Pentaerythritol
RTECS #
RZ2490000
CAS #
Updated
September 2013
Molecular Weight
136.17
Molecular Formula
C5H12O4
Synonyms
1,3-Propanediol, 2,2-bis(hydroxymethyl)-
2,2-Bis(hydroxymethyl)-1,3-propanediol
Auxinutril
Hercules P6
Maxinutril
Methane tetramethylol
Monopentek
PE
Pentaerythrite
Pentaerythritol (ACGIH:OSHA)
Pentek
Tetrahydroxymethylmetane
Tetrakis(hydroxymethyl)methane
Tetramethylolmethane
2,2-Bis(hydroxymethyl)-1,3-propanediol
Auxinutril
Hercules P6
Maxinutril
Methane tetramethylol
Monopentek
PE
Pentaerythrite
Pentaerythritol (ACGIH:OSHA)
Pentek
Tetrahydroxymethylmetane
Tetrakis(hydroxymethyl)methane
Tetramethylolmethane
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | Lethal concentration: >11 gm/m3/6H | TXAPA9 6,351,1964 | |
oral/guinea pig | lethal dose (50 percent kill): 11300 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Tremor Behavioral: Ataxia | TXAPA9 6,351,1964 |
oral/mouse | lethal dose (50 percent kill): 18500 mg/kg | VCVGK* -,158,1984 | |
oral/mouse | lethal dose (50 percent kill): 25500 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Tremor Behavioral: Ataxia | TXAPA9 6,351,1964 |
oral/rabbit | lethal dose (50 percent kill): 18500 mg/kg | Behavioral: General anesthetic Gastrointestinal: Ulceration or bleeding from stomach Liver: Other changes | GISAAA 36(2),25,1971 |
oral/rabbit | lethal dose (50 percent kill): 18500 mg/kg | VCVGK* -,158,1984 | |
oral/rat | lethal dose (50 percent kill): 19500 mg/kg | Behavioral: General anesthetic Gastrointestinal: Ulceration or bleeding from stomach Liver: Other changes | GISAAA 36(2),25,1971 |
oral/rat | lethal dose (50 percent kill): 18500 mg/kg | VCVGK* -,158,1984 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rabbit | lowest published toxic dose: 10605 mg/kg/30W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin) | GISAAA 36(2),25,1971 |
oral/rat | lowest published toxic dose: 10600 µg/kg/30W- intermittent | Behavioral: Alteration of classical conditioning | GISAAA 36(2),25,1971 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 10 mg/m3 | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | FCTOD7 47,1287,2009 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD | NUISANCE PARTICULATES | DTLVS* 3,199,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-BELGIUM | time-weighted average 10 mg/m3, MAR2002 | |
Occupational Exposure Limit-FINLAND | time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 10 mg/m3, FEB2006 | |
Occupational Exposure Limit-KOREA | time-weighted average 10 mg/m3, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 mg/m3, JAN2002 | |
Occupational Exposure Limit-PERU | time-weighted average 10 mg/m3 (inhal), 4 mg/m3 (resp), JUL2005 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 4 mg/m3, JUN2003 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 5 mg/m3 (respirable dust), 2003 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 10 mg/m3 (total dust), 2003 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 10 mg/m3;short term exposure limit 20 mg/m3 (inhal. dust), OCT2007 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 4 mg/m3 (resp. dust), OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1915.1000,1993 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTAERYTHRITOL, resp. fraction-air | 10H time-weighted average 5 mg/m3 | NIOSH* DHHS #92-100,1992 |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTAERYTHRITOL, total dust-air | 10H time-weighted average 10 mg/m3 | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code X6984; Number of Industries 1; Total Number of Facilities 18; Number of Occupations 2; Total Number of Employees Exposed 201 | |
National Occupational Exposure Survey 1983 | Hazard Code 54185; Number of Industries 122; Total Number of Facilities 15717; Number of Occupations 97; Total Number of Employees Exposed 271094; Total Number of Female Employees Exposed 60232 | |
National Occupational Hazard Survey 1974 | Hazard Code 54185; Number of Industries 93; Total Number of Facilities 6400; Number of Occupations 81; Total Number of Employees Exposed 89325 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health