Phosphorodithioic acid, O,O-diethyl S-(2-(ethylthio)ethyl) ester

RTECS #

TD9275000

CAS #

298-04-4
See: NMAM or OSHA Methods

Updated

December 2016

Molecular Weight

274.42

Molecular Formula

C₈H₁₉O₂PS₃

Synonyms

BAY 19639
Bayer 19639
Disulfoton
Disulfoton (ACGIH)
Di-syston
Dithiodemeton
Dithiophosphate de O,O-diethyle et de S-(2-ethylthio-ethyle) (French)
Dithiosystox
Dution
Ekatin TD
ENT 23,437
Ethyl thiometon
Ethylthiometon B
Frumin AL
Frumin G
Glebofos
M-74
M-74 (Pesticide)
O,O-Diaethyl-S-(2-aethylthio-aethyl)-dithiophosphat (German)
O,O-Diaethyl-S-(3-thia-pentyl)-dithiophosphat (German)
O,O-Diethyl 2-ethylthioethyl phosphorodithioate
O,O-Diethyl S-(2-eththioethyl) phosphorodithioate
O,O-Diethyl S-(2-eththioethyl) thiothionophosphate
O,O-Diethyl S-(2-ethylmercaptoethyl) dithiophosphate
O,O-Diethyl S-2-(ethylthio)ethyl phosphorodithioate
O,O-Diethyl-S-(2-ethylthio-ethyl)-dithiofosfaat (Dutch)
O,O-Dietil-S-(2-etiltio-etil)-ditiofosfato (Italian)
O,O-Ethyl S-2(ethylthio)ethyl phosphorodithioate
Phosphorodithionic acid, S-2-(ethylthio)ethyl-O,O-diethyl ester
RCRA waste number P039
S-(2-(Ethylthio)ethyl)phosphorothionate
S-2-(Ethylthio)ethyl O,O-diethyl ester of phosphorodithioic acid
Solvirex
Thiodemeton
Vuagt 1-4
Vuagt 1964

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in mammalian somatic cells	lymphocyte/mouse	40 mg/L	NTIS** PB84-138973
mutation in microorganisms	/Salmonella typhimurium	5720 µg/plate (+enzymatic activation step)	MUREAV 28,405,1975
mutation in microorganisms	/Salmonella typhimurium	5 mg/plate (-enzymatic activation step)	MUREAV 116,185,1983
mutation in microorganisms	/Escherichia coli	5720 µg/plate (-enzymatic activation step)	MUREAV 28,405,1975
Unscheduled DNA Synthesis	fibroblast/human	1 gm/L	NTIS** PB80-133226

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	Lowest published lethal concentration: 10 mg/m³/4H	Behavioral: Tremor Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea	GTPZAB 4(9),21,1960
inhalation/rat	lethal concentration (50 percent kill): 200 mg/m³		85GYAV -,25,1971
inhalation/rat	lethal concentration (50 percent kill): 180 ppb/1H		ENTOX* -,85,2005
inhalation/rat	lethal concentration (50 percent kill): 90 mg/m³/1H		ENTOX* -,85,2005
intraperitoneal/guinea pig	lethal dose (50 percent kill): 7 mg/kg	Peripheral Nerve and Sensation: Fasciculations Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased	AMIHAB 17,192,1958
intraperitoneal/mouse	lethal dose (50 percent kill): 5500 µg/kg	Peripheral Nerve and Sensation: Fasciculations Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased	AMIHAB 17,192,1958
intraperitoneal/rat	lethal dose (50 percent kill): 2 mg/kg	Peripheral Nerve and Sensation: Fasciculations Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased	AMIHAB 17,192,1958
intravenous/rat	lethal dose (50 percent kill): 5500 µg/kg	Eye: Lacrimation Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement	13ZGAF -,206,1962
oral/Dog	lethal dose (50 percent kill): 5 mg/kg		PEMNDP 9,318,1991
oral/duck	lethal dose (50 percent kill): 6500 µg/kg		DOEAAH 35,25,1979
oral/guinea pig	lethal dose (50 percent kill): 10800 µg/kg	Peripheral Nerve and Sensation: Fasciculations Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased	AMIHAB 17,192,1958
oral/mouse	lethal dose (50 percent kill): 4800 µg/kg	Behavioral: Tremor Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea	GTPZAB 4(9),21,1960
oral/quail	lethal dose (50 percent kill): 12 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	EESADV 8,551,1984
oral/rat	lethal dose (50 percent kill): 2600 µg/kg		YKYUA6 37,717,1986
oral/wild bird	lethal dose (50 percent kill): 2400 µg/kg		TXAPA9 21,315,1972
oral/woman	lowest published toxic dose: 800 µg/kg	Behavioral: Hallucinations, distorted perceptions Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Other changes	JJTOEX 8,69,1995
skin/mouse	lethal dose (50 percent kill): 15600 µg/kg		YKYUA6 37,717,1986
skin/rabbit	lowest published lethal dose: 5 mg/kg		GTPZAB 2(5),7,1958
skin/rat	lethal dose (50 percent kill): 3.6 mg/kg		ENTOX* -,85,2005
unreported route/chicken	lethal dose (50 percent kill): 28 mg/kg		FMCHA2 -,C113,1991
unreported route/mouse	lethal dose (50 percent kill): 4600 µg/kg		GTPZAB 7(5),38,1963
unreported route/rat	lethal dose (50 percent kill): 2500 µg/kg		30ZDA9 -,369,1971

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/mouse	lowest published toxic dose: 140 mg/kg/14D- intermittent	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 65,457,1982
intraperitoneal/rat	lowest published toxic dose: 60 mg/kg/60D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHAB 17,192,1958
intraperitoneal/rat	lowest published toxic dose: 60 mg/kg/30D- intermittent	Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	FAATDF 20,163,1993
intraperitoneal/rat	lowest published toxic dose: 28 mg/kg/14D- intermittent	Brain and Coverings: Other degenerative changes Behavioral: Alteration of operant conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TOLED5 40,47,1988
oral/Dog	lowest published toxic dose: 36500 µg/kg/1Y- intermittent	Brain and Coverings: Other degenerative changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TOXID9 42,154,1998
oral/rat	lowest published toxic dose: 5460 µg/kg/13W- continuous	Brain and Coverings: Other degenerative changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	FAATDF 35,101,1997
oral/rat	lowest published toxic dose: 352 mg/kg/20W- continuous	Brain and Coverings: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Metabolism (intermediary): Other	ANYAA9 160,378,1969
oral/rat	lowest published toxic dose: 61 mg/kg/9W- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	GTPZAB 4(9),21,1960
unreported route/rat	lowest published toxic dose: 28 mg/kg/14D- intermittent	Brain and Coverings: Other degenerative changes	HBPTO* 2,1026,2001

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.05 mg/m³ (inhal, vapor, skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		AQMOAC #73-19,1973
TOXICOLOGY REVIEW		MZUZA8 (8),90,1973
TOXICOLOGY REVIEW		DTTIAF 80,485,1973
TOXICOLOGY REVIEW		RREVAH 63,1,1976
TOXICOLOGY REVIEW		ENTOX* -,85,2005
TOXICOLOGY REVIEW		FEREAC 73,31788,2008
TOXICOLOGY REVIEW		FEREAC 73,80317,2008
TOXICOLOGY REVIEW		HETOEA 26,321,2007
TOXICOLOGY REVIEW		FEREAC 74,46689,2009
TOXICOLOGY REVIEW		NBREV* 9,479,1985
TOXICOLOGY REVIEW		MUREAV 760,1,2014
TOXICOLOGY REVIEW		MUREAV 752,67,2013
TOXICOLOGY REVIEW		NRTXDN 39,158,2013
TOXICOLOGY REVIEW		TXAPA9 268,157,2013

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,115,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.1 mg/m³;KZW 0.2 mg/m³, skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 mg/m³, Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.1 mg/m³, skin, MAY2011
Occupational Exposure Limit-FRANCE	VME 0.1 mg/m³, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.1 mg/m³, skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.1 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.1 mg/m³;short term exposure limit 0.3 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.1 mg/m³, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.1 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,05 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.1 mg/m³, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.1 mg/m³, Skin, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DISULFOTON-air	10H time-weighted average 0.1 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	Hazard Code T0249; Number of Industries 2; Total Number of Facilities 92; Number of Occupations 2; Total Number of Employees Exposed 165

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264347)
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Weakly Positive: In vitro UDS-human fibroblast
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health