656-1 |
intravenous/monkey | lowest published toxic dose: 42 mg/kg/7D- intermittent | Kidney, Ureter, and Bladder: Other changes in urine composition | TOLED5 2,187,1978 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.15 mg(Pb)/m3 (skin) | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | 85DHAX Pb,255,1972 | |
TOXICOLOGY REVIEW | MUREAV 770,119,2016 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.15 mg(Pb)/m3 (skin) | DTLVS* 3,253,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 0.05 mg(Pb)/m3, JAN1993 | |
Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.15 mg(Pb)/m3, JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.05 mg/m3;KZW 0.2 mg/m3, skin, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.15 mg(Pb)/m3, Skin, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.007 ppm (0.05 mg(Pb)/m3), skin, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.075 mg(Pb)/m3, short term exposure limit 0.23 mg(Pb)/m3, skin, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 0.15 mg(Pb)/m3, Skin, FEB2006 | |
Occupational Exposure Limit-GERMANY | MAK 0.05 mg(Pb)/m3, skin, 2011 | |
Occupational Exposure Limit-HUNGARY | time-weighted average 0.05 mg/m3, short term exposure limit 0.2 mg/m3, Skin, SEP2000 | |
Occupational Exposure Limit-ICELAND | time-weighted average 0.05 mg/m3, skin, NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 0.075 mg/m3, skin, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 0.15 mg(Pb)/m3;short term exposure limit 0.5 mg(Pb)/m3 (skin), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.15 mg(Pb)/m3, skin, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 0.01 ppm (0.075 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 0,15 mg/m3, JUL2005 | |
Occupational Exposure Limit-RUSSIA | time-weighted average 0.05 mg(Pb)/m3, JUN2003 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 0.05 mg(Pb)/m3;short term exposure limit 0.2 mg(Pb)/m3, Skin, JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.05 mg(Pb)/m3, KZG-week 0.1 mg(Pb)/m3, skin, JAN2011 | |
Occupational Exposure Limit-THAILAND | time-weighted average 0.07 mg/m3, JAN1993 | |
Occupational Exposure Limit-THAILAND | time-weighted average 0.2 mg(Pb)/m3, JAN1993 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.05 mg/m3, Skin, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.07 mg/m3, Skin, JAN1993 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.15 mg(Pb)/m3, JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 0.2 mg(Pb)/m3, JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.15 mg(Pb)/m3 (skin) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.075 mg(Pb)/m3 | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.075 mg(Pb)/m3 (skin) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.15 mg(Pb)/m3 (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRAMETHYLLEAD-air | 10H time-weighted average 0.075 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 71860; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 7 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health