Plumbane, tetraethyl-

RTECS #

TP4550000

CAS #

78-00-2
See: NMAM or OSHA Methods

Updated

March 2018

Molecular Weight

323.47

Molecular Formula

C₈H₂₀Pb

Synonyms

Czteroetylek olowiu (Polish)
Lead, tetraethyl-
NCI-C54988
NSC 22314
Piombo tetra-etile (Italian)
RCRA waste number P110
TEL
Tetraethyl lead
Tetraethyl lead (ACGIH:OSHA)
Tetraethylolovo (Czech)
Tetraethylplumbane
Tetraethylplumbium

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
morphological transform	embryo/hamster	12500 µg/L	AETODY 1,241,1980

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	3 mg/kg (14D pregnant)	Reproductive: Effects on newborn: Biochemical and metabolic	BNEOBV 58,41,1990
intraperitoneal/rat	1499 µg/kg (13D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Hepatobiliary system	VHTODE 34,510,1992
intraperitoneal/rat	3 mg/kg (19D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Urogenital system	VHTODE 34,510,1992
oral/mouse	11 mg/kg (5-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	FCTXAV 13,629,1975
oral/rat	11 mg/kg (6-16D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	FCTXAV 13,629,1975
oral/rat	7500 µg/kg (12-14D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TXAPA9 21,265,1972

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
subcutaneous/mouse	lowest published toxic dose: 100 mg/kg/21D- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Blood: Lymphoma including Hodgkin's disease	EXPEAM 24,580,1968

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/human	lowest published toxic concentration: 1749 gm/m³/30M	Olfaction: Other olfaction effects Eye: Lacrimation Gastrointestinal: Nausea or vomiting	SAIGBL 17,223,1975
inhalation/mouse	Lowest published lethal concentration: 650 mg/m³/7H		SAIGBL 15,3,1973
inhalation/mouse	lethal concentration (50 percent kill): 48.52 mg/m³/2H		TPKVAL 9,7,1967
inhalation/mouse	lethal concentration (50 percent kill): 3.5 ppm/2H		TPKVAL 9,7,1967
inhalation/rat	lethal concentration (50 percent kill): 850 mg/m³/1H	Behavioral: Excitement Lung, Thorax, or Respiration: Cyanosis	BJIMAG 18,277,1961
intraperitoneal/rat	lethal dose (50 percent kill): 15 mg/kg		MELAAD 54,486,1963
intravenous/rabbit	lowest published lethal dose: 22 mg/kg		EQSSDX 1,1,1975
intravenous/rat	lethal dose (50 percent kill): 14400 µg/kg		MELAAD 54,486,1963
oral/rabbit	lowest published lethal dose: 30 mg/kg		SAIGBL 15,3,1973
oral/rat	lethal dose (50 percent kill): 12300 µg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Convulsions or effect on seizure threshold Behavioral: Aggression	EXPEAM 28,923,1972
parenteral/rat	lethal dose (50 percent kill): 15 mg/kg		AOHYA3 3,226,1961
skin/Dog	lowest published lethal dose: 547 mg/kg		SAIGBL 15,3,1973
skin/guinea pig	lowest published lethal dose: 995 mg/kg		SAIGBL 15,3,1973
skin/rabbit	lowest published lethal dose: 830 mg/kg		SAIGBL 15,3,1973
subcutaneous/mouse	lethal dose (50 percent kill): 13020 µg/kg	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Convulsions or effect on seizure threshold	FKIZA4 49,2779,1958
subcutaneous/rabbit	lowest published lethal dose: 32 mg/kg		EQSSDX 1,1,1975
unreported route/man	lowest published lethal dose: 1470 µg/kg		85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 1100 mg/m³/1H/5D- intermittent	Brain and Coverings: Other degenerative changes Behavioral: Convulsions or effect on seizure threshold Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0533656-1
intravenous/monkey	lowest published toxic dose: 42 mg/kg/7D- intermittent	Behavioral: Food intake (animal) Kidney, Ureter, and Bladder: Other changes in urine composition Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOLED5 2,187,1978
oral/mouse	lowest published toxic dose: 10 mg/kg/5D- intermittent	Behavioral: Tremor	NTPTR* NTR-IMM-20009
oral/mouse	lowest published toxic dose: 14 mg/kg/14D- intermittent	Blood: Normocytic anemia Blood: Luekopenia Blood: Changes in erythrocyte (RBC) count	NTPTR* IMM-20009
oral/mouse	lowest published toxic dose: 14 mg/kg/14D- intermittent	Liver: Hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, and Bladder: Renal function tests depressed Immunological Including Allergic: Decrease in cellular immune response	NTPTR* IMM-20009
oral/mouse	lowest published toxic dose: 14 mg/kg/14D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Immunological Including Allergic: Decreased immune response	NTPTR* IMM-20009
oral/rat	lowest published toxic dose: 2520 µg/kg/6W- continuous	Endocrine: Other changes	JANSY* 8,287,1983
skin/Dog	lowest published toxic dose: 504 µL/kg/21D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	FKIZA4 49,2779,1958

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 mg(Pb)/m3 (skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMSUDL 7,230,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 23,325,1980
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMSUDL 7,230,1987
TOXICOLOGY REVIEW		JORCAI 76,265,1974
TOXICOLOGY REVIEW		JAMAAP 105,578,1935
TOXICOLOGY REVIEW		FCTXAV 9,105,1971
TOXICOLOGY REVIEW		AJMEAZ 38,409,1965
TOXICOLOGY REVIEW		85DHAX Pb,255,1972
TOXICOLOGY REVIEW		IMEMDT 87,225,
TOXICOLOGY REVIEW		NCLNA* 16,503,1998
TOXICOLOGY REVIEW		NBREV* 26,81,2002
TOXICOLOGY REVIEW		MUREAV 762,76,2014
TOXICOLOGY REVIEW		MUREAV 770,119,2016

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.1 mg(Pb)/m³ (skin)	DTLVS* 3,251,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypt	time-weighted average 0.1 mg/m³, JAN1993
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 mg(Pb)/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.05 mg/m³;KZW 0.2 mg/m³, skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 mg(Pb)/m³, Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.007 ppm (0.05 mg(Pb)/m³), skin, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.075 mg(Pb)/m³, short term exposure limit 0.23 mg(Pb)/m³, skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.1 mg(Pb)/m³, Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.05 mg(Pb)/m³, skin, 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 0.05 mg/m³, short term exposure limit 0.2 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.05 mg/m³, skin, NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.075 mg(Pb)/m³, skin, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 0.075 mg/m³, skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.1 mg(Pb)/m³;short term exposure limit 0.3 mg(Pb)/m³ (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.1 mg(Pb)/m³, skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.001 ppm (0.075 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,1 mg/m³, JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 0.05 mg/m³, MAC(short term exposure limit) 0.1 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.005 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 0.05 mg(Pb)/m³;short term exposure limit 0.2 mg(Pb)/m³, Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.05 mg/m³, KZG-week 0.1 mg/m³, skin, JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 0.075 mg/m³, JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.05 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.075 mg/m³, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.1 mg(Pb)/m³ (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.075 mg(Pb)/m³	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.075 mg(Pb)/m³ (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.1 mg(Pb)/m³ (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRAETHYLLEAD (as Pb)-air	10H time-weighted average 0.075 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 71640; Number of Industries 6; Total Number of Facilities 729; Number of Occupations 15; Total Number of Employees Exposed 36802; Total Number of Female Employees Exposed 1099
National Occupational Hazard Survey 1974	Hazard Code 71640; Number of Industries 1; Total Number of Facilities 85; Number of Occupations 6; Total Number of Employees Exposed 799

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Tetraethyl lead (as Pb), 2533
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health