Phosphorodithioic acid, S,S'-p-dioxane-2,3-diyl O,O,O',O'-tetraethyl ester
RTECS #
TE3350000
CAS #
Updated
June 2017
Molecular Weight
456.56
Molecular Formula
C12H26O6P2S4
Synonyms
1,4-Diossan-2,3-diyl-bis(O,O-dietil-ditiofosfato) (Italian)
1,4-Dioxaan-2,3-diyl-bis(O,O-diethyl-dithiofosfaat) (Dutch)
1,4-Dioxan-2,3-diyl bis(O,O-diethylphosphorothiolothionate)
1,4-Dioxan-2,3-diyl O,O,O',O'-tetraethyl di(phosphoromithioate)
1,4-Dioxan-2,3-diyl-bis(O,O-diaethyl-dithiophosphat) (German)
2,3-p-Dioxandithiol S,S-bis(O,O-diethyl phosphorodithioate)
2,3-p-Dioxane S,S-bis(O,O-diethylphosphorodithioate)
2,3-P-Dioxan-S,S'-bis(O,O-diaethyldithiophosphat) (German)
AC 528
Bis(dithiophosphate de O,O-diethyle) de S,S'-(1,4-dioxanne-2,3-diyle) (French)
Delnatex
Delnav
Deltic
Dioxane phosphate
Dioxathion
Dioxathion (ACGIH)
Dioxation
Dioxothion
ENT 22,897
Hercules 528
Hercules AC528
Kavadel
Navadel
NCI-C00395
p-Dioxane-2,3-dithiol, S,S-diester with O,O-diethyl phosphorodithioate
p-Dioxane-2,3-diyl ethyl phosphorodithioate
Phosphorodithioic acid, S,S'-1,4-dioxane-2,3-diyl O,O,O',O'-tetraethyl ester (9CI)
Ruphos
1,4-Dioxaan-2,3-diyl-bis(O,O-diethyl-dithiofosfaat) (Dutch)
1,4-Dioxan-2,3-diyl bis(O,O-diethylphosphorothiolothionate)
1,4-Dioxan-2,3-diyl O,O,O',O'-tetraethyl di(phosphoromithioate)
1,4-Dioxan-2,3-diyl-bis(O,O-diaethyl-dithiophosphat) (German)
2,3-p-Dioxandithiol S,S-bis(O,O-diethyl phosphorodithioate)
2,3-p-Dioxane S,S-bis(O,O-diethylphosphorodithioate)
2,3-P-Dioxan-S,S'-bis(O,O-diaethyldithiophosphat) (German)
AC 528
Bis(dithiophosphate de O,O-diethyle) de S,S'-(1,4-dioxanne-2,3-diyle) (French)
Delnatex
Delnav
Deltic
Dioxane phosphate
Dioxathion
Dioxathion (ACGIH)
Dioxation
Dioxothion
ENT 22,897
Hercules 528
Hercules AC528
Kavadel
Navadel
NCI-C00395
p-Dioxane-2,3-dithiol, S,S-diester with O,O-diethyl phosphorodithioate
p-Dioxane-2,3-diyl ethyl phosphorodithioate
Phosphorodithioic acid, S,S'-1,4-dioxane-2,3-diyl O,O,O',O'-tetraethyl ester (9CI)
Ruphos
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| mutation in microorganisms | /Salmonella typhimurium | 6667 µg/plate (+enzymatic activation step) | ENMUDM 8(Suppl 7),1,1986 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lethal concentration (50 percent kill): 340 mg/m3/1H | Eye: Lacrimation Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Hypermotility, diarrhea | TXAPA9 5,605,1963 |
| inhalation/rat | lethal concentration (50 percent kill): 1398 mg/m3/1H | Eye: Lacrimation Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Hypermotility, diarrhea | TXAPA9 5,605,1963 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 33 mg/kg | PSEBAA 129,699,1968 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 30 mg/kg | Eye: Lacrimation Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Hypermotility, diarrhea | TXAPA9 5,605,1963 |
| oral/chicken | lethal dose (50 percent kill): >316 mg/kg | Eye: Lacrimation Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands | TXAPA9 5,605,1963 |
| oral/Dog | lethal dose (50 percent kill): 10 mg/kg | PCOC** -,427,1966 | |
| oral/human | lowest published toxic dose: 9 mg/kg/60D | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | 34ZIAG -,200,1969 |
| oral/mouse | lethal dose (50 percent kill): 176 mg/kg | Eye: Lacrimation Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Hypermotility, diarrhea | TXAPA9 5,605,1963 |
| oral/rat | lethal dose (50 percent kill): 20 mg/kg | WRPCA2 9,119,1970 | |
| skin/rabbit | lethal dose (50 percent kill): 85 mg/kg | PCOC** -,427,1966 | |
| skin/rat | lethal dose (50 percent kill): 63 mg/kg | Eye: Lacrimation Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Hypermotility, diarrhea | TXAPA9 5,605,1963 |
| subcutaneous/chicken | lethal dose (50 percent kill): >200 mg/kg | Eye: Lacrimation Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Hypermotility, diarrhea | TXAPA9 5,605,1963 |
| subcutaneous/rat | lethal dose (50 percent kill): 95 mg/kg | JEENAI 52,20,1959 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/Dog | lowest published toxic dose: 9600 µg/kg/12D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 5,605,1963 |
| oral/human | lowest published toxic dose: 4.2 mg/kg/28D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 1,59,2001 |
| oral/rat | lowest published toxic dose: 70980 µg/kg/13W- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 5,605,1963 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 mg/m3 (inhal, vapor, skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | MUREAV 802,1,2016 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,114,1998 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.2 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.2 mg/m3;KZW 0.4 mg/m3, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 mg/m3 (vapor, aerosol), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.2 mg/m3, skin, MAY2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.2 mg/m3, Skin, FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.2 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.2 mg/m3, skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.2 mg/m3 (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.2 mg/m3, skin, JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 0,1 mg/m3, JUL2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.2 mg/m3, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.2 mg/m3, Skin, 2003 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIOXATHION-air | 10H time-weighted average 0.2 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat | NCITR* NCI-TR-125,1978 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health