Phosphoric acid, tributyl ester
RTECS #
TC7700000
CAS #
Updated
March 2019
Molecular Weight
266.36
Molecular Formula
C12H27O4P
Synonyms
Butyl phosphate, tri-
Celluphos 4
MCS 2495
TBP
Tributilfosfato (Italian)
Tributyl phosphate
Tributyl phosphate (ACGIH:OSHA)
Tributyle (phosphate de) (French)
Tributylfosfaat (Dutch)
Tributylfosfat (Czech)
Tributylphosphat (German)
Tri-n-butyl phosphate
Celluphos 4
MCS 2495
TBP
Tributilfosfato (Italian)
Tributyl phosphate
Tributyl phosphate (ACGIH:OSHA)
Tributyle (phosphate de) (French)
Tributylfosfaat (Dutch)
Tributylfosfat (Czech)
Tributylphosphat (German)
Tri-n-butyl phosphate
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 500 mg | severe | AJOPAA 29,1363,1946 |
| eye /rabbit | 100 mg | mild | HPV341 -,-,2001 |
| skin /guinea pig | 10%/24H | mild | HPV341 -,-,2001 |
| skin /human | 75%/3H | HPV341 -,-,2001 | |
| skin /human | 50%/24H | HPV341 -,-,2001 | |
| skin /rabbit | 500 mg | severe | HPV341 -,-,2001 |
| skin /rabbit | 10% | HPV341 -,-,2001 | |
| skin /rabbit | 10 mg/24H open irritation test | JIHTAB 26,269,1944 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| mutation in microorganisms | /Salmonella typhimurium | 500 µg/plate (+/-enzymatic activation step) | GISAAA 51(9),81,1986 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 7500 mg/kg (6-15D pregnant) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | NTIS** OTS0529384 |
| oral/rat | 43770 mg/kg (multigeneration) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | FAATDF 40,90,1997 |
| oral/rat | 4350 mg/kg (6-15D pregnant) | Reproductive: Other effects on female | HPV341 -,-,2001 |
| oral/rat | 1375 mg/kg (7-17D pregnant) | Reproductive: Other effects on female | HPV341 -,-,2001 |
| oral/rat | 5500 mg/kg (7-17D pregnant) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | HPV341 -,-,2001 |
| oral/rabbit | 3250 mg/kg (6-18D pregnant) | Reproductive: Other effects on female | HPV341 -,-,2001 |
| oral/rabbit | 10075 mg/kg (6-18D pregnant) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | HPV341 -,-,2001 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 229 gm/kg/78W- continuous | Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors | TOXID9 36(1 Pt2),174,1997 |
| oral/mouse | lowest published toxic dose: 64800 mg/kg/72W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains | HPV341 -,-,2001 |
| oral/rat | lowest published toxic dose: 263 gm/kg/2Y- continuous | Tumorigenic: Neoplastic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors | TOXID9 36(1 Pt2),174,1997 |
| oral/rat | lowest published toxic dose: 23520 mg/kg/2Y- intermittent | Tumorigenic: Neoplastic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors Tumorigenic: Increased incidence of tumors in susceptible strains | HPV341 -,-,2001 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Hamster, ovary | Inhibitor Concentration (20 percent kill): 22 µmol/L/24H | Endocrine: Other changes | TXCYAC 314,76,2013 |
| In Vitro/jrd | Inhibitor Concentration Low: 1000 µmol/L/24H | In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. | TIVIEQ 33,153,2016 |
| In Vitro/jrd | Inhibitor Concentration (20 percent kill): 183.6 µmol/L/24H | Endocrine: Other changes | TIVIEQ 33,153,2016 |
| inhalation/cat | Lowest published lethal concentration: 24510 mg/m3/5H | Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis | EDWU** -,-,1937 |
| inhalation/cat | Lowest published lethal concentration: 24510 mg/m3/5H | HPV341 -,-,2001 | |
| inhalation/mouse | lethal concentration (50 percent kill): 1300 mg/m3 | GTPZAB 15(8),30,1971 | |
| inhalation/rat | lowest published toxic concentration: 1500 mg/m3/6H | Lung, Thorax, or Respiration: Other changes Skin: After topical application: Primary irritation | HPV341 -,-,2001 |
| inhalation/rat | lethal concentration (50 percent kill): >42000 mg/m3/6H | HPV341 -,-,2001 | |
| inhalation/rat | lethal concentration (50 percent kill): 28000 mg/m3/1H | HPV341 -,-,2001 | |
| intraperitoneal/mouse | lowest published toxic dose: 100 mg/kg | Brain and Coverings: Other degenerative changes | TOLED5 135,89,2002 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 158.5 mg/kg | HPV341 -,-,2001 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 251 mg/kg | GTPZAB 15(8),30,1971 | |
| intraperitoneal/rat | lowest published lethal dose: 800 mg/kg | HPV341 -,-,2001 | |
| intravenous/rat | lowest published lethal dose: 100 mg/kg | Behavioral: General anesthetic Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes | NATUAS 179,154,1957 |
| intravenous/rat | lowest published lethal dose: 100 mg/kg | HPV341 -,-,2001 | |
| oral/chicken | lethal dose (50 percent kill): 1500 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | TIHEEC 6,415,1990 |
| oral/chicken | lethal dose (50 percent kill): 1500 mg/kg | HPV341 -,-,2001 | |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 1189 mg/kg | GISAAA 39(4),86,1974 | |
| oral/mouse | lethal dose (50 percent kill): 900 mg/kg | HPV341 -,-,2001 | |
| oral/rat | lethal dose (50 percent kill): 1390 mg/kg | HPV341 -,-,2001 | |
| skin/guinea pig | lowest published lethal dose: 9700 mg/kg | HPV341 -,-,2001 | |
| skin/rabbit | lethal dose (50 percent kill): >3100 mg/kg | HPV341 -,-,2001 | |
| subcutaneous/mouse | lethal dose (50 percent kill): 764 mg/kg | JKXXAF #72-18000 | |
| subcutaneous/mouse | lowest published lethal dose: 3000 mg/kg | HPV341 -,-,2001 | |
| unreported route/mouse | lethal dose (50 percent kill): 1200 mg/kg | GISAAA 33(7),100,1968 | |
| unreported route/rat | lethal dose (50 percent kill): 1400 mg/kg | GISAAA 33(7),100,1968 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 13600 mg/m3/5H/17W- intermittent | Liver: Liver function tests impaired | GTPZAB 15(8),30,1971 |
| inhalation/rabbit | lowest published toxic concentration: 13.6 mg/kg/16W- continuous | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HPV341 -,,2001 |
| inhalation/rat | lowest published toxic concentration: 500 mg/m3/6H/30D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0535406 |
| inhalation/rat | lowest published toxic concentration: 13.6 mg/m3/16W- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HPV341 -,,2001 |
| inhalation/rat | lowest published toxic concentration: 15 gm/m3/4W- intermittent | Endocrine: Other changes | GISAAA 55(12),56,1990 |
| oral/mouse | lowest published toxic dose: 109 gm/kg/91D- continuous | Kidney, Ureter, and Bladder: Changes in bladder weight Related to Chronic Data: Changes in testicular weight Related to Chronic Data: Changes in uterine weight | JTSCDR 5,270,1980 |
| oral/mouse | lowest published toxic dose: 33600 mg/kg/28D- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0526409 |
| oral/mouse | lowest published toxic dose: 21000 mg/kg/4W- continuous | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV341 -,,2001 |
| oral/mouse | lowest published toxic dose: 84000 mg/kg/4W- continuous | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV341 -,,2001 |
| oral/rabbit | lowest published toxic dose: 7000 mg/kg/7D- continuous | Kidney, Ureter, and Bladder: Proteinuria | HPV341 -,,2001 |
| oral/rabbit | lowest published toxic dose: 5200 mg/kg/13D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV341 -,,2001 |
| oral/rat | lowest published toxic dose: 27 gm/kg/90D- continuous | Kidney, Ureter, and Bladder: Other changes Blood: Change in clotting factors Blood: Changes in erythrocyte (RBC) count | TOXID9 5,97,1985 |
| oral/rat | lowest published toxic dose: 12600 mg/kg/10W- continuous | Kidney, Ureter, and Bladder: Other changes in urine composition Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 40,247,1997 |
| oral/rat | lowest published toxic dose: 18900 mg/kg/9W- continuous | Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOLED5 13,29,1982 |
| oral/rat | lowest published toxic dose: 5880 µL/kg/4D- intermittent | Peripheral Nerve and Sensation: Recording from peripheral motor nerve | DCTODJ 6,363,1983 |
| oral/rat | lowest published toxic dose: 6825 mg/kg/13W- continuous | Kidney, Ureter, and Bladder: Other changes | HPV341 -,,2001 |
| oral/rat | lowest published toxic dose: 34125 mg/kg/13W- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Other changes Blood: Normocytic anemia | HPV341 -,,2001 |
| oral/rat | lowest published toxic dose: 13500 mg/kg/90D- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV341 -,,2001 |
| oral/rat | lowest published toxic dose: 5600 mg/kg/2W- continuous | Liver: Changes in liver weight Endocrine: Changes in spleen weight Blood: Normocytic anemia | HPV341 -,,2001 |
| oral/rat | lowest published toxic dose: 1400 mg/kg/7D- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Renal function tests depressed Kidney, Ureter, and Bladder: Changes in kidney weight | HPV341 -,,2001 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 mg/m3 (inhal, vapor) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | NETEEC 52,248,2015 | |
| TOXICOLOGY REVIEW | RTOPDW 55,43,2009 | |
| TOXICOLOGY REVIEW | RTOPDW 60,120,2011 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 5 mg/m3 | DTLVS* 3,262,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.2 ppm (2.2 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 2.5 mg/m3;KZW 5 mg/m3, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.2 ppm (2.2 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.2 ppm (2.5 mg/m3), carc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.2 ppm (2.5 mg/m3), short term exposure limit 0.4 ppm (5 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.2 ppm (2.5 mg/m3), C3 Carcinogen, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 1 ppm (11 mg/m3), skin, 2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.2 ppm (2.5 mg/m3), NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.2 ppm (2.5 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.2 ppm (2.5 mg/m3);short term exposure limit 0.4 ppm (5 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.2 ppm (2.2 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.2 ppm (2.5 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0,2 ppm (2,18 mg/m3), JUL2005 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.5 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.2 ppm (2.5 mg/m3), KZG-week 0.8 ppm (10 mg/m3), carc 3, skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 5 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 5 mg/m3, JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 5 mg/m3;short term exposure limit 5 mg/m3, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 mg/m3 | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 5 mg/m3 | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 mg/m3 | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 mg/m3 | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIBUTYL PHOSPHATE-air | 10H time-weighted average 0.2 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 73730; Number of Industries 79; Total Number of Facilities 4810; Number of Occupations 75; Total Number of Employees Exposed 109402; Total Number of Female Employees Exposed 19015 | |
| National Occupational Hazard Survey 1974 | Hazard Code 73730; Number of Industries 25; Total Number of Facilities 1209; Number of Occupations 30; Total Number of Employees Exposed 30555 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health