Phenothiazine

RTECS #

SN5075000

CAS #

92-84-2
See: NMAM or OSHA Methods

Updated

September 2018

Molecular Weight

199.28

Molecular Formula

C₁₂H₉NS

Synonyms

AFI-Tiazin
Agrazine
Antiverm
Biverm
Contaverm
Dibenzo-1,4-thiazine
Dibenzothiazine
ENT 38
Feeno
Fenothiazine (Dutch)
Fenotiazina (Italian)
Fenoverm
Fentiazin
Helmetina
Lethelmin
Nemazene
Orimon
Padophene
Penthazine
Phenegic
Phenosan
Phenothiazine (ACGIH)
Phenoverm
Phenovis
Phenoxur
Phenthiazine
Reconox
Souframine
Thiodifenylamine (Dutch)
Thiodiphenylamin (German)
Thiodiphenylamine
Tiodifenilamina (Italian)
Wurm-thional
XL-50

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	1250 mg/kg (1-22D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	AJANA2 110,29,1962

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
intravenous/mouse	lethal dose (50 percent kill): 178 mg/kg		CSLNX* NX#00586
oral/cattle	lethal dose (50 percent kill): 500 mg/kg		85JCAE -,1104,1986
oral/child	lowest published lethal dose: 425 mg/kg/5D	Behavioral: Headache Liver: Jaundice, other or unclassified Blood: Normocytic anemia	LANCAO 242,86,1942
oral/mouse	lethal dose (50 percent kill): 5 gm/kg	Behavioral: Antipsychotic	DNEUD5 7,45,1980
oral/rabbit	lethal dose (50 percent kill): 4 gm/kg		85JCAE -,1104,1986
unreported route/wild bird	lowest published lethal dose: 500 mg/kg		JACSAT 66,888,1944

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 5 mg/m³ (skin)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		PLMJAP 6,160,1975
TOXICOLOGY REVIEW		CLCHAU 19,361,1973
TOXICOLOGY REVIEW		BLREV* 4,226,1990
TOXICOLOGY REVIEW		MEDIAV 37,263,2009
TOXICOLOGY REVIEW		NTAPM* -,689,1995
TOXICOLOGY REVIEW		FCTOD7 109,1,2017

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,198,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 5 mg/m³ (skin)	DTLVS* 3,204,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 5 mg/m³, JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 5 mg/m³, Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 5 mg/m³, skin, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 5 mg/m³, short term exposure limit 10 mg/m³, skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 5 mg/m³, Skin, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 5 mg/m³, skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 5 mg/m³, skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 5 mg/m³;short term exposure limit 10 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 5 mg/m³, skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 5 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 5 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 5 mg/m³, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 5 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 5 mg/m³, Skin, JAN1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENOTHIAZINE-air	10H time-weighted average 5 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 84116; Number of Industries 54; Total Number of Facilities 5473; Number of Occupations 68; Total Number of Employees Exposed 88048; Total Number of Female Employees Exposed 8791
National Occupational Hazard Survey 1974	Hazard Code 84116; Number of Industries 5; Total Number of Facilities 175; Number of Occupations 15; Total Number of Employees Exposed 5639

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health