Picolinic acid, 4-amino-3,5,6-trichloro-
RTECS #
TJ7525000
CAS #
Updated
October 2017
Molecular Weight
241.46
Molecular Formula
C6H3Cl3N2O2
Synonyms
2-Pyridinecarboxylic acid, 4-amino-3,5,6-trichloro-
3,5,6-Trichloro-4-aminopicolinic acid
4-Amino-3,5,6-trichloro-2-picolinic acid
4-Amino-3,5,6-trichloropicolinic acid
4-Amino-3,5,6-trichlorpicolinsaeure (German)
Amdon
Amdon grazon
ATCP
Borolin
Grazon
K-Pin
NCI-C00237
Picloram
Picloram (ACGIH:OSHA)
Picloram, acid
Tordon
3,5,6-Trichloro-4-aminopicolinic acid
4-Amino-3,5,6-trichloro-2-picolinic acid
4-Amino-3,5,6-trichloropicolinic acid
4-Amino-3,5,6-trichlorpicolinsaeure (German)
Amdon
Amdon grazon
ATCP
Borolin
Grazon
K-Pin
NCI-C00237
Picloram
Picloram (ACGIH:OSHA)
Picloram, acid
Tordon
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
mutation in microorganisms | /Other microorganisms | 200 µg/plate (-enzymatic activation step) | MUREAV 57,277,1978 |
mutation in microorganisms | /Saccharomyes cerevisiae | 100 mg/L (-enzymatic activation step) | TGANAK 18,455,1984 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | 5 gm/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | FCTXAV 10,797,1972 |
oral/rat | 7500 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Urogenital system | FCTXAV 10,797,1972 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/mouse | lowest published toxic dose: 340 gm/kg/80W- continuous | Tumorigenic: Neoplastic by RTECS criteria Endocrine: Tumors Endocrine: Thyroid tumors | JTEHD6 7,207,1981 |
oral/rat | toxic dose: 208 gm/kg/80W- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors | NCITR* NCI-TR-23,1978 |
oral/rat | toxic dose: 416 gm/kg/80W- continuous | Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors Endocrine: Tumors | NCITR* NCI-TR-23,1978 |
oral/rat | toxic dose: 417 gm/kg/80W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Endocrine: Tumors Endocrine: Thyroid tumors | JTEHD6 7,207,1981 |
oral/rat | lowest published toxic dose: 208 mg/kg/80W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Endocrine: Tumors Endocrine: Thyroid tumors | JTEHD6 7,207,1981 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/duck | lethal dose (50 percent kill): >2 gm/kg | DOEAAH 35,25,1979 | |
oral/rabbit | lethal dose (50 percent kill): 2 gm/kg | GUCHAZ 6,414,1973 | |
oral/rat | lethal dose (50 percent kill): 4012 mg/kg | FEREAC 64,420,1999 | |
skin/rabbit | lethal dose (50 percent kill): >4 gm/kg | WRPCA2 9,119,1970 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/mouse | lowest published toxic dose: 2100 mg/kg/21D- intermittent | Liver: Changes in liver weight Endocrine: Changes in spleen weight | AECTCV 24,449,1993 |
oral/rat | lowest published toxic dose: 7 gm/kg/2W- continuous | Liver: Changes in liver weight | JTEHD6 20,367,1987 |
oral/rat | lowest published toxic dose: 27300 mg/kg/13W- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight | JTEHD6 20,367,1987 |
oral/rat | lowest published toxic dose: 10920 mg/kg/26W- continuous | Liver: Changes in liver weight | JTEHD6 20,367,1987 |
oral/rat | lowest published toxic dose: 73 gm/kg/1Y- continuous | Liver: Changes in liver weight | JTEHD6 20,367,1987 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 10 mg/m3 | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 53,481,1991 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Available Data | IMEMDT 53,481,1991 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 53,481,1991 |
TOXICOLOGY REVIEW | DTTIAF 80,485,1973 | |
TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
TOXICOLOGY REVIEW | ENTOX* -,436,2005 | |
TOXICOLOGY REVIEW | FEREAC 72,41913,2007 | |
TOXICOLOGY REVIEW | TXAPA9 268,157,2013 | |
TOXICOLOGY REVIEW | MUREAV 802,1,2016 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | RED Completed | RBREV* -,143,1998 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 mg/m3, JUL2008 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 10 mg/m3, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 10 mg/m3, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 10 mg/m3, FEB2006 | |
Occupational Exposure Limit-ICELAND | time-weighted average 10 mg/m3, NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 mg/m3, JAN2002 | |
Occupational Exposure Limit-PERU | time-weighted average 10 mg/m3, JUL2005 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 2 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 10 mg/m3, inhal, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 10 mg/m3, 2003 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1915.1000,1993 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NCI Carcinogenesis Bioassay (feed);equivocal evidence:rat | NCITR* NCI-TR-23,1978 |
NCI Carcinogenesis Bioassay (feed);no evidence:mouse | NCITR* NCI-TR-23,1978 |
On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health