Phosphoric acid, triphenyl ester
RTECS #
TC8400000
CAS #
Updated
June 2018
Molecular Weight
326.30
Molecular Formula
C18H15O4P
Synonyms
Celluflex TPP
Disflamoll TP
Phosflex TPP
Reolube TPP
Reomol TPP
TPP
Trifenylfosfat (Czech)
Triphenyl phosphate
Triphenyl phosphate (ACGIH:OSHA)
Disflamoll TP
Phosflex TPP
Reolube TPP
Reomol TPP
TPP
Trifenylfosfat (Czech)
Triphenyl phosphate
Triphenyl phosphate (ACGIH:OSHA)
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/gtd | Inhibitor Concentration Low: 1 µmol/L | In Vitro Toxicity Studies: Membrane currents | TOLED5 213,266,2012 |
In Vitro/gtd | Inhibitor Concentration (50 percent kill): 7.9 µmol/L | In Vitro Toxicity Studies: Membrane currents | TOLED5 213,266,2012 |
In Vitro/Hamster, ovary | Inhibitor Concentration (50 percent kill): 37 µmol/L/24H | In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM) | TOLED5 227,93,2014 |
In Vitro/Hamster, ovary | Inhibitor Concentration (20 percent kill): 4.9 µmol/L/24H | Endocrine: Estrogenic | TXCYAC 314,76,2013 |
In Vitro/Hamster, ovary | Inhibitor Concentration (20 percent kill): 15 µmol/L/24H | Endocrine: Other changes | TXCYAC 314,76,2013 |
In Vitro/Human, liver | Inhibitor Concentration Low: 100 µmol/L/24H | Biochemical: Metabolism (intermediary): Other proteins | TOLED5 232,533,2015 |
In Vitro/Human, liver tumor | Inhibitor Concentration (10 percent kill): 44.3 µmol/L/72H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 29,2045,2015 |
In Vitro/Human, liver tumor | Inhibitor Concentration Low: 44.3 µmol/L/72H | In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc. | TIVIEQ 29,2045,2015 |
In Vitro/jrd | Inhibitor Concentration Low: 1000 µmol/L/24H | In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. | TIVIEQ 33,153,2016 |
In Vitro/jrd | Inhibitor Concentration (20 percent kill): 88.0 µmol/L/24H | Endocrine: Estrogenic | TIVIEQ 33,153,2016 |
In Vitro/jvx | Inhibitor Concentration Low: 30 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 227,93,2014 |
In Vitro/Mouse, fibroblast | Inhibitor Concentration Low: >50 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay | TIVIEQ 40,280,2017 |
In Vitro/Mouse, fibroblast | Inhibitor Concentration Low: 0.1 µmol/L/48H | Endocrine: Other changes | TIVIEQ 40,280,2017 |
In Vitro/Mouse, fibroblast | Inhibitor Concentration Low: 0.01 µmol/L/48H | Biochemical: Metabolism (intermediary): Lipids including transport | TIVIEQ 40,280,2017 |
In Vitro/Mouse, fibroblast | Inhibitor Concentration Low: 10 µmol/L/8D | In Vitro Toxicity Studies: Cell differentiation | TIVIEQ 40,280,2017 |
inhalation/mammal (species unspecified) | lethal concentration (50 percent kill): 4200 mg/m3 | Olfaction: Other olfaction effects Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) | GISAAA 39(8),98,1974 |
intramuscular/rabbit | Lethal dose: >1 gm/kg | NIHBAZ 160,1,1932 | |
intraperitoneal/cat | Lethal dose: >400 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Somnolence (general depressed activity) Behavioral: Muscle weakness | AEHLAU 1,33,1960 |
intraperitoneal/mouse | lethal dose (50 percent kill): 1273 mg/kg | ABCHA6 31,1288,1967 | |
intraperitoneal/rat | Lethal dose: >5 gm/kg | Gastrointestinal: Other changes Skin and Appendages: Other: Hair | NTIS** OTS0535042 |
oral/cat | lowest published lethal dose: 2 gm/kg | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Tremor Behavioral: Muscle weakness | ARZNAD 7,585,1957 |
oral/chicken | lowest published lethal dose: 5 gm/kg | Spinal Cord: Other degenerative changes | NTIS** OTS0539872 |
oral/guinea pig | Lethal dose: >4 gm/kg | AEHLAU 1,33,1960 | |
oral/mouse | lethal dose (50 percent kill): 1320 mg/kg | Olfaction: Other olfaction effects Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) | GISAAA 39(8),98,1974 |
oral/rabbit | lowest published lethal dose: 3 gm/kg | AEHLAU 1,33,1960 | |
oral/rat | lethal dose (50 percent kill): 3500 mg/kg | Behavioral: Tremor Behavioral: Ataxia Gastrointestinal: Hypermotility, diarrhea | ARZNAD 7,585,1957 |
skin/guinea pig | lethal dose (50 percent kill): >4 gm/kg | KODAK* 21MAY1971 | |
skin/rabbit | lethal dose (50 percent kill): >7900 mg/kg | TXAPA9 41,291,1977 | |
subcutaneous/cat | lowest published lethal dose: 300 mg/kg | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Tremor Behavioral: Muscle weakness | NIHBAZ 160,1,1932 |
subcutaneous/guinea pig | Lethal dose: >3 gm/kg | AEHLAU 1,33,1960 | |
subcutaneous/monkey | lowest published lethal dose: 500 mg/kg | DTLVS* 4,420,1980 | |
subcutaneous/mouse | Lethal dose: >3 gm/kg | AEHLAU 1,33,1960 | |
subcutaneous/rabbit | lowest published lethal dose: 1 gm/kg | AEHLAU 1,33,1960 | |
subcutaneous/rat | Lethal dose: >3 gm/kg | AEHLAU 1,33,1960 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/cat | lowest published toxic dose: 600 mg/kg/10D- intermittent | Behavioral: Tremor Nutritional and Gross Metabolic: Other changes | ARZNAD 7,585,1957 |
oral/chicken | lowest published toxic dose: 25 gm/kg/5D- intermittent | Spinal Cord: Other degenerative changes Behavioral: Ataxia | NTIS** OTS0539873 |
oral/rat | lowest published toxic dose: 65 gm/kg/65D- continuous | Spinal Cord: Other degenerative changes Peripheral Nerve and Sensation: Sensory syndrome diagnostic of central lesion Nutritional and Gross Metabolic: Weight loss or decreased weight gain | ARZNAD 7,585,1957 |
oral/rat | lowest published toxic dose: 59353 mg/kg/35D- continuous | Liver: Changes in liver weight | AEHLAU 1,33,1960 |
skin/domestic bird | lowest published toxic dose: 1200 mg/kg/3D- intermittent | Spinal Cord: Other degenerative changes Behavioral: Ataxia | NEZAAQ 52,281,1997 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 3 mg/m3 | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | CRTXB2 3,289,1975 | |
TOXICOLOGY REVIEW | TXCYAC 313,94,2013 | |
TOXICOLOGY REVIEW | NETEEC 52,248,2015 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 3 mg/m3 | DTLVS* 3,272,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 3 mg/m3, JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 3 mg/m3;KZW 6 mg/m3, inhal, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 3 mg/m3, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 3 mg/m3, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 3 mg/m3, short term exposure limit 6 mg/m3, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 3 mg/m3, FEB2006 | |
Occupational Exposure Limit-ICELAND | time-weighted average 3 mg/m3, NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 3 mg/m3, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 3 mg/m3;short term exposure limit 6 mg/m3, 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 3 mg/m3, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 3 mg/m3, JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 3 mg/m3, JUL2005 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 1 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 3 mg/m3, inhal, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 3 mg/m3, 2003 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 3 mg/m3;short term exposure limit 6 mg/m3, OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 3 mg/m3 | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 3 mg/m3 | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 3 mg/m3 | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 3 mg/m3 | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIPHENYL PHOSPHATE-air | 10H time-weighted average 3 mg/m3 | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 74635; Number of Industries 51; Total Number of Facilities 2869; Number of Occupations 54; Total Number of Employees Exposed 91754; Total Number of Female Employees Exposed 22800 | |
National Occupational Hazard Survey 1974 | Hazard Code 74635; Number of Industries 11; Total Number of Facilities 341; Number of Occupations 30; Total Number of Employees Exposed 7631 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9169;8EHQ-0892-8839 | |
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9290 | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH Analytical Method, 1994: Triphenyl phosphate, 5038 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health