2,4-Pentanediol, 2-methyl-

RTECS #

SA0810000

CAS #

107-41-5
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

118.20

Molecular Formula

C₆H₁₄O₂

Synonyms

2,4-Dihydroxy-2-methylpentane
2-Methyl pentane-2,4-diol
2-Methyl-2,4-pentanediol
alpha,alpha,alpha'-Trimethyltrimethylene glycol
Diolane
Hexylene glycol
Hexylene glycol (ACGIH)
Isol
Pinakon

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	465 mg open irritation test	mild	UCDS** 11/3/1971
skin /rabbit	465 mg/24H	moderate	JPETAB 82,377,1944
skin /rabbit	500 mg/24H	moderate	FCTXAV 16,777,1978

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/human	lowest published toxic concentration: 50 ppm/15M	Olfaction: Other olfaction effects Eye: Other eye effects Lung, Thorax, or Respiration: Other changes	34ZIAG -,312,1969
inhalation/human	lowest published toxic concentration: 50 ppm	Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes	JIHTAB 28,262,1946
intraperitoneal/mouse	lethal dose (50 percent kill): 1299 mg/kg		SCCUR* -,5,1961
intraperitoneal/rat	lowest published lethal dose: 1500 mg/kg	Behavioral: General anesthetic Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Renal function tests depressed	JPPMAB 11,150,1959
oral/guinea pig	lethal dose (50 percent kill): 2800 mg/kg	Behavioral: General anesthetic Behavioral: Muscle weakness Liver: Other changes	FEPRA7 4,142,1945
oral/mouse	lethal dose (50 percent kill): 3097 mg/kg		JAPMA8 45,669,1956
oral/rabbit	lethal dose (50 percent kill): 3200 mg/kg	Behavioral: General anesthetic Behavioral: Muscle weakness Liver: Other changes	FEPRA7 4,142,1945
oral/rat	lethal dose (50 percent kill): 3700 mg/kg		NPIRI* 1,68,1974
skin/rabbit	lethal dose (50 percent kill): 8560 µL/kg		34ZIAG -,731,1969
subcutaneous/rabbit	lethal dose (50 percent kill): 13 gm/kg	Skin: After systemic exposure: Dermatitis, other	FCTXAV 16,777,1978

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-ceiling concentration 25 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		JACTDZ 4(5),223,1985

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,256,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	ceiling concentration 25 ppm (121 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 10 ppm (49 mg/m³);KZW 10 ppm (49 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 25 ppm (123 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	ceiling concentration 25 ppm (125 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 25 ppm (120 mg/m³), short term exposure limit 40 ppm (200 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VLE 25 ppm (125 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 10 ppm (49 mg/m³), 2011
Occupational Exposure Limit-ICELAND	short term exposure limit 25 ppm (125 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	ceiling concentration 25 ppm (125 mg/m³), 2006
Occupational Exposure Limit-MEXICO	peak 25 ppm (125 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	ceiling concentration 25 ppm (121 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 20 ppm (100 mg/m³), JAN1999
Occupational Exposure Limit-SWEDEN	ceiling concentration 25 ppm (120 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 10 ppm (49 mg/m³), KZG-week 20 ppm (98 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-C 125 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 25 ppm (123 mg/m³);short term exposure limit 25 ppm (123 mg/m³), OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEXYLENE GLYCOL-air	ceiling concentration 25 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 37630; Number of Industries 253; Total Number of Facilities 43088; Number of Occupations 167; Total Number of Employees Exposed 754186; Total Number of Female Employees Exposed 231390
National Occupational Hazard Survey 1974	Hazard Code 37630; Number of Industries 224; Total Number of Facilities 30332; Number of Occupations 149; Total Number of Employees Exposed 373068

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health