Oxalic acid
RTECS #
RO2450000
CAS #
Updated
December 2018
Molecular Weight
90.04
Molecular Formula
C2H2O4
Synonyms
Acide oxalique (French)
Acido ossalico (Italian)
Aktisal
Aquisal
Ethanedioic acid
Ethanedionic acid
Kyselina stavelova (Czech)
NCI-C55209
Oxaalzuur (Dutch)
Oxalic acid (ACGIH:OSHA)
Oxalsaeure (German)
Acido ossalico (Italian)
Aktisal
Aquisal
Ethanedioic acid
Ethanedionic acid
Kyselina stavelova (Czech)
NCI-C55209
Oxaalzuur (Dutch)
Oxalic acid (ACGIH:OSHA)
Oxalsaeure (German)
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 250 µg/24H | severe | 85JCAE -,311,1986 |
| eye /rabbit | 100 mg/4S rinse | severe | FCTOD7 20,573,1982 |
| skin /rabbit | 500 mg/24H | mild | 85JCAE -,311,1986 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | 8400 mg/kg (7D male/7D pre-21D pregnant) | Reproductive: Effects on fertility: Other measures of fertility Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | NTIS** PB86-167053 |
| oral/mouse | 9.63 gm/kg (7D male/7D prior to copulation/21D pregnant) | Reproductive: Effects on fertility: Other measures of fertility Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB86167053 |
| oral/mouse | 275 mg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB86167053 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, leukemia cells | Inhibitor Concentration (50 percent kill): 310.33 mg/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 26,1150,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 10 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
| In Vitro/Human, lymphocyte | Inhibitor Concentration (30 percent kill): >200 mg/L/45H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 29,901,2015 |
| In Vitro/Human, lymphocyte | Inhibitor Concentration (50 percent kill): >200 mg/L/45H | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,901,2015 |
| In Vitro/Human, monocyte | Inhibitor Concentration Low: 931 mg/L/2H | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,1233,2013 |
| In Vitro/Non-mammalian species, fibroblast | Inhibitor Concentration (50 percent kill): 14.17 mmol/L/24H | In Vitro Toxicity Studies: Cell counting | TIVIEQ 7,537,1993 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 270 mg/kg | TXCYAC 62,203,1990 | |
| oral/Dog | lowest published lethal dose: 1 gm/kg | HBAMAK 4,1377,1935 | |
| oral/woman | lowest published lethal dose: 600 mg/kg | Gastrointestinal: Changes in structure or function of esophagus Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Other changes | YKYUA6 31,959,1980 |
| subcutaneous/cat | lowest published lethal dose: 112 mg/kg | HBAMAK 4,1377,1935 | |
| subcutaneous/frog | lowest published lethal dose: 757 mg/kg | HBAMAK 4,1377,1935 | |
| unreported route/rat | lethal dose (50 percent kill): 382 mg/kg | HBPTO* 1,824,2001 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | lowest published toxic dose: 225 mg/kg/5D- intermittent | Liver: Other changes Blood: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | ARTODN 76,269,2002 |
| oral/mouse | lowest published toxic dose: 2268 mg/kg/14D- continuous | Behavioral: Fluid intake | NTIS** #PB86167053 |
| oral/mouse | lowest published toxic dose: 40425 mg/kg/21W- continuous | Related to Chronic Data: Changes in prostate weight | NTIS** #PB86167053 |
| oral/rat | lowest published toxic dose: 175 gm/kg/70D- continuous | Endocrine: Changes in thyroid weight Musculoskeletal: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXAPA9 48,409,1979 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1 mg/m3;short term exposure limit 2 mg/m3 | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | FNSCA6 2,67,1973 | |
| TOXICOLOGY REVIEW | AINCM* 7,63,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,320,2005 | |
| TOXICOLOGY REVIEW | EMCNA* 25,375,2007 | |
| TOXICOLOGY REVIEW | HUTOX* -,683,1996 | |
| TOXICOLOGY REVIEW | MUREAV 751,49,2012 | |
| TOXICOLOGY REVIEW | FCTOD7 92,38,2016 | |
| TOXICOLOGY REVIEW | FTRPAE 115,155,2016 | |
| TOXICOLOGY REVIEW | JOETD7 175,198,2015 | |
| TOXICOLOGY REVIEW | FCTOD7 107,502,2017 | |
| TOXICOLOGY REVIEW | FCTOD7 110,165,2017 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | RED Completed | RBREV* -,329,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 1 mg/m3 | DTLVS* 3,193,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 1 mg/m3, JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 1 mg/m3, inhal, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 1 mg/m3, MAY2011 | |
| Occupational Exposure Limit-EC | time-weighted average 1 mg/m3, FEB2006 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 1 mg/m3, FEB2006 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 1 mg/m3, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 1 mg/m3, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 1 mg/m3;short term exposure limit 2 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 1 mg/m3, short term exposure limit 2 ppm, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.01 mg(Ag)/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 1 mg/m3; short term exposure limit 2 mg/m3, JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 1 mg/m3;short term exposure limit 2 mg/m3, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 1 mg/m3, inhal, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 1 mg/m3, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 1 mg/m3;short term exposure limit 2 mg/m3, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 1 mg/m3 | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 1 mg/m3 | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 1 mg/m3 | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 1 mg/m3 | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO OXALIC ACID-air | 10H time-weighted average 1 mg/m3;short term exposure limit 2 mg/m3 | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 52480; Number of Industries 75; Total Number of Facilities 6866; Number of Occupations 84; Total Number of Employees Exposed 142000; Total Number of Female Employees Exposed 58727 | |
| National Occupational Hazard Survey 1974 | Hazard Code 52480; Number of Industries 109; Total Number of Facilities 11395; Number of Occupations 66; Total Number of Employees Exposed 180732 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health