Ozone
RTECS #
RS8225000
CAS #
Updated
March 2019
Molecular Weight
48.00
Molecular Formula
O3
Synonyms
Ozon (Polish)
Ozone (ACGIH:OSHA)
Triatomic oxygen
Ozone (ACGIH:OSHA)
Triatomic oxygen
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 2 ppm/4H | JPCAAC 10,17,1960 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | inhalation/human | 500 ppb/6H | MEHYDY 4,165,1978 |
| Cytogenetic Analysis | leukocyte/human | 7230 ppb/1H | ENVRAL 12,188,1976 |
| Cytogenetic Analysis | other cell types/human | 8 ppm/5M-continuous | NATUAS 194,793,1962 |
| Cytogenetic Analysis | inhalation/rat | 28 mg/m3/5D-continuous | GISAAA 44(9),12,1979 |
| Cytogenetic Analysis | inhalation/hamster | 200 ppb/5H | ENVRAL 4,262,1971 |
| Cytogenetic Analysis | fibroblast/chicken | 1 µg/L/30M | ZEKBAI 67,113,1965 |
| Cytogenetic Analysis | inhalation/hamster | 0.38 µg/L/5H | VCVN5* -,166,1989 |
| Cytogenetic Analysis | inhalation/human | 200 ppb/4H- intermittent | EMMUEG 44,179,2004 |
| DNA adduct | inhalation/guinea pig | 0.4 ppm/2H | INHTE5 9,811,1997 |
| DNA adduct | inhalation/human | 0.4 ppm/2H | INHTE5 9,811,1997 |
| DNA Damage | other cell types/human | 0.9 mmol/L/1H | MUREAV 517,13,2002 |
| DNA Damage | inhalation/mouse | 1 ppm/90M | MUREAV 520,63,2002 |
| DNA Damage | other cell types/cattle | 50 µmol/L/10M | MUREAV 585,60,2005 |
| DNA Damage | /Other microorganisms | 70 pph | JOHYAY 78,199,1977 |
| DNA Damage | fibroblast/mouse | 25 mmol/L | BIJOAK 247,69,1987 |
| DNA Damage | /Escherichia coli | 500 µg/L | AIPAAV 114,595,1968 |
| DNA inhibition | lung/hamster | 2 ppm/1H | JTEHD6 17,119,1986 |
| DNA repair | /Escherichia coli | 50 ppm/30M | BBRCA9 77,220,1977 |
| Dominant Lethal Test | inhalation/other insects | 30 ppm/3H-continuous | ENMUDM 4,657,1982 |
| micronucleus test | inhalation/human | 200 ppb/4H- intermittent | EMMUEG 44,179,2004 |
| micronucleus test | inhalation/human | 200 ppb/4H | MUTAEX 21,131,2006 |
| micronucleus test | inhalation/human | 200 ppb/4H-continuous | MUTAEX 21,131,2006 |
| morphological transform | fibroblast/mouse | 5 ppm | CRNGDP 7,1611,1986 |
| morphological transform | embryo/hamster | 5 ppm | CRNGDP 7,1611,1986 |
| mutation in microorganisms | /Salmonella typhimurium | 19 ppb/35M (+enzymatic activation step) | EMMUEG 17(Suppl 19),22,1991 |
| mutation in microorganisms | /Salmonella typhimurium | 3 mg/L (-enzymatic activation step) | OZSEDS 8,217,1986 |
| mutation in microorganisms | /Escherichia coli | 50 ppm (-enzymatic activation step) | MGGEAE 197,472,1984 |
| phage inhibition capacity | /Escherichia coli | 50 ppm | CNJGA8 26,706,1984 |
| sister chromatid exchange | lung/human | 250 ppb/1H-continuous | ENVRAL 18,336,1979 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 1040 ppb/24H (6-9D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 48,19,1979 |
| inhalation/rat | 1500 ppb/24H (17-20D pregnant) | Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Physical | TOLED5 5,3,1980 |
| inhalation/mammal (species unspecified) | 2 mg/m3 (9-12D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral | VCVN5* -,166,1989 |
| inhalation/mammal (species unspecified) | 2 mg/m3 (17-20D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral | VCVN5* -,166,1989 |
| inhalation/rat | 3 ppm (5D pregnant) | Reproductive: Maternal effects: Uterus, cervix, vagina | REPTED 16,269,2002 |
| inhalation/rat | 3 ppm (10D pregnant) | Reproductive: Maternal effects: Uterus, cervix, vagina | REPTED 16,269,2002 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 5 ppm/2H/75D- intermittent | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors | AEHLAU 20,16,1970 |
| inhalation/mouse | toxic concentration: 608 µg/m3/24W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | JJIND8 75,771,1985 |
| inhalation/mouse | toxic concentration: 1 ppm/6H/2Y- intermittent | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors | NTPTR* NTP-TR-440,1994 |
| inhalation/mouse | lowest published toxic concentration: 44.1 mg/kg/105W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | NTIS** PB95-226999 |
| inhalation/mouse | lowest published toxic concentration: 88.2 mg/kg/105W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | NTIS** PB95-226999 |
| inhalation/mouse | lowest published toxic concentration: 0.5 ppm/12W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Reproductive: Maternal effects: Ovaries, fallopian tubes | VHTODE 43,370,2001 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 100 mg/L/3H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 44,100,2017 |
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 40 mg/L/1H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXAPA9 280,493,2014 |
| inhalation/cat | lethal concentration (50 percent kill): 34500 ppb/3H | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes | IMSUAI 25,301,1956 |
| inhalation/cat | lethal concentration (50 percent kill): 7 mg/m3/3H | VCVN5* -,163,1993 | |
| inhalation/child | lowest published toxic concentration: 135 µg/m3/1H | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Other | TXAPA9 206,185,2005 |
| inhalation/Dog | lowest published toxic concentration: 0.2 mg/m3/1H | Endocrine: Other changes | VCVN5* -,163,1993 |
| inhalation/domestic animal | lowest published toxic concentration: 1 mg/m3/3H | Blood: Methemoglobinemia- Carboxhemoglobinemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | VCVN5* -,163,1993 |
| inhalation/guinea pig | lowest published toxic concentration: 0.2 mg/m3/1H | Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | VCVN5* -,163,1993 |
| inhalation/guinea pig | lethal concentration (50 percent kill): 7 mg/m3/3H | VCVN5* -,163,1993 | |
| inhalation/guinea pig | lowest published toxic concentration: 1 mg/m3/2H | Lung, Thorax, or Respiration: Acute pulmonary edema | VCVN5* -,163,1993 |
| inhalation/guinea pig | lethal concentration (50 percent kill): 24800 ppb/3H | Lung, Thorax, or Respiration: Other changes | IMSUAI 26,63,1957 |
| inhalation/hamster | lethal concentration (50 percent kill): 10500 ppb/4H | AMIHAB 15,181,1957 | |
| inhalation/human | Lowest published lethal concentration: 50 ppm/30M | Behavioral: Headache Vascular: BP lowering not characterized in autonomic section Lung, Thorax, or Respiration: Dyspnea | 34ZIAG -,446,1969 |
| inhalation/human | lowest published toxic concentration: 100 ppm/1M | Lung, Thorax, or Respiration: Other changes Skin: After systemic exposure: Dermatitis, other | NEACA9 19,686,1941 |
| inhalation/human | lowest published toxic concentration: 1 ppm | Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes | AEHLAU 10,295,1965 |
| inhalation/human | lowest published toxic concentration: 200 ppb/4H/4D- intermittent | Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Other changes | AJCMED 161,1855,2000 |
| inhalation/human | lowest published toxic concentration: 600 ppb/2H | Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes | ARDSBL 118,287,1978 |
| inhalation/human | lowest published toxic concentration: 0.2 mg/m3 | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Respiratory depression | VCVN5* -,163,1993 |
| inhalation/human | lowest published toxic concentration: 0.6 mg/m3/3H | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | VCVN5* -,163,1993 |
| inhalation/human | lowest published toxic concentration: 0.0004 mg/m3 | Olfaction: Change in sensation of smell | VCVN5* -,163,1993 |
| inhalation/human | lowest published toxic concentration: 0.4 mg/m3/1H | Behavioral: Alteration of classical conditioning | VCVN5* -,163,1993 |
| inhalation/human | lowest published toxic concentration: 0.4 mg/m3/4H | Eye: Changes in refraction Eye: Visual field changes Eye: Other eye effects | VCVN5* -,163,1993 |
| inhalation/human | lowest published toxic concentration: 0.2 mg/m3/30M | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | VCVN5* -,163,1993 |
| inhalation/human | lowest published toxic concentration: 2 mg/m3/1H | Lung, Thorax, or Respiration: Respiratory depression | VCVN5* -,163,1993 |
| inhalation/human | lowest published toxic concentration: 8 mg/m3 | Lung, Thorax, or Respiration: Acute pulmonary edema | VCVN5* -,163,1993 |
| inhalation/human | lowest published toxic concentration: 20 mg/m3 | Behavioral: Rigidity (includes catalepsy) Behavioral: Headache Cardiac: Pulse rate increased without fall in BP | VCVN5* -,163,1993 |
| inhalation/human | lowest published toxic concentration: 0.06 ppm/2H | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | EVHPAZ 108,533,2000 |
| inhalation/human | lowest published toxic concentration: 0.1 ppm/2H | Lung, Thorax, or Respiration: Other changes Blood: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOLED5 134,219,2002 |
| inhalation/human | lowest published toxic concentration: 200 ppb/4H | Blood: Other changes | MUTAEX 21,131,2006 |
| inhalation/man | lowest published toxic concentration: 1860 ppb/75M | Eye: Lacrimation Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Cough | AEHLAU 10,517,1965 |
| inhalation/man | lowest published toxic concentration: 80 ppb/6.6H | Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Respiratory depression Lung, Thorax, or Respiration: Other changes | AEHLAU 46,145,1991 |
| inhalation/mouse | lethal concentration (50 percent kill): 40 mg/m3/3H | VCVN5* -,163,1993 | |
| inhalation/mouse | lethal concentration (50 percent kill): 7.6 mg/m3/4H | VCVN5* -,163,1993 | |
| inhalation/mouse | lethal concentration (50 percent kill): 4 mg/m3/24H | VCVN5* -,163,1993 | |
| inhalation/mouse | lowest published toxic concentration: 1.6 mg/m3/3H | Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | VCVN5* -,163,1993 |
| inhalation/mouse | lowest published toxic concentration: 2 ppm/3H | Lung, Thorax, or Respiration: Other changes Blood: Change in clotting factors Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | JAPTO* 28,779,2008 |
| inhalation/mouse | lowest published toxic concentration: 0.8 ppm/3H | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 -,124,2009 |
| inhalation/mouse | lowest published toxic concentration: 0.8 ppm/30M | Lung, Thorax, or Respiration: Other changes | TOXID9 -,189,2009 |
| inhalation/mouse | lowest published toxic concentration: 0.3 ppm/48H | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 -,393,2009 |
| inhalation/mouse | lowest published toxic concentration: 0.5 ppm/6H | Liver: Other changes | TOXID9 -,433,2009 |
| inhalation/mouse | lowest published toxic concentration: 0.8 ppm/3H | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 -,438,2009 |
| inhalation/mouse | lowest published toxic concentration: 0.5 ppm/3H | Lung, Thorax, or Respiration: Other changes | JPETAB 312,256,2005 |
| inhalation/mouse | lowest published toxic dose: 1 ppm/8H | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | TXAPA9 213,74,2006 |
| inhalation/mouse | lethal concentration (50 percent kill): 0.03 gm/m3/2H | TPKVAL 9,7,1967 | |
| inhalation/mouse | lethal concentration (50 percent kill): 15.3 ppm/2H | TPKVAL 9,7,1967 | |
| inhalation/mouse | lowest published toxic concentration: 0.8 ppm/8H | Lung, Thorax, or Respiration: Other changes | CRNGDP 24,613,2003 |
| inhalation/mouse | lowest published toxic concentration: 300 ppb/24H | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Other | TOXID9 -,42,2008 |
| inhalation/mouse | lowest published toxic concentration: 0.9 ppm/3H | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Other proteins | TOXID9 12,402,2008 |
| inhalation/mouse | lowest published toxic concentration: 0.8 ppm/8H | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 44,190,2005 |
| inhalation/mouse | lowest published toxic concentration: 0.8 ppm/3H | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Biochemical: Metabolism (intermediary): Other proteins | TOXID9 78,144,2004 |
| inhalation/mouse | lowest published toxic concentration: 0.3 ppm/48H | Lung, Thorax, or Respiration: Other changes Immunological Including Allergic: Increase in cellular immune response Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 44,379,2005 |
| inhalation/mouse | lowest published toxic concentration: 2 ppm/2H | Cardiac: Pulse rate decreased with fall in BP Nutritional and Gross Metabolic: Body temperature decrease | EVHPAZ 109(Suppl 4),539,2001 |
| inhalation/mouse | lowest published toxic concentration: 1 ppm/1H | Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma Lung, Thorax, or Respiration: Sputum Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXCYAC 172,69,2002 |
| inhalation/mouse | lowest published toxic concentration: 0.08 ppm/4H | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | EVHPAZ 108,533,2000 |
| inhalation/mouse | lowest published toxic concentration: 0.08 ppm/8H | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | EVHPAZ 108,533,2000 |
| inhalation/mouse | lowest published toxic concentration: 0.8 ppm/3H | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | TOXID9 72,63,2003 |
| inhalation/mouse | lethal concentration (50 percent kill): 12600 ppb/3H | Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | FEPRA7 16,22,1957 |
| inhalation/mouse | lowest published toxic concentration: 0.1 mg/m3 | Behavioral: Alteration of classical conditioning | VCVN5* -,163,1993 |
| inhalation/mouse | lowest published toxic concentration: 2 ppm/3H | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXAPA9 220,72,2007 |
| inhalation/mouse | lowest published toxic concentration: 0.5 ppm/6H | Behavioral: Alteration of classical conditioning | TIHEEC 25,189,2009 |
| inhalation/rabbit | lethal concentration (50 percent kill): 7.4 mg/m3/3H | VCVN5* -,163,1993 | |
| inhalation/rabbit | lethal concentration (50 percent kill): 36 ppm/3H | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes | IMSUAI 25,301,1956 |
| inhalation/rat | lowest published toxic concentration: 0.65 mg/m3/6H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | VCVN5* -,163,1993 |
| inhalation/rat | lowest published toxic concentration: 6.5 mg/m3/3H | Behavioral: Alteration of classical conditioning Lung, Thorax, or Respiration: Respiratory depression Blood: Normocytic anemia | VCVN5* -,163,1993 |
| inhalation/rat | lowest published toxic concentration: 2 mg/m3/24H | Endocrine: Other changes | VCVN5* -,163,1993 |
| inhalation/rat | lowest published toxic concentration: 2 ppm/4H | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | EXLRDA 14,477,1988 |
| inhalation/rat | lowest published toxic concentration: 0.4 ppm/4H | Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Body temperature decrease Biochemical: Metabolism (intermediary): Lipids including transport | INHTE5 6,267,1994 |
| inhalation/rat | lethal concentration (50 percent kill): 28 mg/m3/2H | VCVN5* -,163,1993 | |
| inhalation/rat | lethal concentration (50 percent kill): 4.5 mg/m3/3H | VCVN5* -,163,1993 | |
| inhalation/rat | lethal concentration (50 percent kill): 1 mg/m3/44H | VCVN5* -,163,1993 | |
| inhalation/rat | lowest published toxic concentration: 1.2 mg/m3/18H | Lung, Thorax, or Respiration: Acute pulmonary edema | VCVN5* -,163,1993 |
| inhalation/rat | lowest published toxic concentration: 0.8 ppm/3H | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Other changes | JTEHD6 46,329,1995 |
| inhalation/rat | lowest published toxic concentration: 0.8 ppm/3H | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | JTEHD6 46,329,1995 |
| inhalation/rat | lethal concentration (50 percent kill): 4800 ppb/4H | Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | AMIHAB 15,181,1957 |
| inhalation/rat | lowest published toxic concentration: 0.5 ppm/6H | Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Body temperature decrease | EVHPAZ 109(Suppl 4),539,2001 |
| inhalation/rat | lowest published toxic concentration: 1 ppm/24H | Brain and Coverings: Changes in surface EEG Behavioral: Sleep | TXCYAC 191,89,2003 |
| inhalation/rat | lowest published toxic concentration: 1600 µg/m3/8H | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | JTEHD6 65,1571,2002 |
| inhalation/rat | lowest published toxic concentration: 2 ppm/4H | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | JTEHD6 65,1453,2002 |
| inhalation/rat | lowest published toxic concentration: 2 ppm/3H | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 44,191,2005 |
| inhalation/rat | lowest published toxic concentration: 0.05 ppm/3H | Brain and Coverings: Other degenerative changes | NRTXDN 29,920,2008 |
| inhalation/rat | lowest published toxic dose: 1 ppm/4H | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXCYAC 225,119,2006 |
| inhalation/rat | lethal concentration (50 percent kill): 4.8 ppm | ENTOX* -,325,2005 | |
| inhalation/rat | Lowest published lethal concentration: 0.005 gm/m3/1H | Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Blood: Hemorrhage | TPKVAL 6,116,1964 |
| inhalation/rat | Lowest published lethal concentration: 0.0005 gm/m3/1H | Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance Gastrointestinal: Other changes Liver: Other changes | TPKVAL 6,116,1964 |
| inhalation/rat | Lowest published lethal concentration: 0.5 mg/m3/1H | VCVN5* -,163,1993 | |
| inhalation/rat | lowest published toxic concentration: 0.6 mg/m3/4H | Lung, Thorax, or Respiration: Other changes | TPKVAL 14,73,1975 |
| inhalation/rat | lowest published toxic concentration: 0.06 mg/kg/1D | Endocrine: Hyperglycemia | TXAPA9 306,47,2016 |
| inhalation/woman | lowest published toxic concentration: 350 ppb/75M | Lung, Thorax, or Respiration: Respiratory depression Lung, Thorax, or Respiration: Other changes | INHTE5 12,151,2000 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/domestic animal | lowest published toxic concentration: 9.5 mg/m3/4H/6W- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | VCVN5* -,165,1989 |
| inhalation/guinea pig | lowest published toxic concentration: 0.6 mg/m3/24H/2W- continuous | Behavioral: Food intake (animal) Lung, Thorax, or Respiration: Changes in lung weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | VCVN5* -,165,1989 |
| inhalation/guinea pig | lowest published toxic concentration: 2 ppm/2D- continuous | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Changes in lung weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTEHD6 3,521,1977 |
| inhalation/guinea pig | lowest published toxic concentration: 800 µg/m3/24H/3D- continuous | Lung, Thorax, or Respiration: Changes in lung weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Metabolism (intermediary): Other proteins | TXAPA9 116,209,1992 |
| inhalation/guinea pig | lowest published toxic concentration: 0.7 mg/m3/24H/90D- continuous | Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Acute pulmonary edema Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,165,1989 |
| inhalation/guinea pig | lowest published toxic concentration: 0.6 mg/m3/24H/2W- continuous | Lung, Thorax, or Respiration: Changes in lung weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | VCVN5* -,166,1989 |
| inhalation/guinea pig | lowest published toxic concentration: 0.4 ppm/5W- intermittent | Olfaction: Other olfaction effects Immunological Including Allergic: Increase in cellular immune response Immunological Including Allergic: Increase in humoral response | TXCYAC 199,73,2004 |
| inhalation/human | lowest published toxic concentration: 0.5 mg/m3/7Y- intermittent | Cardiac: Arrythmias (indlucing changes in conduction) Cardiac: Pulse rate decreased with fall in BP Behavioral: Muscle weakness | VCVN5* -,167,1989 |
| inhalation/human | lowest published toxic concentration: 26.5 ppb/37.4Y- continuous | Behavioral: Change in psychophysiological tests | NRTXDN 30,231,2009 |
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 8 mg/m3/24H/14D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,166,1989 |
| inhalation/monkey | lowest published toxic concentration: 0.5 ppm/5D- intermittent | Olfaction: Other olfaction effects | TOPADD 35,27,2007 |
| inhalation/monkey | lowest published toxic concentration: 0.5 ppm/154D- intermittent | Peripheral Nerve and Sensation: Structural change in nerve or sheath Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Biochemical: Metabolism (intermediary): Other proteins | TXAPA9 194,211,2004 |
| inhalation/monkey | lowest published toxic concentration: 0.7 mg/m3/24H/90D- continuous | Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Acute pulmonary edema Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,165,1989 |
| inhalation/monkey | lowest published toxic concentration: 1500 pph/8H/21D- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | TOLED5 29,207,1985 |
| inhalation/monkey | lowest published toxic concentration: 400 ppb/8H/90D- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Fibrosis (interstitial) | EXLRDA 12,57,1987 |
| inhalation/monkey | lowest published toxic concentration: 1.2 mg/m3/4H/4D- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | VCVN5* -,165,1989 |
| inhalation/monkey | lowest published toxic concentration: 1.2 mg/m3/8H/1Y- intermittent | Blood: Other changes | VCVN5* -,165,1989 |
| inhalation/monkey | lowest published toxic concentration: 0.3 mg/m3/8H/90D- intermittent | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | VCVN5* -,165,1989 |
| inhalation/monkey | lowest published toxic concentration: 0.15 ppm/8H/90D- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | TOLED5 24,125,1985 |
| inhalation/monkey | lowest published toxic concentration: 0.3 ppm/8H/90D- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases Biochemical: Metabolism (intermediary): Lipids including transport | TOLED5 24,125,1985 |
| inhalation/monkey | lowest published toxic concentration: 0.64 ppm/8H/1Y- intermittent | Blood: Other changes | ENVRAL 32,445,1983 |
| inhalation/mouse | lowest published toxic concentration: 0.5 ppm/5D/4W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VHTODE 43,370,2001 |
| inhalation/mouse | lowest published toxic concentration: 0.5 ppm/5D/7W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VHTODE 43,370,2001 |
| inhalation/mouse | lowest published toxic concentration: 0.5 ppm/5D/12W- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Endocrine: Changes in spleen weight | VHTODE 43,370,2001 |
| inhalation/mouse | lowest published toxic concentration: 0.5 ppm/5D/12W- continuous | Related to Chronic Data: Changes in testicular weight | VHTODE 43,370,2001 |
| inhalation/mouse | lowest published toxic concentration: 0.5 ppm/5D/12W- continuous | Cardiac: Changes in heart weight Related to Chronic Data: Changes in ovarian weight | VHTODE 43,370,2001 |
| inhalation/mouse | lowest published toxic concentration: 0.2 mg/m3/5H/100D- intermittent | Lung, Thorax, or Respiration: Other changes Immunological Including Allergic: Decreased immune response | VCVN5* -,165,1989 |
| inhalation/mouse | lowest published toxic concentration: 0.7 mg/m3/8H/1Y- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Blood: Changes in erythrocyte (RBC) count | VCVN5* -,165,1989 |
| inhalation/mouse | lowest published toxic concentration: 2 mg/m3/24H/3D- continuous | Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight | VCVN5* -,164,1989 |
| inhalation/mouse | lowest published toxic concentration: 400 ppb/24H/14D- continuous | Lung, Thorax, or Respiration: Changes in lung weight Endocrine: Changes in thymus weight Immunological Including Allergic: Decrease in humoral immune response | ENVRAL 35,490,1984 |
| inhalation/mouse | lowest published toxic concentration: 1 ppm/24H/4W- continuous | Endocrine: Changes in thymus weight Immunological Including Allergic: Decrease in humoral immune response Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JEPOEC 9,243,1989 |
| inhalation/mouse | lowest published toxic concentration: 608 µg/m3/26W- intermittent | Endocrine: Changes in spleen weight | TOLED5 26,139,1985 |
| inhalation/mouse | lowest published toxic concentration: 300 ppb/3D- continuous | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | EXLRDA 20,579,1994 |
| inhalation/mouse | lowest published toxic concentration: 1 ppm/3H/7D- intermittent | Immunological Including Allergic: Uncharacterized (multiple organ involvement) | FCTOD7 107,47,2017 |
| inhalation/mouse | lowest published toxic concentration: 0.5 ppm/6H/1Y- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Related to Chronic Data: Changes in testicular weight | TIHEEC 25,189,2009 |
| inhalation/mouse | lowest published toxic concentration: 0.5 ppm/6H/1Y- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Related to Chronic Data: Changes in ovarian weight | TIHEEC 25,189,2009 |
| inhalation/mouse | lowest published toxic concentration: 1 ppm/5W- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Fibrosing alveolitis Blood: Other changes | TXCYAC 204,75,2004 |
| inhalation/mouse | lowest published toxic concentration: 0.5 ppm/5D- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 -,434,2009 |
| inhalation/mouse | lowest published toxic concentration: 1 ppm/4W- intermittent | Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 -,434,2009 |
| inhalation/mouse | lowest published toxic concentration: 1 ppm/3D- intermittent | Lung, Thorax, or Respiration: Sputum Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TXAPA9 208,117,2005 |
| inhalation/mouse | lowest published toxic concentration: 0.5 ppm/9D- intermittent | Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOLED5 160,127,2006 |
| inhalation/mouse | lowest published toxic concentration: 1 ppm/3D- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXAPA9 208,117,2005 |
| inhalation/mouse | lowest published toxic concentration: 1 ppm/3D- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXAPA9 215,250,2006 |
| inhalation/mouse | lowest published toxic concentration: 0.5 ppm/10D- intermittent | Biochemical: Metabolism (intermediary): Other | TOLED5 160,127,2006 |
| inhalation/mouse | lowest published toxic concentration: 0.25 ppm/4D- intermittent | Lung, Thorax, or Respiration: Other changes | TXAPA9 222,227,2007 |
| inhalation/mouse | lowest published toxic concentration: 0.25 ppm/4D- intermittent | Biochemical: Metabolism (intermediary): Other | TOLED5 173,73,2007 |
| inhalation/mouse | lowest published toxic concentration: 0.6 ppm/15D- intermittent | Blood: Changes in spleen Immunological Including Allergic: Decreased immune response | JTEHF8 69,1511,2006 |
| inhalation/mouse | lowest published toxic dose: 300 ppb/72H-continuous | Cardiac: Other changes Biochemical: Metabolism (intermediary): Other | TOXID9 -,42,2008 |
| inhalation/mouse | lowest published toxic dose: 300 ppb/72H-continuous | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Other | TOXID9 -,42,2008 |
| inhalation/quail | lowest published toxic concentration: 3 mg/m3/24H/7D- continuous | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | ENVRAL 54,39,1991 |
| inhalation/rabbit | lowest published toxic concentration: 100 ppb/2H/13D- intermittent | Lung, Thorax, or Respiration: Other changes | JTEHD6 21,27,1987 |
| inhalation/rat | lowest published toxic concentration: 2 mg/m3/24H/3D- continuous | Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight | VCVN5* -,164,1989 |
| inhalation/rat | lowest published toxic concentration: 1.96 mg/m3/5H/10D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | VCVN5* -,164,1989 |
| inhalation/rat | lowest published toxic concentration: 1.4 mg/m3/24H/7D- continuous | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Fibrosis (interstitial) Lung, Thorax, or Respiration: Dyspnea | VCVN5* -,165,1989 |
| inhalation/rat | lowest published toxic concentration: 0.4 mg/m3/24H/3D- continuous | Gastrointestinal: Other changes Blood: Normocytic anemia | VCVN5* -,165,1989 |
| inhalation/rat | lowest published toxic concentration: 950 ppb/8H/90D- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Other changes | TXAPA9 106,384,1990 |
| inhalation/rat | lowest published toxic concentration: 1600 µg/m3/24H/7D- continuous | Lung, Thorax, or Respiration: Other changes Lung, Thorax, or Respiration: Changes in lung weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | JTEHD6 24,515,1988 |
| inhalation/rat | lowest published toxic concentration: 800 µg/m3/24H/3D- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Other proteins | TXAPA9 116,209,1992 |
| inhalation/rat | lowest published toxic concentration: 700 ppb/2H/28D- intermittent | Lung, Thorax, or Respiration: Respiratory depression Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTEHD6 17,143,1986 |
| inhalation/rat | lowest published toxic concentration: 200 ppb/24H/12W- continuous | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | ENVRAL 42,425,1987 |
| inhalation/rat | lowest published toxic concentration: 750 ppb/24H/14D- continuous | Lung, Thorax, or Respiration: Other changes Blood: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JEPTDQ 3(5-6),247,1980 |
| inhalation/rat | lowest published toxic concentration: 0.25 mg/m3/24H/13W- continuous | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Fibrosis (interstitial) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVN5* -,165,1989 |
| inhalation/rat | lowest published toxic concentration: 9 mg/m3/6H/13W- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Endocrine: Changes in thyroid weight Related to Chronic Data: Changes in testicular weight | VCVN5* -,165,1989 |
| inhalation/rat | lowest published toxic concentration: 0.5 ppm/23H/5D- continuous | Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Body temperature decrease | EVHPAZ 109(Suppl 4),539,2001 |
| inhalation/rat | lowest published toxic concentration: 0.5 ppm/6H/5D- intermittent | Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Body temperature decrease | EVHPAZ 109(Suppl 4),539,2001 |
| inhalation/rat | lowest published toxic concentration: 0.25 ppm/4H/14D- intermittent | Blood: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | ETOPFR 17,1,2004 |
| inhalation/rat | lowest published toxic concentration: 1 ppm/3D- continuous | Lung, Thorax, or Respiration: Other changes Immunological Including Allergic: Increase in cellular immune response Biochemical: Metabolism (intermediary): Other proteins | TXCYAC 197,37,2004 |
| inhalation/rat | lowest published toxic concentration: 0.5 ppm/16W- intermittent | Lung, Thorax, or Respiration: Other changes Blood: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 -,220,2008 |
| inhalation/rat | lowest published toxic concentration: 3.9 mg/m3/24H/13W- continuous | Reproductive: Paternal effects: Testes, epididymis, sperm duct | VCVN5* -,166,1989 |
| inhalation/rat | lowest published toxic concentration: 2.4 mg/m3/6H/4W- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVN5* -,166,1989 |
| inhalation/rat | lowest published toxic concentration: 0.7 mg/m3/24H/90D- continuous | Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Acute pulmonary edema Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,165,1989 |
| inhalation/rat | lowest published toxic concentration: 0.48 ppm/4H/4W- intermittent | Lung, Thorax, or Respiration: Emphysema Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | NEZAAQ 39,757,1984 |
| inhalation/rat | lowest published toxic concentration: 0.8 ppm/90D- intermittent | Olfaction: Other olfaction effects | TOXID9 44,187,2005 |
| inhalation/rat | lowest published toxic concentration: 0.3 ppm/3D- continuous | Lung, Thorax, or Respiration: Other changes Immunological Including Allergic: Increased immune response | TOXID9 66,193,2002 |
| inhalation/rat | lowest published toxic concentration: 0.1 ppm/1W- intermittent | Lung, Thorax, or Respiration: Other changes Immunological Including Allergic: Increase in cellular immune response | TOXID9 60,30,2001 |
| inhalation/rat | lowest published toxic concentration: 0.5 ppm/90D- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Other | TOXID9 60,125,2001 |
| inhalation/rat | lowest published toxic concentration: 0.25 ppm/15D- intermittent | Brain and Coverings: Other degenerative changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | TOLED5 197,193,2010 |
| inhalation/rat | lowest published toxic concentration: 1 ppm/6H/2D- intermittent | TXAPA9 273,551,2013 | |
| inhalation/rat | lowest published toxic concentration: 1 ppm/5H/39D- intermittent | Lung, Thorax, or Respiration: Other changes Endocrine: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TXAPA9 306,47,2016 |
| intraperitoneal/rat | lowest published toxic dose: 61 µg/kg/10D- intermittent | Blood: Other changes Nutritional and Gross Metabolic: Changes in: Other metals Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | PYTOEY 18,579,2011 |
| oral/rat | lowest published toxic dose: 4 mg/kg/40D- continuous | Immunological Including Allergic: Decreased immune response | VCVN5* -,165,1989 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.05 ppm (heavy work) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.08 ppm (moderate work) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 ppm (light work) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.2 ppm (< 2 hours) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | FEPRA7 35,89,1976 | |
| TOXICOLOGY REVIEW | NTIS** PB228-002 | |
| TOXICOLOGY REVIEW | AEHLAU 16,903,1968 | |
| TOXICOLOGY REVIEW | NTIS** CONF-691001 | |
| TOXICOLOGY REVIEW | MUREAV 558,7,2004 | |
| TOXICOLOGY REVIEW | TOLED5 140-141,195,2003 | |
| TOXICOLOGY REVIEW | TOLED5 140-141,281,2003 | |
| TOXICOLOGY REVIEW | EMMUEG 39,69,2002 | |
| TOXICOLOGY REVIEW | MUREAV 566,209,2004 | |
| TOXICOLOGY REVIEW | ENTOX* -,325,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | JTEHD6 6,521,2003 | |
| TOXICOLOGY REVIEW | MUREAV 659,93,2008 | |
| TOXICOLOGY REVIEW | HUTOX* -,661,1996 | |
| TOXICOLOGY REVIEW | MUREAV 681,93,2009 | |
| TOXICOLOGY REVIEW | MUREAV 674,45,2009 | |
| TOXICOLOGY REVIEW | MUREAV 681,51,2009 | |
| TOXICOLOGY REVIEW | MUREAV 674,62,2009 | |
| TOXICOLOGY REVIEW | MUREAV 674,73,2009 | |
| TOXICOLOGY REVIEW | MUREAV 636,36,2007 | |
| TOXICOLOGY REVIEW | MUREAV 667,132,2009 | |
| TOXICOLOGY REVIEW | MUTAEX 26,231,2011 | |
| TOXICOLOGY REVIEW | REPTED 31,319,2011 | |
| TOXICOLOGY REVIEW | MUTAEX 26,51,2011 | |
| TOXICOLOGY REVIEW | MUREAV 728,88,2011 | |
| TOXICOLOGY REVIEW | MUREAV 717,38,2011 | |
| TOXICOLOGY REVIEW | MUREAV 751,15,2012 | |
| TOXICOLOGY REVIEW | MUTAEX 28,485,2013 | |
| TOXICOLOGY REVIEW | MUREAV 744,8,2012 | |
| TOXICOLOGY REVIEW | MUREAV 759,27,2014 | |
| TOXICOLOGY REVIEW | EMMUEG 48,380,2007 | |
| TOXICOLOGY REVIEW | TOLED5 204,148,2011 | |
| TOXICOLOGY REVIEW | MUREAV 762,133,2014 | |
| TOXICOLOGY REVIEW | MUREAV 762,76,2014 | |
| TOXICOLOGY REVIEW | MUTAEX 30,67,2015 | |
| TOXICOLOGY REVIEW | TXAPA9 275,145,2014 | |
| TOXICOLOGY REVIEW | TXCYAC 313,3,2013 | |
| TOXICOLOGY REVIEW | MUREAV 802,1,2016 | |
| TOXICOLOGY REVIEW | NETEEC 52,25,2015 | |
| TOXICOLOGY REVIEW | MUREAV 770,170,2016 | |
| TOXICOLOGY REVIEW | VETODR ,215,2018 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.1 ppm (0.2 mg/m3) | DTLVS* 3,194,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 0.1 ppm (0.02 mg/m3), JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | ceiling concentration 0.1 ppm (0.2 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.1 ppm (0.2 mg/m3);KZW 0.2 ppm (0.4 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | short term exposure limit 0.1 ppm (0.2 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | ceiling concentration 0.1 ppm (0.2 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.05 ppm (0.1 mg/m3), short term exposure limit 0.2 ppm (0.4 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.1 ppm (0.2 mg/m3), VLE 0.2 ppm (0.4 mg/m3), FEB2006 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 0.2 mg/m3, short term exposure limit 0.2 mg/m3, SEP2000 | |
| Occupational Exposure Limit-ICELAND | short term exposure limit 0.1 ppm (0.2 mg/m3), NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.1 ppm (0.2 mg/m3), MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.1 ppm (0.2 mg/m3), short term exposure limit 0.3 ppm (0.6 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | peak 0.1 ppm (0.2 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | ceiling concentration 0.1 ppm (0.20 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.1 ppm (0.2 mg/m3), JAN1999 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.1 mg/m3, MAC(short term exposure limit) 0.6 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.1 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 0.1 ppm (0.2 mg/m3), ceiling concentration 0.3 ppm (0.6 mg/m3), JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 0.1 ppm (0.2 mg/m3), carc 3, JAN2011 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.1 ppm (0.2 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 0.1 ppm (0.2 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | short term exposure limit 0.2 ppm (0.4 mg/m3), OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.1 ppm (0.2 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.1 ppm (0.2 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.1 ppm (0.2 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.1 ppm (0.2 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO OZONE-air | ceiling concentration 0.1 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 81651; Number of Industries 70; Total Number of Facilities 5347; Number of Occupations 67; Total Number of Employees Exposed 72134; Total Number of Female Employees Exposed 32361 | |
| National Occupational Hazard Survey 1974 | Hazard Code 81651; Number of Industries 54; Total Number of Facilities 6329; Number of Occupations 53; Total Number of Employees Exposed 32552 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health