2-Pentanone, 4-hydroxy-4-methyl-

RTECS #

SA9100000

CAS #

123-42-2
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

116.18

Molecular Formula

C₆H₁₂O₂

Synonyms

2-Methyl-2-pentanol-4-one
4-Hydroxy-2-keto-4-methylpentane
4-Hydroxy-4-methyl pentan-2-one
4-Hydroxy-4-methyl-2-pentanone
4-Hydroxy-4-methyl-2-pentanone (OSHA)
4-Hydroxy-4-methyl-pentan-2-on (German, Dutch)
4-Hydroxy-4-methylpentanone-2
4-Idrossi-4-metil-pentan-2-one (Italian)
Diacetonalcohol (Dutch)
Diacetonalcool (Italian)
Diacetonalkohol (German)
Diacetone
Diacetone alcohol
Diacetone alcohol (ACGIH:OSHA)
Diacetone-alcool (French)
Diketone alcohol
Pyranton
Tyranton

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /human	100 ppm/15M		JIHTAB 28,262,1946
eye /rabbit	20 mg	severe	AJOPAA 29,1363,1946
eye /rabbit	100 µL/24H	severe	NTIS** OTS0557741
skin /rabbit	10 mg/24H open irritation test		JIHTAB 30,63,1948
skin /rabbit	500 mg open irritation test	mild	UCDS** 6/29/1959

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	lowest published toxic concentration: 100000 mg/m³/20M	Eye: Conjunctiva irritation Behavioral: Somnolence (general depressed activity)	VCVGK* -,445,1994
inhalation/human	lowest published toxic concentration: 475 mg/m³	Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVGK* -,445,1994
inhalation/human	lowest published toxic concentration: 1900 mg/m³	Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,445,1994
inhalation/human	lowest published toxic concentration: 100 ppm	Eye: Other eye effects Behavioral: Headache Gastrointestinal: Nausea or vomiting	NPIRI* 1,21,1974
inhalation/human	lowest published toxic concentration: 400 ppm	Lung, Thorax, or Respiration: Other changes	NPIRI* 1,21,1974
inhalation/mouse	lowest published toxic concentration: 23000 mg/m³	Brain and Coverings: Other degenerative changes	VCVGK* -,445,1994
inhalation/mouse	lowest published toxic concentration: 100000 mg/m³/20M	Eye: Conjunctiva irritation Behavioral: Somnolence (general depressed activity)	VCVGK* -,445,1994
inhalation/rabbit	lowest published toxic concentration: 100000 mg/m³/20M	Eye: Conjunctiva irritation Behavioral: Somnolence (general depressed activity)	VCVGK* -,445,1994
inhalation/rat	lowest published toxic concentration: 100000 mg/m³/20M	Eye: Conjunctiva irritation Behavioral: Somnolence (general depressed activity)	VCVGK* -,445,1994
inhalation/rat	Lowest published lethal concentration: 1000 ppm/4H		NTIS** OTS0557741
intramuscular/rabbit	lowest published lethal dose: 2792 mg/kg	Behavioral: Coma Lung, Thorax, or Respiration: Respiratory depression	JPETAB 33,175,1928
intraperitoneal/mouse	lethal dose (50 percent kill): 933 mg/kg		SCCUR* -,3,1961
intravenous/rabbit	lowest published lethal dose: 2792 mg/kg	Lung, Thorax, or Respiration: Respiratory depression	JPETAB 33,175,1928
intravenous/rat	lowest published lethal dose: 3024 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Coma	JPETAB 33,175,1928
oral/mouse	lethal dose (50 percent kill): 3950 mg/kg		JAPMA8 45,669,1956
oral/mouse	lethal dose (50 percent kill): 3000 mg/kg	Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,445,1994
oral/rabbit	lowest published lethal dose: 4653 mg/kg	Lung, Thorax, or Respiration: Respiratory depression	JPETAB 33,175,1928
oral/rat	lethal dose (50 percent kill): 2520 mg/kg	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Liver: Other changes	NTIS** OTS0557732
oral/rat	lethal dose (50 percent kill): 4000 mg/kg	Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,445,1994
skin/rabbit	lethal dose (50 percent kill): 13500 mg/kg		NPIRI* 1,21,1974

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mammal (species unspecified)	lowest published toxic concentration: 250 mg/m³/244D- intermittent	Brain and Coverings: Changes in surface EEG Cardiac: EKG changes not diagnostic of above	VCVGK* -,445,1994
inhalation/rat	lowest published toxic concentration: 4494 mg/m³/6W- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Pigmented or nucleated red blood cells Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0536235
inhalation/rat	lowest published toxic concentration: 1000 mg/m³/60D- intermittent	Cardiac: Arrythmias (indlucing changes in conduction)	VCVGK* -,445,1994
inhalation/rat	lowest published toxic concentration: 1000 mg/m³/122D- intermittent	Brain and Coverings: Other degenerative changes	VCVGK* -,445,1994
inhalation/rat	lowest published toxic concentration: 1000 mg/m³/244D- intermittent	Cardiac: Cardiomyopathy including infarction Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Other proteins	VCVGK* -,445,1994
oral/rabbit	lowest published toxic dose: 12 mL/kg/12D- intermittent	Behavioral: General anesthetic Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,445,1994
oral/rat	lowest published toxic dose: 1200 mg/kg/30D- continuous	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	NTIS** OTS0557741

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 50 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 50 ppm (240 mg/m³)	DTLVS* 3,70,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 50 ppm (238 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 50 ppm (240 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 50 ppm (241 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 50 ppm (240 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 50 ppm (240 mg/m³), short term exposure limit 75 ppm (360 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 50 ppm (240 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 20 ppm (96 mg/m³), 2011
Occupational Exposure Limit-ICELAND	time-weighted average 50 ppm (240 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 50 ppm (240 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 50 ppm (240 mg/m³);short term exposure limit 75 ppm (360 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 50 ppm (238 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 25 ppm (120 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 50 ppm (238 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 100 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 25 ppm (120 mg/m³);short term exposure limit 50 ppm (240 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 20 ppm (96 mg/m³), KZG-week 40 ppm (192 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 120 mg/m³, 2003
Occupational Exposure Limit-TURKEY	time-weighted average 50 ppm (240 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 50 ppm (241 mg/m³);short term exposure limit 75 ppm (362 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 50 ppm (240 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 50 ppm (240 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 50 ppm (240 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 50 ppm (240 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIACETONE ALCOHOL-air	10H time-weighted average 50 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code M4016; Number of Industries 194; Total Number of Facilities 20857; Number of Occupations 116; Total Number of Employees Exposed 264662; Total Number of Female Employees Exposed 67291
National Occupational Hazard Survey 1974	Hazard Code M4016; Number of Industries 191; Total Number of Facilities 20435; Number of Occupations 95; Total Number of Employees Exposed 167915

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health