Phosphorus chloride

RTECS #

TH3675000

CAS #

7719-12-2
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

137.32

Molecular Formula

Cl₃P

Synonyms

Fosforo(tricloruro di) (Italian)
Fosfortrichloride (Dutch)
Phosphine, trichloro-
Phosphore(trichlorure de) (French)
Phosphorous chloride
Phosphortrichlorid (German)
Phosphorus trichloride
Phosphorus trichloride (ACGIH:OSHA)
Trichlorophosphine
Trojchlorek fosforu (Polish)

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	lowest published toxic concentration: 40 mg/m³/6H	Lung, Thorax, or Respiration: Cough Eye: Conjunctiva irritation	VCVN5* -,71,1993
inhalation/cat	lowest published toxic concentration: 10 mg/m³/1H	Lung, Thorax, or Respiration: Respiratory depression	VCVN5* -,71,1993
inhalation/cat	Lowest published lethal concentration: 500 mg/m³		VCVN5* -,71,1993
inhalation/guinea pig	lethal concentration (50 percent kill): 50 ppm/4H	Eye: Other eye effects Behavioral: Irritability Lung, Thorax, or Respiration: Dyspnea	AIHAAP 25,470,1964
inhalation/guinea pig	lethal concentration (50 percent kill): 63.5 mg/m³		VCVN5* -,71,1993
inhalation/rabbit	Lowest published lethal concentration: 3500 mg/m³		VCVN5* -,71,1993
inhalation/rat	lowest published toxic concentration: 0.005 gm/m³	Skin: After systemic exposure: Dermatitis, irritative	TPKVAL 13,107,1973
inhalation/rat	Lowest published lethal concentration: 0.31 gm/m³		TPKVAL 13,107,1973
inhalation/rat	Lowest published lethal concentration: 0.14 gm/m³	Eye: Lacrimation Eye: Corneal damage Behavioral: Somnolence (general depressed activity)	TPKVAL 13,107,1973
inhalation/rat	lethal concentration (50 percent kill): 104 ppm/4H	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Other changes Blood: Hemorrhage	AIHAAP 25,470,1964
inhalation/rat	lethal concentration (50 percent kill): 132 mg/m³		VCVN5* -,71,1993
ocular/rabbit	lowest published toxic dose: 100 pph	Lung, Thorax, or Respiration: Respiratory stimulation	TPKVAL 13,107,1973
oral/mammal (species unspecified)	lethal dose (50 percent kill): 350 mg/kg		GISAAA 39(4),86,1974
oral/rat	lowest published lethal dose: 675 mg/kg		TPKVAL 13,107,1973
oral/rat	lethal dose (50 percent kill): 18 mg/kg	Behavioral: Food intake (animal) Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Gastrointestinal: Peritonitis	ATDAEI 1,71,1990
oral/rat	lethal dose (16 percent kill): 430 mg/kg	Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Ulceration or bleeding from stomach Liver: Other changes	TPKVAL 13,107,1973
oral/rat	lethal dose (50 percent kill): 550 mg/kg		TPKVAL 13,107,1973
skin/mouse	lowest published toxic dose: 100 pph/5M		TPKVAL 13,107,1973
skin/rabbit	lowest published lethal dose: 1260 mg/kg	Behavioral: Muscle weakness Liver: Change in gall bladder structure or function Blood: Other changes	ATDAEI 1,71,1990

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.2 ppm;short term exposure limit 0.5 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.5 ppm (3 mg/m³)	DTLVS* 3,211,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypt	time-weighted average 0.5 ppm (3 mg/m³), JAN1993
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.2 ppm (1.1 mg/m³), short term exposure limit 0.5 ppm (2.8 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.25 ppm (1.5 mg/m³);KZW 0.5 ppm (3 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.2 ppm(1.1 mg/m³), short term exposure limit 0.5 ppm(2.8 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.2 ppm (1.2 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	short term exposure limit 0.5 ppm (2.8 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 0.2 ppm (1.5 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.5 ppm (2.8 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 3 mg/m³, short term exposure limit 3 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.2 ppm (1.2 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.2 ppm (1.1 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 0.2 ppm (1.5 mg/m³), short term exposure limit 0.5 ppm (3 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.2 ppm (1.1 mg/m³), 2004
Occupational Exposure Limit-MEXICO	time-weighted average 0.5 ppm (2.8 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.2 ppm (1.1 mg/m³), short term exposure limit 0.5 ppm (2.8 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.2 ppm (1.5 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,2 ppm (1,1 mg/m³); short term exposure limit 0,5 ppm (2,8 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 3 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.2 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 0.2 ppm (1.2 mg/m³);short term exposure limit 0.4 ppm (2.4 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 0.25 ppm (1.5 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1.5 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.5 ppm (3 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.5 ppm (3 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 0.2 ppm (1.1 mg/m³);short term exposure limit 0.5 ppm (2.9 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.5 ppm (3 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.5 ppm (3 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.5 ppm (3 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.5 ppm (3 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHORUS TRICHLORIDE-air	10H time-weighted average 0.2 ppm;short term exposure limit 0.5 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 59166; Number of Industries 4; Total Number of Facilities 96; Number of Occupations 6; Total Number of Employees Exposed 2963; Total Number of Female Employees Exposed 329
National Occupational Hazard Survey 1974	Hazard Code 59166; Number of Industries 4; Total Number of Facilities 149; Number of Occupations 12; Total Number of Employees Exposed 2520

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phosphorus trichloride, 6402

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health