Piperazine, dihydrochloride
RTECS #
TL4025000
CAS #
Updated
September 2013
Molecular Weight
159.08
Molecular Formula
C4H10N2·2ClH
Synonyms
Diethylenediamine dihydrochloride
Dihydro Pip Wormer
Dihydrochloride salt of diethylenediamine
Dowzene DHC
Piperazine dihydrochloride (ACGIH)
Piperazine hydrochloride
Piperazine wormer premix
Dihydro Pip Wormer
Dihydrochloride salt of diethylenediamine
Dowzene DHC
Piperazine dihydrochloride (ACGIH)
Piperazine hydrochloride
Piperazine wormer premix
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/mouse | lethal dose (50 percent kill): 1970 mg/kg | Lung, Thorax, or Respiration: Respiratory stimulation | JJPAAZ 17,475,1967 |
| oral/rat | lethal dose (50 percent kill): 4900 mg/kg | GUCHAZ 6,416,1973 | |
| subcutaneous/mouse | lethal dose (50 percent kill): 2030 mg/kg | ARZNAD 4,649,1954 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.03 ppm (inhal, vapor) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 mg/m3, JUL2008 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 mg/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 mg/m3, MAY2011 | |
| Occupational Exposure Limit-FRANCE | VME 5 mg/m3, FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 mg/m3, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 mg/m3, 2006 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 mg/m3, JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 5 mg/m3, JUL2005 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 0.1 ppm (0.3 mg(C4H10N2)/m3);short term exposure limit 0.3 ppm (1 mg/m3), Sen, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 5 mg/m3, inhal, JAN2011 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3, sen, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | skin | CFRGBR 29,1926.55,1994 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PIPERAZINE-air | 10H time-weighted average 5.0 mg/m3 | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 80559; Number of Industries 1; Total Number of Facilities 163; Number of Occupations 12; Total Number of Employees Exposed 5730 | |
| National Occupational Hazard Survey 1974 | Hazard Code 80559; Number of Industries 1; Total Number of Facilities 68; Number of Occupations 5; Total Number of Employees Exposed 1284 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay | |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health