Phosphorothioic acid, O,O-diethyl O-(2-(ethylthio)ethyl) ester, mixed with O,O-diethyl S-(2-(ethylthio)ethyl) phosphorothioate (7:3)
RTECS #
TF3150000
CAS #
Updated
September 2013
Molecular Weight
516.72
Molecular Formula
C8H19O3PS2·C8H19O3PS2
Synonyms
Bayer 8169
Demeton
Demeton (ACGIH:OSHA)
Diethoxy thiophosphoric acid ester of 2-ethylmercaptoethanol
E 1059
ENT 17,295
Ethyl systox
Mercaptofos
Mercaptophos
O,O-Diethyl 2-ethylmercaptoethyl thiophosphate
O,O-Diethyl O(and S)-2-(ethylthio)ethyl phosphorothioate mixture
Septox
Systox
Systox (OSHA)
Demeton
Demeton (ACGIH:OSHA)
Diethoxy thiophosphoric acid ester of 2-ethylmercaptoethanol
E 1059
ENT 17,295
Ethyl systox
Mercaptofos
Mercaptophos
O,O-Diethyl 2-ethylmercaptoethyl thiophosphate
O,O-Diethyl O(and S)-2-(ethylthio)ethyl phosphorothioate mixture
Septox
Systox
Systox (OSHA)
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 500 ppm | NTIS** PB84-138973 |
mutation in mammalian somatic cells | lymphocyte/mouse | 80 mg/L | NTIS** PB84-138973 |
mutation in microorganisms | /Saccharomyes cerevisiae | 500 ppm (+/-enzymatic activation step) | NTIS** PB84-138973 |
sister chromatid exchange | ovary/hamster | 25 ppm | NTIS** PB84-138973 |
sister chromatid exchange | lung/hamster | 10 mg/L | MUREAV 88,307,1981 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/mouse | 10 mg/kg (11D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Gastrointestinal system Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TXAPA9 24,324,1973 |
parenteral/mouse | 10 mg/kg (7D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | ANREAK 169,285,1971 |
parenteral/mouse | 7 mg/kg (11D pregnant) | Reproductive: Specific developmental abnormalities: Gastrointestinal system | ANREAK 169,285,1971 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/cat | Lowest published lethal concentration: 15 mg/m3/4H | 85GMAT -,52,1982 | |
inhalation/mouse | lethal concentration (50 percent kill): 0.01 gm/m3/2H | TPKVAL 9,7,1967 | |
inhalation/mouse | lethal concentration (50 percent kill): 0.96 ppm/2H | TPKVAL 9,7,1967 | |
inhalation/rat | Lowest published lethal concentration: 15 mg/m3/4H | 85GMAT -,52,1982 | |
intramuscular/cat | lethal dose (50 percent kill): 3900 µg/kg | Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Nausea or vomiting | 13ZGAF -,220,1962 |
intramuscular/Dog | lethal dose (50 percent kill): 3650 µg/kg | Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Nausea or vomiting | 13ZGAF -,220,1962 |
intramuscular/rat | lowest published lethal dose: 3 mg/kg | Behavioral: Tremor Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Nausea or vomiting | 13ZGAF -,220,1962 |
intraperitoneal/mouse | lethal dose (50 percent kill): 4 mg/kg | PSEBAA 129,699,1968 | |
intraperitoneal/rabbit | lethal dose (50 percent kill): 3250 µg/kg | BLLIAX 38,151,1958 | |
intraperitoneal/rat | lethal dose (50 percent kill): 2500 µg/kg | APCRAW 4,117,1961 | |
intravenous/mouse | lethal dose (50 percent kill): 3900 µg/kg | BLLIAX 38,151,1958 | |
intravenous/rat | lethal dose (50 percent kill): 1750 µg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Gastrointestinal: Hypermotility, diarrhea | BLLIAX 38,151,1958 |
oral/duck | lethal dose (50 percent kill): 7190 µg/kg | TXAPA9 47,451,1979 | |
oral/human | lowest published lethal dose: 171 µg/kg | CMEP** -,1,1956 | |
oral/man | lowest published toxic dose: 144 mg/kg/24D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 14,603,1969 |
oral/mouse | lethal dose (50 percent kill): 7850 µg/kg | BLLIAX 38,151,1958 | |
oral/pigeon | lethal dose (50 percent kill): 8480 µg/kg | TXAPA9 20,57,1971 | |
oral/quail | lethal dose (50 percent kill): 8480 µg/kg | TXAPA9 20,57,1971 | |
oral/rabbit | lethal dose (50 percent kill): 5 mg/kg | GISAAA 27(8),97,1962 | |
oral/rat | lethal dose (50 percent kill): 1700 µg/kg | TXAPA9 21,315,1972 | |
oral/wild bird | lethal dose (50 percent kill): 1780 µg/kg | ASTTA8 (680),157,1979 | |
skin/rabbit | lethal dose (50 percent kill): 24 mg/kg | SPEADM 78-1,28,1978 | |
skin/rat | lethal dose (50 percent kill): 8200 µg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement | TXAPA9 2,88,1960 |
skin/wild bird | lethal dose (50 percent kill): 1800 µg/kg | TXAPA9 26,154,1973 | |
subcutaneous/mouse | lethal dose (50 percent kill): 15 mg/kg | APFRAD 11,286,1953 | |
subcutaneous/rabbit | lethal dose (50 percent kill): 24 mg/kg | IAEC** 17JUN1974 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/Dog | lowest published toxic dose: 7.9 mg/kg/168D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 1,59,2001 |
oral/human | lowest published toxic dose: 1.2 mg/kg/24D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 1,59,2001 |
oral/rat | lowest published toxic dose: 15.68 mg/kg/112D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 1,59,2001 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.05 mg/m3 (inhal, vapor, skin) | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | AQMOAC #73-19,1973 | |
TOXICOLOGY REVIEW | RREVAH 46,1,1973 | |
TOXICOLOGY REVIEW | CNDQA8 10(3),43,1975 | |
TOXICOLOGY REVIEW | DTTIAF 80,485,1973 | |
TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
TOXICOLOGY REVIEW | TOLED5 190,107,2009 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,109,1998 |
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.01 ppm (0.1 mg/m3) (skin) | DTLWS* 3,15,1973 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.01 ppm (0.11 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.01 ppm (0.1 mg/m3);KZW 0.1 ppm (1 mg/m3), skin, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.05 mg/m3 (vapor, aerosol), Skin, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.01 ppm (0.1 mg/m3), skin, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, skin, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 0.01 ppm (0.1 mg/m3), Skin, FEB2006 | |
Occupational Exposure Limit-ICELAND | time-weighted average 0.01 ppm (0.1 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-INDIA | time-weighted average 0.01 ppm (0.1 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit-KOREA | time-weighted average 0.01 ppm (0.1 mg/m3), skin, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 0.01 ppm (0.1 mg/m3);short term exposure limit 0.03 ppm (skin), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.01 ppm (0.11 mg/m3), skin, JAN2002 | |
Occupational Exposure Limit-PERU | time-weighted average 0.005 ppm (0.05 mg/m3), JUL2005 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 0.02 mg/m3, Skin, JUN2003 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.01 ppm (0.1 mg/m3), skin, JAN2011 | |
Occupational Exposure Limit-THAILAND | time-weighted average 0.1 mg/m3, JAN1993 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.1 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.1 mg/m3, Skin, JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 0.1 mg/m3, Skin, JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.1 mg/m3 (skin) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.1 mg/m3 (skin) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.1 mg/m3 (skin) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.1 mg/m3 (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DEMETON-air | 10H time-weighted average 0.1 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health