Phosphorothioic acid, O,O-diethyl O-(p-(methylsulfinyl)phenyl) ester

RTECS #

TF3850000

CAS #

115-90-2
See: NMAM or OSHA Methods

Updated

December 2015

Molecular Weight

308.37

Molecular Formula

C₁₁H₁₇O₄PS₂

Synonyms

BAY 25141
Bayer 25141
Chemagro 25141
Daconit
Dasanit
ENT 24,945
Fensulfothion
Fensulfothion (ACGIH)
O,O-Diaethyl-O-(4-methylsulfinyl-phenyl)-thionophosphat (German)
O,O-Diaethyl-O-4-methylsulfinyl-phenyl-monothiophosphat (German)
O,O-Diethyl O-(p-(methylsulfinyl)phenyl) phosphorothioate
O,O-Diethyl O-p-(methylsulfinyl)phenyl thiophosphate
OMS 37
Phenol, p-(methylsulfinyl)-, O-ester with O,O-diethyl phosphorothioate
S 767
Terracur P
VUAgT 108
VUAgT 96

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lethal concentration (50 percent kill): 113 mg/m³/1H		85JFAN A202,1983
intracerebral/mouse	lethal dose (50 percent kill): 2 mg/kg		PCBPBS 8,302,1978
intraperitoneal/guinea pig	lethal dose (50 percent kill): 5400 µg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 6,78,1964
intraperitoneal/mouse	lethal dose (50 percent kill): 7 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 6,78,1964
intraperitoneal/rat	lethal dose (50 percent kill): 1500 µg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 6,78,1964
oral/duck	lethal dose (50 percent kill): 747 µg/kg		TXAPA9 22,556,1972
oral/guinea pig	lethal dose (50 percent kill): 9 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 6,78,1964
oral/pigeon	lethal dose (50 percent kill): 560 µg/kg		ASTTA8 (680),157,1979
oral/quail	lethal dose (50 percent kill): 1200 µg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	EESADV 8,551,1984
oral/rat	lethal dose (50 percent kill): 2200 µg/kg		TXAPA9 6,78,1964
oral/wild bird	lethal dose (50 percent kill): 240 µg/kg		TXAPA9 21,315,1972
skin/duck	lethal dose (50 percent kill): 3 mg/kg		TXAPA9 47,451,1979
skin/rat	lethal dose (50 percent kill): 3 mg/kg		WRPCA2 9,119,1970
skin/wild bird	lethal dose (50 percent kill): 420 µg/kg		TXAPA9 26,154,1973
unreported route/rat	lethal dose (50 percent kill): 11 mg/kg		30ZDA9 -,337,1971

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	lowest published toxic dose: 30 mg/kg/60D- continuous	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXAPA9 6,78,1964

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.01 mg/m³ (inhal, vapor, skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		RREVAH 63,1,1976
TOXICOLOGY REVIEW		TOLED5 230,434,2014

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,120,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.1 mg/m³;KZW 0.2 mg/m³, skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.01 mg/m³, Skin, MAR2002
Occupational Exposure Limit-FRANCE	VME 0.1 mg/m³, FEB2006
Occupational Exposure Limit-KOREA	time-weighted average 0.1 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.1 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.1 mg/m³, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0,1 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.1 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.1 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FENSULFOTHION-air	10H time-weighted average 0.1 mg/m³	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health