Phosphorous acid, trimethyl ester
RTECS #
TH1400000
CAS #
Updated
December 2017
Molecular Weight
124.09
Molecular Formula
C3H9O3P
Synonyms
Fosforyn trojmetylowy (Czech)
Trimethoxyfosfin (Czech)
Trimethoxyphosphine
Trimethyl phosphite
Trimethyl phosphite (ACGIH)
Trimethylfosfit (Czech)
Trimethoxyfosfin (Czech)
Trimethoxyphosphine
Trimethyl phosphite
Trimethyl phosphite (ACGIH)
Trimethylfosfit (Czech)
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /mammal (species unspecified) | 100 mg | mild | MEPAAX 29,393,1978 |
eye /rabbit | 0.1 mL | mild | HPV416 -,-,2005 |
skin /mammal (species unspecified) | 500 mg | mild | MEPAAX 29,393,1978 |
skin /rabbit | 500 mg | severe | 34ZIAG -,609,1969 |
skin /rabbit | 0.5 mL | mild | HPV416 -,-,2005 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
mutation in mammalian somatic cells | other cell types/mouse | 2.7 mL/L (+/-enzymatic activation step) | HPV416 ,,2005 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | 1640 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 72,119,1984 |
oral/rat | 1640 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Specific developmental abnormalities: Homeostasis | TXAPA9 72,119,1984 |
oral/rat | 1640 mg/kg (6-15D pregnant) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | HPV416 -,-,2005 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | lowest published toxic dose: 51500 mg/kg/103W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains | HPV416 -,-,2005 |
oral/rat | lowest published toxic dose: 103000 mg/kg/103W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Gastrointestinal: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains | HPV416 -,-,2005 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | Lethal concentration: >32700 mg/m3/6H | Eye: Lacrimation Eye: Ptosis Behavioral: Somnolence (general depressed activity) | NTIS** OTS0537047 |
inhalation/mouse | Lowest published lethal concentration: 32700 mg/m3/6H | Eye: Lacrimation Eye: Ptosis Behavioral: Somnolence (general depressed activity) | NTIS** OTS0537047 |
inhalation/rat | Lowest published lethal concentration: 32700 mg/m3/6H | Eye: Lacrimation Eye: Ptosis Behavioral: Somnolence (general depressed activity) | NTIS** OTS0537047 |
inhalation/rat | lethal concentration (50 percent kill): 182000 mg/m3/1H | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression | HPV416 -,-,2005 |
inhalation/rat | lethal concentration (50 percent kill): >9000 ppm/4H | HPV416 -,-,2005 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 4180 mg/kg | ENVRAL 9,1,1975 | |
oral/mouse | lethal dose (50 percent kill): 4280 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression | NTIS** OTS0540442 |
oral/rat | lethal dose (50 percent kill): 1350 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Ulceration or bleeding from stomach | HPV416 -,-,2005 |
oral/rat | lethal dose (50 percent kill): 1500 mg/kg | Gastrointestinal: Ulceration or bleeding from stomach Liver: Other changes Blood: Changes in spleen | HPV416 -,-,2005 |
oral/rat | lethal dose (50 percent kill): 1600 mg/kg | ALBRW* #OPB-3,1984 | |
skin/rabbit | lethal dose (50 percent kill): 933.8 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes Blood: Hemorrhage | HPV416 -,-,2005 |
skin/rabbit | lethal dose (50 percent kill): 2600 mg/kg | AIHAAP 34,286,1973 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 500 ppm/7.5H/8W- intermittent | Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Skin and Appendages: Other: Hair | AIHAAP 34,286,1973 |
inhalation/rat | lowest published toxic concentration: 292 ppm/4W- intermittent | Eye: Corneal damage Kidney, Ureter, and Bladder: Changes in kidney weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV416 -,-,2005 |
inhalation/rat | lowest published toxic concentration: 50 ppm/28D- intermittent | Eye: Corneal damage | HPV416 -,-,2005 |
inhalation/rat | lowest published toxic concentration: 500 ppm/8W- intermittent | Lung, Thorax, or Respiration: Emphysema Skin: After systemic exposure: Dermatitis, irritative | HPV416 -,-,2005 |
oral/rat | lowest published toxic dose: 689 mg/kg | Olfaction: Other olfaction effects Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Other changes | NTIS** OTS0540442 |
oral/rat | lowest published toxic dose: 3444 mg/kg/21D- intermittent | Lung, Thorax, or Respiration: Other changes Gastrointestinal: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV416 -,-,2005 |
oral/rat | lowest published toxic dose: 14400 mg/kg/90D- intermittent | Liver: Fatty liver degeneration Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV416 -,-,2005 |
skin/rabbit | lowest published toxic dose: 6300 mg/kg/21D- intermittent | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Liver: Hepatitis (hepatocellular necrosis), diffuse Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV416 -,-,2005 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2 ppm | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | MUREAV 741,32,2012 | |
TOXICOLOGY REVIEW | MUREAV 802,38,2016 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIMETHYL PHOSPHITE-air | 10H time-weighted average 2 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 84215; Number of Industries 2; Total Number of Facilities 55; Number of Occupations 18; Total Number of Employees Exposed 14190; Total Number of Female Employees Exposed 6312 | |
National Occupational Hazard Survey 1974 | Hazard Code 84215; Number of Industries 5; Total Number of Facilities 260; Number of Occupations 7; Total Number of Employees Exposed 1891 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8977;8EHQ-0892-8988 | |
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9122 | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health